Sa1358 – Epidemiology, Environmental and Metabolic Risk Factors of Pancreatic Adenocarcinoma: A Retrospective Cohort Study

Capasso, Mario; Franceschi, Marilisa; Baldassarre, Gianluca; Rodríguez–Castro, Kryssia Isabel; Antico, Antonio; Crafa, Pellegrino; Nouvenne, Antonio; Franzoni, L.; Barchi, Alberto; Cavatorta, O.; Miraglia, C.; Cavestro, Giulia Martina; Mario, F. Di

doi:10.1016/s0016-5085(19)37645-0

Cited by 17 publications

(26 citation statements)

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“…18 In addition, patients with pancreatic cancer have a poor response to chemotherapy, 19,20 and the 5-year survival rate of pancreatic cancer has only increased from 3% in 1970 to 5% at present. 21 Therefore, more research efforts should be made in the early diagnosis and treatment of pancreatic cancer, and improving early diagnosis rate and the survival rate of pancreatic cancer.…”

Section: Discussionmentioning

confidence: 99%

Epidemiological Characteristics of Pancreatic Cancer in China From 1990 to 2019

Zhu

Guo

et al. 2021

Cancer Control

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Background Pancreatic cancer is an aggressive cancer and is predicted to become the second leading cause of cancer-related deaths in China. To understand the epidemic trend of pancreatic cancer and formulate targeted preventive measures, it is important to analyze the incidence and mortality of pancreatic cancer. Methods The incidence and mortality data of pancreatic cancer in China were obtained from Global Burden of Disease (GBD) data. We used joinpoint regression analysis to calculate the magnitude and direction of trends, and the age-period-cohort method to analyze the effects of chronological age, time period, and birth cohort. Results The age-standardized rates (ASRs) for both incidence and mortality of pancreatic cancer increased from 1990 to 2019, and were higher in males than females. The incidence and mortality rates have increased year by year in the age group above 25 years. The most common age group was 55–79 years, accounting for approximately 50% of all incident cases. In terms of incidence and mortality rates, the overall net drifts were above 0. The local drifts in all age groups were above 0 in both sexes and males, while the local drifts in the 15–39 age groups were below 0 in females. The longitudinal age curves increased with age, with higher incidence and mortality rates, mainly in older age groups. The period rate ratios increased by year. The cohort rate ratios showed an upward trend before 1970 and fluctuated after 1975. Conclusions The burden of pancreatic cancer is still very high in China, and attention should be paid to the key population that is, males and older people. The results of our study can be used by policy makers to allocate resources efficiently to improve early diagnosis and treatment, improving the awareness of self-protection, and advocating a healthy lifestyle to prevent pancreatic cancer.

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Section: Discussionmentioning

confidence: 99%

Epidemiological Characteristics of Pancreatic Cancer in China From 1990 to 2019

Zhu

Guo

et al. 2021

Cancer Control

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“…Risk factors are not easy to identify. There are hereditary risk factors (10%), such as genetic pattern, and environmental (modifiable) factors such as smoking, alcohol consumption, chronic pancreatitis, obesity and diabetes mellitus [ 6 ]. The risk of developing pancreatic cancer increases with age: about 80% patients are at least 60 years old and 71 years is the average age at diagnosis [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

Paraneoplastic Aquagenic Pruritus: A Case of Pancreatic Cancer

Negrão¹,

Machado²,

Mourato³

et al. 2023

Cureus

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Paraneoplastic pruritus has been reported mostly in association with haematological malignancies, and rarely with solid tumours. Aquagenic pruritus is itching without any skin lesion that develops a few minutes after contact with water of any temperature and it is associated with polycythaemia vera or other lymphoproliferative diseases.Here we report a case of a previously healthy 78-year-old Portuguese woman, who had been treated unsuccessfully for aquagenic pruritus for the previous eight months, and presented to the emergency department complaining of pain and swelling in her left leg. Deep vein thrombosis was diagnosed and oral anticoagulation was initiated. Blood tests revealed a normal blood count and normal liver enzymes, except for alkaline phosphatase and lactate dehydrogenase levels, which were slightly elevated. Hypercobalaminaemia and folic acid deficiency were also noted. JAK2 V617F/12 exon mutation was not present. Thoracic, abdominal and pelvic computed tomography revealed a locally advanced pancreatic tumour. Ultrasound-guided fine-needle aspiration cytology of the lesion revealed a moderately differentiated adenocarcinoma of pancreatic ductal origin. Tumour marker assays showed elevation of both carcinoembryonic antigen (CEA) and carbohydrate antigen . Aquagenic pruritus should be thoroughly investigated to exclude a neoplastic disease, especially if treatment is refractory or if another paraneoplastic syndrome is present. Although aquagenic pruritus is more commonly associated with haematological malignancies than solid tumours, a rare case of aquagenic pruritus is described here as a paraneoplastic syndrome of pancreatic cancer. To the best of our knowledge, this is the first case of pancreatic cancer that presented with aquagenic pruritus and dual paraneoplastic syndromes.

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“…Due to the absence of early symptoms and effective methods of detection and treatment, the incidence rate of pancreatic cancer is practically comparable to that of mortality (Sung et al, 2021 ). Furthermore, there is insufficient evidence concerning risk factors for the development of pancreatic cancer and those that are recognized do not adequately explain the development of this malignancy; currently, risk factors are only identified in approximately 40% of cases (Capasso et al, 2018 ). Among them, the predominant environmental risk factors for pancreatic cancer are smoking, alcohol consumption, chronic pancreatitis, age, obesity, and diabetes.…”

Section: Introductionmentioning

confidence: 99%

Construction of a pancreatic cancer prediction model for oxidative stress-related lncRNA

Huang

Wei

Yao

et al. 2023

Funct Integr Genomics

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Long non-coding RNAs (lncRNAs) may play a role in oxidative stress by altering the tumor microenvironment, thereby affecting pancreatic cancer progression. There is currently limited information on oxidative stress-related lncRNAs as novel prognostic markers of pancreatic cancer. Gene expression and clinical data of patients with pancreatic cancer were downloaded from The Cancer Genome Atlas (TCGA-PAAD) and the International Cancer Genome Consortium (ICGC-PACA) database. A weighted gene co-expression network analysis (WGCNA) was constructed to identify genes that were differentially expressed between normal and tumor samples. Based on the TCGA-PAAD cohort, a prediction model was established using lasso regression and Cox regression. The TCGA-PAAD and ICGC-PACA cohorts were used for internal and external validation, respectively. Furthermore, a nomogram based on clinical characteristics was used to predict mortality of patients. Differences in mutational status and tumor-infiltrating immune cells between risk subgroups were also explored and model-based lncRNAs were analyzed for potential immune-related therapeutic drugs. A prediction model for 6-lncRNA was established using lasso regression and Cox regression. Kaplan–Meier survival curves and receiver operating characteristic (ROC) curves indicated that patients with lower risk scores had a better prognosis. Combined with Cox regression analysis of clinical features, risk score was an independent factor predicting overall survival of patients with pancreatic cancer in both the TCGA-PAAD and ICGC-PACA cohorts. Mutation status and immune-related analysis indicated that the high-risk group had a significantly higher gene mutation rate and a higher possibility of immune escape, respectively. Furthermore, the model genes showed a strong correlation with immune-related therapeutic drugs. A pancreatic cancer prediction model based on oxidative stress-related lncRNA was established, which may be used as a biomarker related to the prognosis of pancreatic cancer to evaluate the prognosis of pancreatic cancer patients.

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Sa1358 – Epidemiology, Environmental and Metabolic Risk Factors of Pancreatic Adenocarcinoma: A Retrospective Cohort Study

Cited by 17 publications

References 0 publications

Epidemiological Characteristics of Pancreatic Cancer in China From 1990 to 2019

Epidemiological Characteristics of Pancreatic Cancer in China From 1990 to 2019

Paraneoplastic Aquagenic Pruritus: A Case of Pancreatic Cancer

Construction of a pancreatic cancer prediction model for oxidative stress-related lncRNA

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