Prenatal methamphetamine-induced anophthalmia in rats

Vorhees, Charles V.; Acuff‐Smith, Karen D.

doi:10.1016/0892-0362(90)90062-h

Cited by 13 publications

(4 citation statements)

References 9 publications

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“…This is in agreement with the work of Cho et al (1991) and Martin (1975) showing delayed eyes opening as well. There are several other studies showing eye defects after prenatal MA exposure (Acuff‐Smith et al, 1996; Vorhees and Acuff‐Smith, 1990). Specifically, prenatal exposure to MA at 20 mg/kg was shown to induce eye defects (i.e., anophthalmia, microphthalmia and folded retina) in 16.7% of the progeny (Acuff‐Smith et al, 1996).…”

Section: Discussionmentioning

confidence: 94%

Cross‐fostering effect on postnatal development of rat pups exposed to methamphetamine during gestation and preweaning periods

Pometlová

Hrubá

Šlamberová

et al. 2008

Intl J of Devlp Neuroscience

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There are studies showing that drug abuse during pregnancy may have a long-term effect on progeny of drug-abusing mothers. Our previous work demonstrated that prenatal and/or postnatal methamphetamine injections impair maternal behavior. The purpose of the present study was to assess the effect of prenatal methamphetamine or stress exposure and postnatal breeding on postnatal development of rat pups. Female rats were injected with methamphetamine (5 mg/kg daily) or physiological saline prior, during and after gestation. Absolute controls did not receive any injections. On postnatal day 1, pups were cross-fostered so that each mother received some of her own and some of the pups from the mothers with the other two treatments. Pups were weighted daily for the entire lactation period. Postural motor reaction development was examined daily by righting reflex between postnatal day 1 and 12. On postnatal day 15 homing test examining pups' nest-seeking behavior was performed. On postnatal day 23 rotarod and bar-holding tests were used to investigate sensorimotor coordination of pups. We demonstrated that prenatal methamphetamine exposure impairs performance of sensorimotor tests (righting reflex on surface and rotarod test). Moreover, the effect of methamphetamine as well as the effect of prenatal stress induced by saline injections was affected by postnatal breeding conditions in sensorimotor tests as well as in the test of homing. Our results support the hypothesis that the variation in rat maternal care could serve as a mechanism for a nongenomic behavioral mode of transmission of traits.

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Section: Discussionmentioning

confidence: 94%

Cross‐fostering effect on postnatal development of rat pups exposed to methamphetamine during gestation and preweaning periods

Pometlová

Hrubá

Šlamberová

et al. 2008

Intl J of Devlp Neuroscience

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“…Similarly, Henderson and McMillen (1990) showed that in cocaine-exposed group there are no changes in the time of eyes opening. There are many other studies showing eye defects (i.e., anophthalmia, microphthalmia and folded retina) after prenatal M exposure (Acuff-Smith, George, Lorens, & Vorhees, 1992;Vorhees & Acuff-Smith, 1990). The type of defect was shown to be dependent on the developmental stage at the time of dosing (Acuff- Smith et al, 1996).…”

Section: Discussionmentioning

confidence: 98%

Effect of methamphetamine exposure and cross‐fostering on sensorimotor development of male and female rat pups

Hrubá

Schutová

Šlamberová

et al. 2008

Developmental Psychobiology

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The present study tested the hypothesis that cross-fostering influences the development of rat pups. Mothers were exposed daily to injection of methamphetamine (M) (5 mg/kg) or saline for 9 weeks: 3 weeks prior to impregnation, throughout gestation and lactation periods. Control females animals without any injections were used. On postnatal day (PD) 1, pups were cross-fostered so that each mother received four pups of her own and eight pups from the mothers with the other two treatments. Offspring were tested for sensorimotor development in preweaning period by using tests of: negative geotaxis, tail pull, righting reflexes, rotarod and bar-holding. Further, the pups were weighed daily. Our results showed that birth weight in prenatally M-exposed pups was lower than in control or saline-exposed pups. Prenatally M-exposed pups gained less weight than control or saline-exposed pups regardless of postnatal treatment and sex. Further, our data demonstrated that prenatal and postnatal M exposure impairs sensorimotor functions in most of the tests. On the other hand, the negative effect of prenatal M exposure was partially suppressed in prenatally M-exposed pups by cross-fostering to control dams. Our hypothesis that cross-fostering may affect postnatal development of pups was confirmed.

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“…Vorhees and Acuff‐Smith ( 1990 ) reported in a Letter to the Editor that preliminary experiments identified anophthalmia associated with prenatal methamphetamine exposure on GD 7–12 at a maternal dose of 50 mg/kg bw s.c. twice/day. Among the three litters treated on these days, 45.5–88.9% of pups had eye abnormalities (almost all anophthalmia).…”

Section: 0 Developmental Toxicity Datamentioning

confidence: 99%

NTP‐CERHR Expert Panel Report on the reproductive and developmental toxicity of amphetamine and methamphetamine

Golub

Costa

Crofton

et al. 2005

Birth Defects Research Pt B

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Prenatal methamphetamine-induced anophthalmia in rats

Cited by 13 publications

References 9 publications

Cross‐fostering effect on postnatal development of rat pups exposed to methamphetamine during gestation and preweaning periods

Cross‐fostering effect on postnatal development of rat pups exposed to methamphetamine during gestation and preweaning periods

Effect of methamphetamine exposure and cross‐fostering on sensorimotor development of male and female rat pups

NTP‐CERHR Expert Panel Report on the reproductive and developmental toxicity of amphetamine and methamphetamine

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