S19 Does inhibin-B help us to confidently refuse diagnostic testicular bipsy in azoospermia?

Moradi, M.; Alemi, Mohsen; Izadi, Babak; Parhodah, F.; Asadi, Fatemeh Torkaman

doi:10.1016/s1569-9056(13)62052-7

Cited by 3 publications

(4 citation statements)

References 10 publications

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“…Moreover, it can be used in the evaluation of boys with nonpalpable gonads [7]. Inhibin B is another useful marker of normal testicular tissue; therefore, basal inhibin B measurement can be used as a reliable tool to assess both the existence and function of the testes and spermatogenesis afterwards [8][9][10].…”

Section: Review Articlementioning

confidence: 99%

In Children with 46, XY DSD; HCG Testing is not always the Best Answer for Testicular Function Assessment

Khater¹,

Raafat²

2022

jendocrdisord

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Hormonal levels are the hallmark for the assessment of testicular function in XY DSD (Disorders of sex development). Traditionally, it has relied on testosterone level increment after hCG (human Chorionic Gonadotropin) stimulation testing. More recently role of Sertoli cell hormones is more emphasized. Objectives: Evaluating the role of serum anti-mullerian hormone and inhibin B on function of the pre-pubertal testis without the need for hCG stimulation test. Method: The study was conducted in the Endocrinology Clinic in Alexandria University Children’s Hospital. All patients who present with XY DSD were tested for Testosterone (T), Dihydrotestosterone (DHT), Follicle Stimulating Hormone (FSH), Luteinizing Hormone (LH), Anti-Mullerian Hormone (AMH), inhibin B. All cases had hCG stimulation test. Results: The hCG stimulation test was done for 32 cases. There was significant positive correlation between serum testosterone levels before and after hCG stimulation test (p <0.001). Similarly, significant correlation was identified between basal AMH and testosterone increment after hCG stimulation (p <0.001) and between basal levels of AMH and inhibin (MCp= 0.025). Conclusion: Single measurement of basal AMH and/or inhibin B can detect the presence and function of testes by a reliable non-invasive way. Basal AMH assessment is an important tool to distinguish between cryptorchidism and anorchia. hCG test is needed in the work-up of patients with inconclusive results.

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Section: Review Articlementioning

confidence: 99%

In Children with 46, XY DSD; HCG Testing is not always the Best Answer for Testicular Function Assessment

Khater¹,

Raafat²

2022

jendocrdisord

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“…[7] Inhibin B is another useful marker of normal testicular tissue; therefore, basal inhibin B measurement can be used as a reliable tool to assess both the existence and function of the testes and spermatogenesis afterwards. [8][9][10] However, the value of AMH and inhibin B in evaluating cases with XY DSD has been challenged. [2,11] We report our experience of the role of serum AMH and inhibin B in assessing the function of the pre-pubertal testis without the need for hCG stimulation test.…”

Section: Introductionmentioning

confidence: 99%

In Children with 46, XY DSD; HCG Testing Is Not Always the Best Answer for Testicular Function Assessment

Raafat

Khater

2021

Preprint

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Hormonal levels are the hallmark for the assessment of testicular function in XY DSD (Disorders of sex development). Traditionally, it has relied on testosterone level increment after hCG (human chorionic gonadotropin) stimulation testing. More recently role of Sertoli cell hormones is more emphasized.Objectives: Evaluating the role of serum anti-mullerian hormone and inhibin B on function of the pre-pubertal testis without the need for hCG stimulation test.Method: The study was conducted in the Endocrinology Clinic in Alexandria University Children's Hospital. All patients who present with XY DSD were tested for testosterone (T), dihydrotestosterone (DHT), Follicle stimulating hormone (FSH), luteinizing hormone (LH), anti-mullerian hormone (AMH), inhibin B. All cases had hCG stimulation test.Results: The hCG stimulation test was done for 32 cases. There was significant positive correlation between serum testosterone levels before and after hCG stimulation test (p <0.001). Similarly, significant correlation was identified between basal AMH and testosterone increment after hCG stimulation (p <0.001) and between basal levels of AMH and inhibin (MCp= 0.025).Conclusion: Single measurement of basal AMH and/or inhibin B can detect the presence and function of testes by a reliable non-invasive way. Basal AMH assessment is an important tool to distinguish between cryptorchidism and anorchia. hCG test is needed in the work-up of patients with inconclusive results.

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“…Moradi et al (2012) исследовали 41 пациента с азооспермией с целью изучения вопроса, может ли измерение ингибина В снизить количество ненужных хирургических тестикулярных биопсий у мужчин с азоо-спермией. Сперматозоиды нашли в 29 % биоптатов, и в 100 % случаев уровень ингибина В у этих пациентов составил 100 пг/мл, а уровень ФСГ был в 2 раза ниже нормы (p = 0,001).…”

unclassified

“…Уровень ФСГ коррелировал только с обструктивной азооспермией (p = 0,001). Авторы за-ключили, что при уровне ФСГ в 2 раза ниже нормы и концентрации ингибина В ниже 100 пг/мл биопсию яичек проводить нецелесообразно [16].…”

unclassified

Prognostic significance of ingibin B with infertile patients (review of references)

Кадыров¹,

Moskvichev²,

Astakhova³

2015

Androl. genit. hir.

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S19 Does inhibin-B help us to confidently refuse diagnostic testicular bipsy in azoospermia?

Cited by 3 publications

References 10 publications

In Children with 46, XY DSD; HCG Testing is not always the Best Answer for Testicular Function Assessment

In Children with 46, XY DSD; HCG Testing is not always the Best Answer for Testicular Function Assessment

In Children with 46, XY DSD; HCG Testing Is Not Always the Best Answer for Testicular Function Assessment

Prognostic significance of ingibin B with infertile patients (review of references)

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