Increased prevalence of gout in patients with inflammatory bowel disease: A population‐based study

Abstract

Background and AimArthritis is a recognized extra‐intestinal manifestation of inflammatory bowel disease (IBD). Studies show altered uric acid metabolism in IBD. This study aims to investigate the association between IBD and gout.MethodsWe used a multi‐center database (Explorys Inc.) consisting of data from several US healthcare systems. We identified adults diagnosed with Crohn's disease (CD) and ulcerative colitis (UC) between 1999 and 2022. In this cohort, we identified patients diagnosed with gout. We collected demographic data and identified patients diagnosed with IBD‐associated arthritis and those who had intestinal resection. Risk factors associated with gout were collected. Multivariate analysis was used.ResultsOut of the 69 260 780 patients in the database, we identified 209 020 patients with UC (0.30%) of whom 9130 had gout (4.3%). Additionally, 249 480 had CD (0.36%) of whom 14 000 had gout (5.61%). Males were more prevalent in the UC and gout group than in the CD and gout group (58% vs 51%). After adjustment, CD was significantly associated with gout (odds ratio [OR] 1.68, confidence interval [CI]: 1.60–1.75). UC was also significantly associated with gout (OR 1.38, CI: 1.31–1.44). In subgroup analysis with intestinal resection, CD patients who had intestinal resection had higher association with gout versus those without surgery (OR 2.34, CI: 2.25–2.43). Similar increase was observed in the UC group with intestinal resection (OR 1.53, CI: 1.49–1.56).ConclusionIBD is strongly associated with gout, with higher correlation observed with CD. Intestinal resection is associated with an increase in the risk of gout. Patients with IBD who present with new‐onset arthritis should be investigated for gout.

The effect of colchicine on cancer risk in patients with immune-mediated inflammatory diseases: a time-dependent study based on the Taiwan’s National Health Insurance Research Database

“…Additional file 4 : Table S3 displays the lower aHR of colorectal cancer for the colchicine users among the chronic colitis-(ulcerative colitis, Crohn’s disease) in young adult [ 9 , 18 , 33 ].…”

“…Recently, Hamid et al report that out of the 69,260,780 patients in the database, they identified 209, 020 patients with ulcerative colitis (0.30%) of whom 9130 had gout (4.3%). Additionally, 249,480 had Crohn’s disease (0.36%) of whom 14,000 had gout (5.61%) [ 33 ], such that, the number of the gout with IMIDs-chronic colitis is 9130 + 14,000 = 23,130. We assumed the 75% gout patients with colchicine use, the number of colchicine user is about (23,130) × 0.75 = 17,348.…”