S100A8 and S100A9 proteins are expressed by human corneal stromal dendritic cells

Wilkinson, Adam C.; Kawaguchi, Naomi; Geczy, Carolyn L.; Girolamo, Nick Di

doi:10.1136/bjophthalmol-2016-308827

Cited by 9 publications

(4 citation statements)

References 22 publications

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“…In contrast, S100A8/A9 also have anti-in ammatory functions in various microenvironments. S100A8/A9 inhibit the differentiation and functioning of dendritic cells (30), induce myeloid-derived suppressor cells (31), and increase the functions of regulatory T-lymphocytes (32). In our study, we found a correlation between elevated levels of S100A8/A9 and decreased survival rates in patients suffering from IPF.…”

Section: Discussionsupporting

confidence: 58%

Prognostic significance of peripheral blood S100A12, S100A8, S100A9 concentrations in idiopathic pulmonary fibrosis

Ding

Luan

Xue

et al. 2023

Preprint

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Background S100A12, S100A8, and S100A9 are considered to be biomarkers of inflammatory diseases; however, their roles in idiopathic pulmonary fibrosis (IPF) remain unclear. In this study, the levels of S100A12, S100A8, and S100A9 in the serum of patients with IPF were analyzed to evaluate the significance of these three factors in the development and prognosis of IPF. Methods Differentially expressed genes were screened using the GEO2R tool. Serum S100A12 and S100A8/9 protein levels were assessed using enzyme-linked immunosorbent assays. Pearson’s correlation coefficient, Kaplan–Meier analysis, Cox regression analysis, and functional enrichment analysis were used to evaluate the relationship between these protein levels and clinical parameters or prognosis. Results The most important genes co-expressed with S100A12 were S100A8 and S100A9. Serum S100A12, S100A8, and S100A9 concentrations in patients with IPF were significantly higher than those in age-matched healthy controls. The prognosis of patients with IPF with higher serum S100A12, S100A8, and S100A9 concentrations was significantly worse than that of those with lower serum concentrations. Conclusions Serum S100A12, S100A8, and S100A9 are promising circulating biomarkers that may provide potentially valuable clinical aid for the prognosis of patients with IPF. However, further multicenter clinical trials with larger sample sizes are needed in the future to confirm their clinical application value.

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Section: Discussionsupporting

confidence: 58%

Prognostic significance of peripheral blood S100A12, S100A8, S100A9 concentrations in idiopathic pulmonary fibrosis

Ding

Luan

Xue

et al. 2023

Preprint

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show abstract

“…These cells were positive for CD45, HLA-DR, and CD11c, which are characteristic markers of DCs. Thus, expression of A8 and A9 may help to distinguish between subpopulations of DCs which are present in different regions of the cornea and may impact on their maturation state [ 117 ].…”

Section: Effects Of Uv Irradiation To the Limbal Niche: Pterygium mentioning

confidence: 99%

The Role of Limbal Epithelial Stem Cells in Regulating Corneal (Lymph)angiogenic Privilege and the Micromilieu of the Limbal Niche following UV Exposure

Notara

Lentzsch

Coroneo

et al. 2018

Stem Cells International

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The cornea is a clear structure, void of blood, and lymphatic vessels, functioning as our window to the world. Limbal epithelial stem cells, occupying the area between avascular cornea and vascularized conjunctiva, have been implicated in tissue border maintenance, preventing conjunctivalisation and propagation of blood and lymphatic vessels into the cornea. Defects in limbal epithelial stem cells are linked to corneal neovascularisation, including lymphangiogenesis, chronic inflammation, conjunctivalisation, epithelial abnormalities including the presence of goblet cells, breaks in Bowman's membrane, persistent epithelial defects and ulceration, ocular surface squamous neoplasia, lipid keratopathy, pain, discomfort, and compromised vision. It has been postulated that pterygium is an example of focal limbal deficiency. Previous reports showing changes occurring in limbal epithelium during pterygium pathogenesis suggest that there is a link to stem cell damage. In this light, pterygium can serve as a model disease of UV-induced stem cell damage also characterised by corneal blood and lymphangiogenesis. This review focuses on the role of corneal and limbal epithelial cells and the stem cell niche in maintaining corneal avascularity and corneal immune privilege and how this may be deregulated following UV exposure. We present an overview of the PUBMED literature in the field as well as recent work from our laboratories.

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“…Constitutive expression of S100A7 has been reported in cornea, conjunctiva, nasolacrimal ducts, and lacrimal glands. S100A8 and S100A9 were also found to be expressed by human corneal stromal cells ( Wilkinson et al, 2016 ). Ocular fluid also contains human neutrophil peptides (hNP-1 and -2), hBD-1, hBD-2, hBD-3, lactoferrin, lysozyme, and transferrin during normal conditions ( Silva et al, 2013 ).…”

Section: Antimicrobial Peptidesmentioning

confidence: 99%

Alternative Therapeutic Interventions: Antimicrobial Peptides and Small Molecules to Treat Microbial Keratitis

et al. 2021

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Microbial keratitis is a leading cause of blindness worldwide and results in unilateral vision loss in an estimated 2 million people per year. Bacteria and fungus are two main etiological agents that cause corneal ulcers. Although antibiotics and antifungals are commonly used to treat corneal infections, a clear trend with increasing resistance to these antimicrobials is emerging at rapid pace. Extensive research has been carried out to determine alternative therapeutic interventions, and antimicrobial peptides (AMPs) are increasingly recognized for their clinical potential in treating infections. Small molecules targeted against virulence factors of the pathogens and natural compounds are also explored to meet the challenges and growing demand for therapeutic agents. Here we review the potential of AMPs, small molecules, and natural compounds as alternative therapeutic interventions for the treatment of corneal infections to combat antimicrobial resistance. Additionally, we have also discussed about the different formats of drug delivery systems for optimal administration of drugs to treat microbial keratitis.

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S100A8 and S100A9 proteins are expressed by human corneal stromal dendritic cells

Abstract: A8 and A9 expression may distinguish between subpopulations of DC that reside in different regions of the human cornea and may influence their maturation status.

Cited by 9 publications

References 22 publications

Prognostic significance of peripheral blood S100A12, S100A8, S100A9 concentrations in idiopathic pulmonary fibrosis

Prognostic significance of peripheral blood S100A12, S100A8, S100A9 concentrations in idiopathic pulmonary fibrosis

The Role of Limbal Epithelial Stem Cells in Regulating Corneal (Lymph)angiogenic Privilege and the Micromilieu of the Limbal Niche following UV Exposure

Alternative Therapeutic Interventions: Antimicrobial Peptides and Small Molecules to Treat Microbial Keratitis

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