S1314 The Effect of Probiotic Mixture on the Symptoms and Fecal Microbiota in Diarrhea-Dominant Irritable Bowel Syndrome: Randomized, Double-Blind, Placebo-Controlled Trial

Ki, Bong; Choi, Chang Hwan; Baek, Eun Kyung; Lee, Hyun Woong; Hyuk, Jae; Chang, Sae Kyung

doi:10.1016/s0016-5085(10)61030-x

Cited by 57 publications

(96 citation statements)

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“…One study included patients with functional gastrointestinal disorders, ie, with diarrhea but not constipation and not necessarily suffering from abdominal pain, 72 one was restricted to constipation predominant IBS (IBS-C) patients 65 and 4 included only diarrhea predominant IBS (IBS-D) patients. 62,68,69,80 All studies claimed the use of Rome (II or III) criteria, nevertheless, a more detailed description of the patient population (the number of IBS-D, IBS-C, and mixed IBS [IBS-M] patients) was lacking. Treatment duration varied from 7 days to 6 months, thus not fulfilling Rome criteria for treatment duration in many cases, 17 with the majority of studies assessing treatment results after 8 weeks.…”

Section: Study Characteristicsmentioning

confidence: 99%

Probiotic Therapy of the Irritable Bowel Syndrome: Why Is the Evidence Still Poor and What Can Be Done About It?

Mazurak

Broelz²,

Storr

et al. 2015

J Neurogastroenterol Motil

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Background/AimsDespite numerous randomized clinical trials and meta-analyses, there is no increased evidence for the efficacy of probiotics in the treatment of irritable bowel syndrome (IBS). We review this evidence, identify and analyse the reasons for this lack of evidence and propose methodological improvements for future studies. MethodsBased on a literature search, we identified 56 papers that matched the purpose of our analyses. Twenty-seven studies used multi-species bacterial preparations and 29 used single-strain probiotics. They were analysed regarding patients included, treatment duration, probiotic dosage, and outcome measures. ResultsTrials in both groups suffered from heterogeneity with respect to probiotic concentration, duration of treatment, and other methodological issues (crossover design and underpowered studies). This heterogeneity did not allow the application of a meta-analytic approach and a systematic review was therefore performed instead. Multi-strain preparations combined 2 to 8 different bacterial subspecies, mostly lactobacilli or bifidobacteria, and used variable lengths of treatments. Overall, more than 50% of trials presented negative outcomes. The majority of the single-strain probiotic trials employing lactobacilli or Saccharomyces were negative, whereas trials employing bifidobacteria showed positive results. ConclusionsThe heterogeneity of the studies of probiotics in IBS questions the value of meta-analyses. The use of different bacterial strains and different mixtures of these strains, as well as different dosages, are the main contributors to this heterogeneity. Current data provides limited evidence for the efficacy of a small number of single-strain probiotics in IBS (mostly bifidobacteria) and

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Section: Study Characteristicsmentioning

confidence: 99%

Probiotic Therapy of the Irritable Bowel Syndrome: Why Is the Evidence Still Poor and What Can Be Done About It?

Mazurak

Broelz²,

Storr

et al. 2015

J Neurogastroenterol Motil

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“…Placebo-controlled studies have shown that patients using various probiotic mixtures (including B. lactis) have a significantly greater number of improvements in stool consistency (12,13) and in IBS symptoms such as abdominal pain (12,14,15) satisfaction with bowel habits, quality of life (14), and fullness (13,15) than those in the control groups. Furthermore, these studies have shown that a significantly greater number of patients in the probiotic groups had full recovery when compared to the placebo groups (12,13). Patients taking probiotics did not have any significant increases in intestinal microbiota or changes in levels of the inflammatory marker C-reactive protein (15).…”

Section: Discussionmentioning

confidence: 99%

Efficacy of synbiotic, probiotic, and prebiotic treatments for irritable bowel syndrome in children: A randomized controlled trial

Baştürk

Artan²,

Yılmaz³

2020

Turk J Gastroenterol

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“…2a). In contrast, no statistically significant differences were found in the medians before and after intake for subjects consuming viable cell samples or those consuming placebo samples, suggesting that test food intake was associated with the enhancement of NK-cell activity only in the dead cell intake group (22,23).…”

Section: Effects Of Test Food Samples On Feces Form and Feeling Aftermentioning

confidence: 95%

Effects of Intake of Pickles Containing Lactobacillus brevis on Immune Activity and Bowel Symptoms in Female Students

Takii

Nishimura

Yoshida-Yamamoto

et al. 2013

J Nutr Sci Vitaminol

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Summary Forty-four female students with a tendency for constipation (mean age, 20.263.3 y) were asked to consume 30 g test pickles daily for 2 wk and were divided into 3 groups: viable-cell intake subjects (n514, 3.0310 5 colony-forming units of viable LAB (lactic acid bacteria) cells per sample), dead-cells intake subjects (n515, viable cells were heat sterilized), and placebo-intake subjects (n515, LAB removed from the pickles). g-Aminobutyric acid content of 75.163.2 mg per sample was noted, with no marked difference between samples containing viable and dead cells. Natural killer (NK)-cell activity (% specific lysis) in serum from dead-cell intake subjects was 37.5617.0% before the start of the test-food intake and 47.7620.1% after intake, indicating statistically significant effects (p,0.01). However, viable-cell intake and placebo intake subjects showed no statistically significant difference. The number of days with bowel movements significantly increased from 3.861.5 to 4.961.8 d in the dead-cell intake group, whereas a slight change from 4.661.5 to 5.161.7 d was observed in the viable-cell intake group. Additionally, the feeling of incomplete evacuation fell and a refreshed feeling increased among the subjects with constipation. Thus, marked enhancement of NK-cell activity and improved bowel symptoms were observed in subjects consuming pickles containing dead LAB cells.

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S1314 The Effect of Probiotic Mixture on the Symptoms and Fecal Microbiota in Diarrhea-Dominant Irritable Bowel Syndrome: Randomized, Double-Blind, Placebo-Controlled Trial

Cited by 57 publications

References 0 publications

Probiotic Therapy of the Irritable Bowel Syndrome: Why Is the Evidence Still Poor and What Can Be Done About It?

Probiotic Therapy of the Irritable Bowel Syndrome: Why Is the Evidence Still Poor and What Can Be Done About It?

Efficacy of synbiotic, probiotic, and prebiotic treatments for irritable bowel syndrome in children: A randomized controlled trial

Effects of Intake of Pickles Containing Lactobacillus brevis on Immune Activity and Bowel Symptoms in Female Students

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