Saccharin preferences in food deprived aging rats are altered as a function of perinatal drug exposure

Martin, Joan C.; Martin, Donald C.; Sigman, Gary; Day-Pfeiffer, Heather

doi:10.1016/0031-9384(83)90247-0

Cited by 6 publications

(2 citation statements)

References 19 publications

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“…Earlier experimental investigations of developmental MA have found few effects, including no impairments of learning or memory (Martin, 1975;Martin et al, 1976Martin et al, , 1979Martin et al, , 1983Sato and Fujiwara, 1986;Weissman and Caldecott-Hazard, 1993). Recently, we reported impairments induced by developmental MA treatment on spatial learning and memory (Vorhees et al, 1994a(Vorhees et al, , 1998(Vorhees et al, , 1999, whereas sequential learning in a multiple-T water maze was spared.…”

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confidence: 79%

Adult Learning Deficits after Neonatal Exposure tod-Methamphetamine: Selective Effects on Spatial Navigation and Memory

et al. 2000

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The effects of neonatal d-methamphetamine (MA) treatment on cued and spatial learning and memory were investigated. MA was administered to neonatal rats on postnatal days 11-20. All groups received four subcutaneous injections per day. Group MA40-4 received 40 mg. kg(-1). d(-1) of MA in four divided doses (10 mg/kg per injection). Group MA40-2 received 40 mg. kg(-1). d(-1) of MA in two divided (20 mg/kg/injection) and saline for the other two injections per day. Controls received saline for four injections per day. As adults, both MA groups showed no differences in swimming ability in a straight swimming channel. The MA40-4 group showed no differences in cued learning, but was impaired in hidden platform learning in the Morris water maze on acquisition. They also showed reduced memory performance on probe trials. Similar trends were seen on reversal learning and reversal probe trials. Reduced platform-size learning trials caused spatial learning impairments to re-emerge in the MA40-4 group. The MA40-2 group showed no differences in straight channel swimming, but was slower at finding the visible platform during cued learning. They were also impaired during acquisition and memory trials in the Morris hidden platform maze. They showed a similar trend on reversal learning and memory trials, but were not different during reduced platform-size learning trials. When the MA40-2 group's performance on hidden platform learning and memory trials was adjusted for cued trial performance, the spatial learning deficits remained. Deficits of spatial learning and memory are a selective effect of neonatal methamphetamine treatment irrespective of other learning and performance variables.

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confidence: 79%

Adult Learning Deficits after Neonatal Exposure tod-Methamphetamine: Selective Effects on Spatial Navigation and Memory

et al. 2000

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“…Studies in which treatments were given to the dam during gestation involved s.c. administration of amphetamine or methamphetamine on GD 12–15 (Clark et al, 1970; Adams et al, 1982; Buelke‐Sam et al, 1985; Holson et al, 1985; Vorhees, 1985), GD 7–12 (Acuff‐Smith et al, 1992, 1996), GD 13–18 (Acuff‐Smith et al, 1996), or during all or most of the gestation period (Nasello et al, 1974; Martin, 1975; Hitzemann et al, 1976; Nasello and Ramirez, 1978; Satinder and Sterling, 1983; Sato and Fujiwara, 1986; Cho et al, 1991; Tan, 2003). In one study (Martin et al, 1983), the treatment period during gestation was not specified, and the study is included only for completeness. The treatments in many of the studies resulted in significant decreases in maternal weight gain, associated with a decrease in maternal feed intake.…”

Section: 0 Developmental Toxicity Datamentioning

confidence: 99%