S1738 Role of D2 Dopamine Receptors in the Pathogenesis of Experimental Ulcerative Colitis: Implication of Colonic Vascular Permeability

Evaluation of central and peripheral effects of doxepin on acetic acid-induced colitis in rat and the involved mechanisms

“…It binds strongly to the histamine H 1 and H 2 receptors (Shibuya et al, 2012[ 48 ]; Ahles et al, 1984[ 1 ]; Shimamura et al, 2011[ 49 ]) and has some antagonistic effects on 5-HT, alpha 1 adrenergic and muscarinic receptors (Singh and Becker, 2007[ 50 ]). The roles of these mediators in the pathogenesis of colitis have been previously investigated (Fogel et al, 2005[ 12 ]; Ghia et al, 2009[ 13 ]; Tolstanova et al, 2010[ 54 ]; Xie and He, 2005[ 58 ]).…”

“…The roles of some nervous systems and mediators in the pathogenesis of colitis such as sympathetic nervous system (SNS) (Straub et al, 2006[ 51 ]), histamine (Fogel et al, 2005[ 12 ]; Xie and He, 2005[ 58 ]), serotonin (Ghia et al, 2009[ 13 ]; Shajib and Khan, 2015[ 47 ]) and dopamine (Tolstanova et al, 2010[ 54 ]), make doxepin as a good candidate for therapy of inflammatory conditions such as IBD.…”