S3344 Association Between Hyperuricemia, Gout and Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis

Lee, Gin Yi; Hsieh, Tien‐Chan; Yong, Wai Chung

doi:10.14309/01.ajg.0000786908.24914.b8

Cited by 1 publication

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“…Additionally, several studies have found higher levels of serum uric acid in IBD patients in comparison with the general population. For instance, a recent meta‐analysis concurred with the observed higher levels of uric acid in IBD 23‐25 …”

Section: Discussionmentioning

confidence: 71%

“…For instance, a recent meta-analysis concurred with the observed higher levels of uric acid in IBD. [23][24][25] As noted previously, the etiology of hyperuricemia in IBD has been the subject of extensive research. Another possible explanation is derived from multiple studies showing that low levels of the aromatic amino acid tryptophan (TRP) is associated with a number of immune-mediated diseases including IBD.…”

Section: Discussionmentioning

confidence: 93%

“…For instance, a recent meta‐analysis concurred with the observed higher levels of uric acid in IBD. 23 , 24 , 25 …”

Section: Discussionmentioning

confidence: 99%

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Increased prevalence of gout in patients with inflammatory bowel disease: A population‐based study

Hamid,

Alsabbagh Alchirazi,

Eltelbany

et al. 2023

JGH Open

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Background and AimArthritis is a recognized extra‐intestinal manifestation of inflammatory bowel disease (IBD). Studies show altered uric acid metabolism in IBD. This study aims to investigate the association between IBD and gout.MethodsWe used a multi‐center database (Explorys Inc.) consisting of data from several US healthcare systems. We identified adults diagnosed with Crohn's disease (CD) and ulcerative colitis (UC) between 1999 and 2022. In this cohort, we identified patients diagnosed with gout. We collected demographic data and identified patients diagnosed with IBD‐associated arthritis and those who had intestinal resection. Risk factors associated with gout were collected. Multivariate analysis was used.ResultsOut of the 69 260 780 patients in the database, we identified 209 020 patients with UC (0.30%) of whom 9130 had gout (4.3%). Additionally, 249 480 had CD (0.36%) of whom 14 000 had gout (5.61%). Males were more prevalent in the UC and gout group than in the CD and gout group (58% vs 51%). After adjustment, CD was significantly associated with gout (odds ratio [OR] 1.68, confidence interval [CI]: 1.60–1.75). UC was also significantly associated with gout (OR 1.38, CI: 1.31–1.44). In subgroup analysis with intestinal resection, CD patients who had intestinal resection had higher association with gout versus those without surgery (OR 2.34, CI: 2.25–2.43). Similar increase was observed in the UC group with intestinal resection (OR 1.53, CI: 1.49–1.56).ConclusionIBD is strongly associated with gout, with higher correlation observed with CD. Intestinal resection is associated with an increase in the risk of gout. Patients with IBD who present with new‐onset arthritis should be investigated for gout.

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Section: Discussionmentioning

confidence: 71%

Section: Discussionmentioning

confidence: 93%