S100A4-induced cell motility and metastasis is restricted by the Wnt/β-catenin pathway inhibitor calcimycin in colon cancer cells

Sack, Ulrike; Walther, Wolfgang; Scudiero, Dominic A.; Selby, Mike; Aumann, Jutta; Lemos, Clara; Fichtner, Iduna; Schlag, Peter M.; Shoemaker, Robert H.; Stein, Ulrike

doi:10.1091/mbc.e10-09-0739

Cited by 107 publications

(102 citation statements)

References 40 publications

(55 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…S100A4 is a small Ca 2+ -binding protein involved in several biological functions enhancing the metastatic capacity of cancer cells [3]. The mechanisms causing S100A4-induced migration [4], invasion [5,6] and angiogenesis [7] are starting to be unraveled, but exact knowledge is still to be determined [8]. We, and others, have convincingly demonstrated that the protein can induce expression of matrix metalloproteinases (MMPs) and thereby enhance the tumor cells' ability to invade surrounding tissue [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Prognostic significance of S100A4-expression and subcellular localization in early-stage breast cancer

Egeland

Boye

Park

et al. 2017

Breast Cancer Res Treat

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Prognostic significance of S100A4-expression and subcellular localization in early-stage breast cancer

Egeland

Boye

Park

et al. 2017

Breast Cancer Res Treat

View full text Add to dashboard Cite

“…S100A4 is involved in tumor metastasis by affecting cell growth, invasion and motility (16,17). Our previous study reported a significant correlation between S100A4 expression levels and LSCC (11).…”

Section: Discussionmentioning

confidence: 98%

RNA interference targeting inhibition of S100A4 suppresses cell growth and promotes apoptosis in human laryngeal carcinoma Hep-2 cells

Liu

et al. 2014

Molecular Medicine Reports

View full text Add to dashboard Cite

Abstract. S100A4 is a small Ca 2+ binding protein that belongs to the S100 family and is involved in a number of cellular functions, including cell cycle control, proliferation, apoptosis, and has a significant role in angiogenesis and neurite extension. However, the exact function and mechanism of S100A4 in laryngeal carcinogenesis remains to be elucidated. The present study was designed to investigate the potential use of RNA interference to inhibit S100A4 expression and activation, as well as the subsequent effect on human laryngeal cancer cell growth and apoptosis. The present study demonstrated that knockdown of S100A4 decreased the proliferation and growth of the human laryngeal cancer Hep-2 cell line. The percentages of the apoptotic cells were 4.23±1.22, 4.92±1.85 and 11.70±4.02% in the control, negative control and S100A4 short hairpin RNA (shRNA) groups, respectively, indicating significant differences among the different groups. The S100A4-mediated induction of apoptosis was demonstrated to be associated with the activation of caspase-3, caspase-8 and caspase-9. Intratumoral injection of S100A4-shRNA inhibited tumor growth in nude mice. Thus, knockdown of S100A4 inhibited the progression of laryngeal squamous carcinoma, decreased proliferation and promoted apoptosis. S100A4 is a potential candidate for therapeutic targeting of laryngeal carcinoma cells.

show abstract

“…S100A4 играет важную роль в таких клеточных процессах, как миграция, инвазия, адгезия и ангиогенез, которые лежат в основе образования метастазов. Показано, что при раке толстой кишки экспрессия S100A4 в опухолях позволяет прогнозировать развитие метастазов [34]. Ингибиторы экспрессии S100A4, которые угнетали бы S100A4-опосредованное метастазирование, не известны.…”

Section: москалева и дрunclassified

Molecular mechanisms of niclosamide antitumor activity

et al. 2015

View full text Add to dashboard Cite

In this review the recent data regarding the antitumor activity of niclosamide and the molecular mechanisms of its antitumor activity are presented. Niclosamide has been used in the clinic for the treatment of intestinal parasite infections. In recent years in several screening investigations of various drugs and chemical compounds niclosamide was identified as a potential anticancer agent. Niclosamide not only inhibits the Wnt/b-catenin, mTORC1, STAT3, NF-kB and Notch signaling pathways, but also targets mitochondria in cancer cells to induce growth inhibition and apoptosis. A number of studies have established the anticancer activity of niclosamide in both in vitro and in vivo in xenotransplantation models using human tumors and immunodeficient mice. It is important that niclosamide is active not only against tumor cells but also cancer stem cells. Normal cells are resistant to niclosamide. The accumulated experimental data suggest niclosamide is a promising drug for the treatment of various types of cancer.

show abstract

S100A4-induced cell motility and metastasis is restricted by the Wnt/β-catenin pathway inhibitor calcimycin in colon cancer cells

Abstract: Calcimycin restricts Wnt/β-catenin–regulated S100A4 expression, leading to reduced S100A4-mediated cell migration and invasion in colon cancer cells, as well as to inhibition of metastasis formation in xenografted mice.

Cited by 107 publications

References 40 publications

Prognostic significance of S100A4-expression and subcellular localization in early-stage breast cancer

Prognostic significance of S100A4-expression and subcellular localization in early-stage breast cancer

RNA interference targeting inhibition of S100A4 suppresses cell growth and promotes apoptosis in human laryngeal carcinoma Hep-2 cells

Molecular mechanisms of niclosamide antitumor activity

Contact Info

Product

Resources

About