S2068 Histopathological Study of Chronic Hepatitis B: A Comparative Study of Ishak and Metavir Scoring Systems

Mohamadnejad, Mehdi; Tavangar, Seyed Mohamad; Kosari, Farid; Khosravi, Mohamad; Montazeri, Ghodratollah; Estakhri, Arezoo; Mir-Nasseri, Mohammad Mahdi; Fazlollahi, Atoosa; Agah, Shahram; Malekzadeh, Reza

doi:10.1016/s0016-5085(08)61438-9

Cited by 10 publications

(14 citation statements)

References 8 publications

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“…All sections were observed by light microscopy (magnification, ×200), and scoring was performed separately by two independent pathologists. The METAVIR scoring system was used for liver fibrosis scoring ( 29 ). F0=no fibrosis, F1=portal fibrosis without septa, F2=portal fibrosis with few septa, F3=numerous septa without cirrhosis, F4=cirrhosis.…”

Section: Methodsmentioning

confidence: 99%

Peritumoral overexpression of ZBP‑89 is associated with unfavorable disease‑free survival rates in patients with hepatocellular carcinoma following hepatectomy

et al. 2018

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Previous studies have revealed that the peritumoral environment has a profound influence on tumor initiation and progression. Zinc-binding protein-89 (ZBP-89) has been observed to be involved with tumor development, recurrence, and metastasis. High intratumoral expression of ZBP-89 has been associated with improved prognosis in several tumor types. However, the prognostic values of peritumoral expression of ZBP-89 remain to be elucidated in patients with hepatocellular carcinoma (HCC) following curative resection. In the present study, peritumoral ZBP-89 expression was examined using immunohistochemistry in 102 HCC patients who had received curative hepatectomy. Expression of ZBP-89 protein was positive in 66.3% of the peritumoral samples from 102 HCC patients. HCC patients with high peritumoral ZBP-89 expression exhibited significantly shorter disease-free survival (DFS) times (P=0.012) than those patients with low peritumoral ZBP-89 expression. Additionally, high ZBP-89 expression in peritumoral HCC tissue was positively associated with the presence of liver cirrhosis. Univariate and multivariate Cox proportional hazard regression analyses demonstrated that albumin levels ≤35 g/l, multiple tumors, tumor sizes ≥5 cm, and macroscopic vascular invasion may serve as independent prognostic factors for overall survival (OS) [hazard ratio (HR)=2.031; P=0.014] in patients with HCC. The multivariate Cox regression model identified that high ZBP-89 expression, multiple tumors and macroscopic vascular invasion were independent prognostic factors for shorter DFS durations. High expression of ZBP-89 in peritumoral HCC tissues was associated with a shorter DFS in HCC patients following curative hepatectomy. Additionally, high ZBP-89 expression in peritumoral HCC tissue was positively associated with the presence of liver cirrhosis in HCC patients, indicating that cirrhosis accompanied by high ZBP-89 expression may be a contributing factor to the poor prognosis of patients with HCC. Therefore, peritumoral ZBP-89 expression may be a good prognostic marker to predict DFS time in HCC patients following curative hepatectomy and may provide novel insights into the molecular mechanisms of HCC initiation.

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Section: Methodsmentioning

confidence: 99%

Peritumoral overexpression of ZBP‑89 is associated with unfavorable disease‑free survival rates in patients with hepatocellular carcinoma following hepatectomy

et al. 2018

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“…Cirrhosis, the end-stage of hepatic fibrosis, is equivalent to stage 4 fibrosis in the Meta-analysis of Histological Data in Viral Hepatitis (METAVIR) system, or stages 5-6 in the Ishak scoring system [58], as well as in the newly introduced systems, including the Yale (Jain-Garcia), Laennec [59], and PIR systems [60].…”

Section: Liver Cirrhosismentioning

confidence: 99%

Quantification of liver function using gadoxetic acid-enhanced MRI

et al. 2020

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The introduction of hepatobiliary contrast agents, most notably gadoxetic acid (GA), has expanded the role of MRI, allowing not only a morphologic but also a functional evaluation of the hepatobiliary system. The mechanism of uptake and excretion of gadoxetic acid via transporters, such as organic anion transporting polypeptides (OATP1,3), multidrug resistance-associated protein 2 (MRP2) and MRP3, has been elucidated in the literature. Furthermore, GA uptake can be estimated on either static images or on dynamic imaging, for example, the hepatic extraction fraction (HEF) and liver perfusion. GA-enhanced MRI has achieved an important role in evaluating morphology and function in chronic liver diseases (CLD), allowing to distinguish between the two subgroups of nonalcoholic fatty liver diseases (NAFLD), simple steatosis and nonalcoholic steatohepatitis (NASH), and help to stage fibrosis and cirrhosis, predict liver transplant graft survival, and preoperatively evaluate the risk of liver failure if major resection is planned. Finally, because of its noninvasive nature, GA-enhanced MRI can be used for long-term follow-up and post-treatment monitoring. This review article aims to describe the current role of GA-enhanced MRI in quantifying liver function in a variety of hepatobiliary disorders.

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“…The grading and staging were done using modified histological activity index, the Ishak score. [28][29][30][31][32][33][34] Confluent necrosis of any degree in hepatitis B implies specific clinical events requiring attention. [29] The other features seen were steatosis, ballooning degeneration, bile ductular proliferation and cholestasis.…”

Section: Viral Hepatitismentioning

confidence: 99%

“…[28] All the scoring systems are almost equally effective for grading and staging, but the interaction between pathologists and hepatologists is important to obtain meaningful and reproducible results. [33,34] Chronic hepatitis E infection, though rare, can occur in the setting of immunosuppression. [35] Goyal R et al in their study of four patients with hepatitis E virus induced acute on chronic liver failure (ACLF) have stressed on effectiveness of ribavirin as a therapeutic agent for HEV induced ACLF.…”

Section: Viral Hepatitismentioning

confidence: 99%

Study of Liver Biopsy in Chronic Liver Diseases

Kulkarni

2018

APALM

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Background: Chronic liver disease (CLD)represents liver disorders of varying causes and severity in which hepatic inflammation and necrosis continue for at least 6 months.The treatment of cause leads to regression of fibrosis and parenchymal recovery. Liver biopsy is often used to establish the diagnosis, assess the severity of disease in CLD and its role is evolving with advances in medical technology. The objective was to study the histopathological pattern of injury in patients with CLD and thereby establish a possible etiologic diagnosis in correlation with clinical, biochemical and serologic findings. Methods: Thirty five cases of CLD with histopathological features of necroinflammation/fibrosis were studied for a period of five years. Along with demographics and laboratory parameters, sections were studied for the pattern and degree of injury.Grading and staging were done using standard systems. Results: Nonalcoholic fatty liver disease (31.42%) and alcoholic liver disease (25.71%) were the most common causes followed by viral hepatitis (11.42%) and drug induced liver injury (8.58%). One case each of autoimmune hepatitis and primary biliary cirrhosis were seen. A definitive diagnosis was not possible in six patients, and only a probable etiology was considered. Conclusion: The natural history of CLD is changing and is important to establish an etiological diagnosis. Despite the advances in diagnostic techniques, liver biopsy remains a valuable tool to establish the etiology and traditional descriptive reports still hold importance for the treatment and prognosis.However, it remains challenging and should be interpreted in the setting of clinical, biochemical, serological and radiological findings.

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S2068 Histopathological Study of Chronic Hepatitis B: A Comparative Study of Ishak and Metavir Scoring Systems

Cited by 10 publications

References 8 publications

Peritumoral overexpression of ZBP‑89 is associated with unfavorable disease‑free survival rates in patients with hepatocellular carcinoma following hepatectomy

Peritumoral overexpression of ZBP‑89 is associated with unfavorable disease‑free survival rates in patients with hepatocellular carcinoma following hepatectomy

Quantification of liver function using gadoxetic acid-enhanced MRI

Study of Liver Biopsy in Chronic Liver Diseases

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