S100A8/A9 (Calprotectin), Interleukin-6, and C-Reactive Protein in Obesity and Diabetes before and after Roux-en-Y Gastric Bypass Surgery

Lylloff, Louise; Bathum, Lise; Madsbad, Sten; Grundtvig, Josefine; Nordgaard-Lassen, Inge; Fenger, Mogens

doi:10.1159/000478097

Cited by 20 publications

(16 citation statements)

References 25 publications

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“…S100A8/A9 circulating levels high were related to a persistent diabetes status post-BS. Decreased levels of circulating S100A8/A9 were observed in diabetics patients before but not after BS and in nondiabetic patients, but not in diabetic patients before and after BS [56]. Moreover, reports on studies carried out with mice and humans suggest that S100A8 is involved in the recruitment of AT macrophages [36,57].…”

Section: Discussionmentioning

confidence: 88%

Beneficial Effects of Bariatric Surgery-Induced by Weight Loss on the Proteome of Abdominal Subcutaneous Adipose Tissue

Varela-Rodríguez

Juiz-Valiña

Varela

et al. 2020

JCM

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Bariatric surgery (BS) is the most effective treatment for obesity and has a positive impact on cardiometabolic risk and in the remission of type 2 diabetes. Following BS, the majority of fat mass is lost from the subcutaneous adipose tissue depot (SAT). However, the changes in this depot and functions and as well as its relative contribution to the beneficial effects of this surgery are still controversial. With the aim of studying altered proteins and molecular pathways in abdominal SAT (aSAT) after body weight normalization induced by BS, we carried out a proteomic approach sequential window acquisition of all theoretical mass spectra (SWATH-MS) analysis. These results were complemented by Western blot, electron microscopy and RT-qPCR. With all of the working tools mentioned, we confirmed that after BS, up-regulated proteins were associated with metabolism, the citric acid cycle and respiratory electron transport, triglyceride catabolism and metabolism, formation of ATP, pyruvate metabolism, glycolysis/gluconeogenesis and thermogenesis among others. In contrast, proteins with decreased values are part of the biological pathways related to the immune system. We also confirmed that obesity caused a significant decrease in mitochondrial density and coverage, which was corrected by BS. Together, these findings reveal specific molecular mechanisms, genes and proteins that improve adipose tissue function after BS characterized by lower inflammation, increased glucose uptake, higher insulin sensitivity, higher de novo lipogenesis, increased mitochondrial function and decreased adipocyte size.

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Section: Discussionmentioning

confidence: 88%

Beneficial Effects of Bariatric Surgery-Induced by Weight Loss on the Proteome of Abdominal Subcutaneous Adipose Tissue

Varela-Rodríguez

Juiz-Valiña

Varela

et al. 2020

JCM

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“…Recent studies, suggest that calprotectin could serve as an important prognostic factor for cardiovascular and cardiometabolic diseases, which in turn develop from a low-grade chronic inflammation [13]. In this sense, serum calprotectin was recently described as a novel marker of obesity in adults [12][13][14].…”

Section: Discussionmentioning

confidence: 99%

“…In adults, the study on the relation between calprotectin and insulin resistance and type 2 diabetes mellitus has conflicting results [12]: one study did not find any correlation between circulating S100A8/A9 and markers of glucose metabolism [14], whereas other researchers have found S100A8/A9 to be correlated to insulin resistance and suggestive of being involved the development of insulin resistance [29,32].…”

Section: Discussionmentioning

confidence: 99%

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Serum Calprotectin Level in Children: Marker of Obesity and its Metabolic Complications

et al. 2018

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Aim: Elevated calprotectin levels have been reported in obese adults but have not been evaluated in pediatric population. We investigated the characteristics of serum calprotectin in overweight and obese children and its association with metabolic comorbidities. Methods: We enrolled 131 children (11.7 ± 4.1 years). According to body mass index (BMI), the subjects were divided into 3 groups: obese > 95th percentile; overweight BMI 75th–95th percentile, and normal weight BMI < 75th percentile. Patients were classified as having Metabolic Syndrome if they met 3 or more of the following criteria for age and sex: BMI > 97th percentile, triglycerides > 95th percentile, high-density lipoprotein cholesterol < 5th percentile, systolic and/or diastolic blood pressure > 95th percentile, and impaired glucose tolerance. In all patients, calprotectin serum levels were also detected. Results: Calprotectin was higher in obese and overweight children than normal weight subjects (p < 0.001), with calprotectin in females being significantly higher than in males (p = 0.04). Increased calprotectin was related to pathological fasting blood glucose (p < 0.001) and insulin resistance (p = 0.03), while BMI (p = 0.001), and diastolic pressure (p = 0.001) are independent factors for increased calprotectin. Conclusions: Our findings confirm the association between increased calprotectin and obesity also in children and suggest the potential utility of this biomarker in the monitoring of its metabolic complications.

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“…показали, что именно его уровень наряду с IL-6 коррелирует с основными показателями улучшения метаболизма углеводов (инсулин и глюкоза в крови натощак и др.) [35].…”

Section: цитокины адипокиныunclassified

Multiple effects of bariatric surgery on human biochemical status

Sushentseva¹,

Apalko²,

Vasilyev³

et al. 2019

Obes. metabol.

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Beneficial effect of bariatric surgery is expressed not only in reducing body weight, but also in improving the functioning of the body as a whole. On the one hand, numerous studies devoted to the investigations of specific mechanisms of the influence of bariatric surgery on the general condition of an organism testify to the enormous interest of scientists in this problem. On the other hand, the range of changes is so vast that it covers almost all physiological and biochemical processes. The most noticeable response to bariatric surgery is from the digestive (including the composition of the microbiota), immune (reducing the level of systemic and local inflammation), cardiovascular (reducing the risks of atherosclerosis and other diseases) systems. Partial or complete compensation of type 2 diabetes mellitus and metabolic syndrome also occurs. Among the variety of data, there is insufficient research on only standard biomarkers: leptin, C-reactive protein, interleukin 6, etc. A detailed study of the profiles of both circulating biomarkers and local ones is necessary. At the same time, it is obligate to continue to accumulate evidence on the positive effect of bariatric surgery, since this type of surgical intervention has come into practice relatively recently. Unfortunately, at the present time in Russia bariatric surgery is not an affordable and popular treatment for morbid obesity (MO). Nevertheless, it is extremely important to change the current situation, since bariatric treatment is an optimal and effective solution to socially significant diseases such as MO or type 2 diabetes mellitus.

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S100A8/A9 (Calprotectin), Interleukin-6, and C-Reactive Protein in Obesity and Diabetes before and after Roux-en-Y Gastric Bypass Surgery

Cited by 20 publications

References 25 publications

Beneficial Effects of Bariatric Surgery-Induced by Weight Loss on the Proteome of Abdominal Subcutaneous Adipose Tissue

Beneficial Effects of Bariatric Surgery-Induced by Weight Loss on the Proteome of Abdominal Subcutaneous Adipose Tissue

Serum Calprotectin Level in Children: Marker of Obesity and its Metabolic Complications

Multiple effects of bariatric surgery on human biochemical status

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