Saccharin effects on morphine-induced temperature change in rats

Bowers, Robin L.; Nicastle, Lionel D.; Falb, Donald C.

doi:10.1016/0091-3057(93)90384-6

Cited by 6 publications

(5 citation statements)

References 15 publications

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“…During pregnancy, the animal was slower to recover from the hypothermia, but on the day after parturition, recovery occurred faster than in controls (171), providing additional evidence for opiate interactions with other systems. Saccharin enhanced the hypothermic effect of morphine and attenuated its hyperthermic phase, supporting the view that sweet substances influence the endogenous opiate system (60).…”

Section: Respiration and Thermoregulationsupporting

confidence: 64%

“…Chronic naloxone not only affected body weight, but also inhibited the stimulation of corticosterone by U50,488, suggesting an interaction between the hormone and the K receptors might be responsible for the weight loss (14). Hypothermia induced by morphine was enhanced by saccharin, supporting the view that sweet substance activate the endogenous opiate system (60). In individuals reporting a greater than normal number of illness, there were also reports of more limitation of foods that mobilize the opiate system (sweets, fats, and bread), as well as more illness from opiate drugs and alcohol, indicating a correlation between the opiate system and these illnesses (45).…”

Section: Olson Olson and Kastinmentioning

confidence: 69%

“…Regulation of body temperature by the opiate system has also been studied, and much of the work from 1993 indicated that the opiate agonists reduce temperature. Both u and K receptors seem to be involved, because morphine (60,171) and U50,488 (50,51,54,73,508,509) lowered it. DADLE, however, had no effect (517), leading to rejection of the idea of involvement of the 6 receptors in this response.…”

Section: Respiration and Thermoregulationmentioning

confidence: 99%

“…DADLE, however, had no effect (517), leading to rejection of the idea of involvement of the 6 receptors in this response. Morphine was reported to have a biphasic effect, first decreasing, then increasing temperature (60). This may account for the conflicting fndings of hyperthermia after morphine (50,52,314), because the measures might have occurred during the second phase.…”

Section: Respiration and Thermoregulationmentioning

confidence: 99%

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Endogenous opiates: 1993

Olson

Kastin

1994

Peptides

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This paper is the sixteenth installment of our annual review of research concerning the opiate system. It is restricted to papers published during 1993 that concern the behavioral effects of the endogenous opiate peptides, and does not include papers dealing only with their analgesic properties. The specific topics this year include stress; tolerance and dependence; eating; drinking; gastrointestinal, renal, and hepatic function; mental illness and mood; learning, memory, and reward; cardiovascular responses; respiration and thermoregulation; seizures and other neurological disorders; electrical-related activity; general activity and locomotion; development; immunological responses; and other behaviors.

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Section: Respiration and Thermoregulationsupporting

confidence: 64%

Section: Olson Olson and Kastinmentioning

confidence: 69%

Section: Respiration and Thermoregulationmentioning

confidence: 99%

Section: Respiration and Thermoregulationmentioning

confidence: 99%

See 2 more Smart Citations

Endogenous opiates: 1993

Olson

Kastin

1994

Peptides

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“…Because saccharin exposure could interact with the unconditioned effects of morphine (e.g., Bergmann, Cohen, & Lieblich, 1984;Bowers, Nicastle, & Falb, 1993), we assessed whether activity in the white boxes interacted with the fluid type (water or saccharin) that was available on a given trial. Fluid type did not interact with drug or trial, Fs < 1.24; the Fluid × Drug × Trial interaction also was not significant, F < 1.…”

Section: Methodsmentioning

confidence: 99%

Morphine-conditioned changes in locomotor activity: Role of the conditioned stimulus.

Bevins¹,

Bardo²

1998

Experimental and Clinical Psychopharmacology

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When a multisensory environment was reliably paired with morphine (2 mg/kg) in rats, that environment, in a drug-free test, evoked a hyperactive conditioned response (CR). When an olfactory cue (banana odor) was the only stimulus element reliably paired with morphine, it also elicited a hyperactive CR. However, a gustatory cue (saccharin solution) evoked a hypoactive CR. This taste-elicited decrease in activity was dose dependent; morphine at 2 and 4 mg/kg conditioned hypoactivity, whereas a higher dose (8 mg/kg) did not. A robust conditioned saccharin aversion occurred only at the highest dose of morphine, suggesting disassociation between the hypoactive CR and taste aversion. A taste cue present during context conditioning also prevented either acquisition or expression of the hyperactive CR to the context. The modality of the conditioned stimulus is a critical determinant of the form of the CR in a morphine locomotor conditioning paradigm. 131This research was supported by U.S. Public Health Service Grants DA05312, DA07746, and DA05623.We are grateful to P. Kraemer, P. Robinet, and J. Valone for their comments on an earlier version of this article. We also thank K. Shanmugham for conducting pilot work and M. Marion for help in conducting some of the experiments reported here.

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