Efficacy of synbiotic, probiotic, and prebiotic treatments for irritable bowel syndrome in children: A randomized controlled trial

Baştürk, Ahmet; Artan, Reha; Yılmaz, Aygen

doi:10.5152/tjg.2016.16301

Cited by 66 publications

(67 citation statements)

References 28 publications

(29 reference statements)

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“…Fermentable carbohydrates can have a positive role in health, and elimination should only occur when it translates to successful symptom resolution. Oligosaccharides such as fructans and galactooligosaccharides, for example, are fermentable fibers that may promote symptom improvement in some patients through mechanisms related to their prebiotic properties . Prebiotics are foods that assist in the growth of beneficial bacteria in the gut microbiome, and microbiome dysbiosis is another proposed etiology for GI symptoms in IBS.…”

Section: Discussionmentioning

confidence: 99%

“…Oligosaccharides such as fructans and galactooligosaccharides, for example, are fermentable fibers that may promote symptom improvement in some patients through mechanisms related to their prebiotic properties. 10 Prebiotics are foods that assist in the growth of beneficial bacteria in the gut microbiome, and microbiome dysbiosis is another proposed etiology for GI symptoms in IBS. Further delineation of IBS subtypes in study populations should also be considered in the assessment of response to fermentable carbohydrate elimination, especially in terms of outcomes related to stool form or frequency.…”

Section: Implications For Practicementioning

confidence: 99%

“…These subtypes include constipation‐predominant (IBS‐C), diarrhea‐predominant (IBS‐D), mixed (IBS‐M), and unspecified IBS (IBS‐U) . The most common subtypes of IBS in the pediatric population are IBS‐C (43%–75%) and IBS‐U (0%–43%) …”

Section: Introductionmentioning

confidence: 99%

“…9 The most common subtypes of IBS in the pediatric population are IBS-C (43%-75%) and IBS-U (0%-43%). [9][10][11][12][13][14] The pathophysiology of IBS in pediatric patients is not completely understood. One proposed cause is dysfunction in the gut-brain axis.…”

Section: Introductionmentioning

confidence: 99%

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Elimination of Fermentable Carbohydrates to Reduce Gastrointestinal Symptoms in Pediatric Patients With Irritable Bowel Syndrome: A Narrative Review

2019

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Irritable bowel syndrome (IBS) is classified as a functional gastrointestinal (GI) disorder characterized by abdominal pain, bloating, and changes in bowel function. Although the pathophysiology of IBS is incompletely understood, fermentable carbohydrates are implicated as a potential cause of symptoms. An elimination diet, such as a low‐FODMAP (fermentable oligosaccharides, disaccharides, monosaccharides, and polyols) diet, represents a potential intervention for reducing GI symptoms in patients with IBS. The role of fermentable carbohydrates in symptom onset is well studied in adult patients with IBS; however, less research exists in the pediatric population. This review sought to explore evidence for the role of dietary fermentable carbohydrate elimination to reduce GI symptoms (abdominal pain, stool changes, abdominal bloating) in children and adolescents (4–19 years of age) diagnosed with IBS based on Rome III or IV criteria. Five studies of neutral to positive quality rating were identified and analyzed using the Academy of Nutrition and Dietetics Evidence Analysis Process. These studies demonstrate that dietary elimination of fermentable carbohydrates, such as through a low‐FODMAP diet, reduces the severity of 1 or more GI symptoms in about one‐quarter to one‐half of pediatric patients with IBS. Patients without improvement are considered “nonresponders” and may require an alternative intervention. More research is needed to establish the best way to identify patients who would respond to elimination diets vs other IBS treatment strategies.

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Section: Discussionmentioning

confidence: 99%

Section: Implications For Practicementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Elimination of Fermentable Carbohydrates to Reduce Gastrointestinal Symptoms in Pediatric Patients With Irritable Bowel Syndrome: A Narrative Review

2019

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“…Although a mechanism of action is not fully understood, probiotics are also believed to exert their effect on IBS symptomatology by modulating the intestinal flora and the intestinal immune response 58 . In a randomized, double-blind, controlled study by Baştürk et al, 71 children with IBS between the ages of 4 and 16 years were divided into three groups, in which the first received a probiotic treatment, the second received a synbiotic treatment, and the third group received a prebiotic treatment 59 . The study found that the probiotic, synbiotic, and prebiotic treatments significantly improved IBS symptoms after a twice-daily 4-week treatment 59 .…”

Section: Management Of Disaccharidase Deficiency In Ibsmentioning

confidence: 99%

The relationship between disaccharidase deficiencies and irritable bowel syndrome in childre - A literature review

Puertolas¹,

Pagan²,

Andino³

et al. 2019

NGL

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Irritable bowel syndrome (IBS) is a highly prevalent functional gastrointestinal disorder whose etiology is yet to be completely understood. It classically presents with non-specific symptoms such as abdominal pain and diarrhea. There is significant overlap between these symptoms and those observed in patients with disaccharidase deficiencies. Despite the appreciable literature available on the effects of lactase deficiency in IBS, some of which will be reviewed below, deficiencies of the other disaccharidases, such as sucrase, maltase, and isomaltase, are less commonly considered in patients presenting with symptoms resembling IBS. Multiple treatment modalities have been proposed; however, the lack of consistency in treatment, as well as the absence of a more meticulous diagnostic tool, has made both disorders difficult to distinguish. The objective of this review is to evaluate and summarize the current scientific literature on the possible role of disaccharidase deficiencies on the pathophysiology of IBS symptoms and what implications this has for management.

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Probiotics for management of functional abdominal pain disorders in children

Wallace

Gordon

Sinopoulou

et al. 2023

Cochrane Database of Systematic Reviews

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Efficacy of synbiotic, probiotic, and prebiotic treatments for irritable bowel syndrome in children: A randomized controlled trial

Cited by 66 publications

References 28 publications

Elimination of Fermentable Carbohydrates to Reduce Gastrointestinal Symptoms in Pediatric Patients With Irritable Bowel Syndrome: A Narrative Review

Elimination of Fermentable Carbohydrates to Reduce Gastrointestinal Symptoms in Pediatric Patients With Irritable Bowel Syndrome: A Narrative Review

The relationship between disaccharidase deficiencies and irritable bowel syndrome in childre - A literature review

Probiotics for management of functional abdominal pain disorders in children

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