S100 Proteins in Autoinflammation

Holzinger, Dirk; Kessel, Christoph; Foell, Dirk

doi:10.1007/978-3-319-98605-0_9

Cited by 4 publications

(4 citation statements)

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“…S100A10 seems to be the only family member who is active in a calcium-independent manner, as it lacks a Ca 2+ -binding site and remains in an open conformation when calcium is absent [ 5 , 7 , 13 ]. Besides calcium, some S100 proteins, for example, S100A7, S100A12, and S100B are capable of binding other divalent metal ions such as zinc (Zn 2+ ), copper (Cu 2+ ), and manganese (Mn 2+ ), which is thought to play a role in the formation of oligomers [ 4 , 14 ]. Moreover, the sequestering of nutrient transition metals, such as Zn 2+ and Mn 2+ , leads to the growth inhibition of microbial pathogens [ 6 ].…”

Section: The S100 Familymentioning

confidence: 99%

Friend or Foe: S100 Proteins in Cancer

Allgöwer

Kretz

Karstedt

et al. 2020

Cancers

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S100 proteins are widely expressed small molecular EF-hand calcium-binding proteins of vertebrates, which are involved in numerous cellular processes, such as Ca2+ homeostasis, proliferation, apoptosis, differentiation, and inflammation. Although the complex network of S100 signalling is by far not fully deciphered, several S100 family members could be linked to a variety of diseases, such as inflammatory disorders, neurological diseases, and also cancer. The research of the past decades revealed that S100 proteins play a crucial role in the development and progression of many cancer types, such as breast cancer, lung cancer, and melanoma. Hence, S100 family members have also been shown to be promising diagnostic markers and possible novel targets for therapy. However, the current knowledge of S100 proteins is limited and more attention to this unique group of proteins is needed. Therefore, this review article summarises S100 proteins and their relation in different cancer types, while also providing an overview of novel therapeutic strategies for targeting S100 proteins for cancer treatment.

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Section: The S100 Familymentioning

confidence: 99%

Friend or Foe: S100 Proteins in Cancer

Allgöwer

Kretz

Karstedt

et al. 2020

Cancers

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“…There is evidence in the literature that innate immune system mechanisms triggered by local tissue signals called S100 proteins play a role in the pathogenesis of many pediatric rheumatic diseases. 10,20 S100A12 proteins, which are recognized by innate immune system cells through TLR4 receptors, are thought to be used as a biomarker in auto-inflammatory diseases, since they cause inflammation. 20,21 Clarifying the pathways of interaction of S100A12 with TLR4 will provide a better understanding of its roles in the pathology of autoinflammatory diseases.…”

Section: Discussionmentioning

confidence: 99%

“…8 Serum neutrophil-derived S100A12 is part of the innate immunity and is associated with some autoimmune diseases like JIA and recent studies have also helped to show that S100A12 elevation is a sensitive and specific marker in localized inflammatory processes. [9][10][11] Moreover, serum S100A12 levels increase significantly during inflammatory attacks in patients with FMF and JIA. 12,13 Over the past decade, a wide variety of research has been conducted on receptors that mediate pro-inflammatory cytokine production in infection and tissue damage.…”

Section: Introductionmentioning

confidence: 98%

“…S100A12 is a small acidic protein and it is involved directly and indirectly in a few aspects, which trigger inflammatory factors in nuclear factor kappa B (NF‐κB) cell signaling 8 . Serum neutrophil‐derived S100A12 is part of the innate immunity and is associated with some autoimmune diseases like JIA and recent studies have also helped to show that S100A12 elevation is a sensitive and specific marker in localized inflammatory processes 9–11 . Moreover, serum S100A12 levels increase significantly during inflammatory attacks in patients with FMF and JIA 12,13 .…”

Section: Introductionmentioning

confidence: 99%

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The role of S100A12 and Toll‐like receptor 4 in assessment of disease activity in familial Mediterranean fever and juvenile idiopathic arthritis

et al. 2022

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Objective: Our aim was to investigate the possible relationship between the serum S100A12 and Toll-like receptor 4 (TLR4) levels, and the activity of familial Mediterranean fever (FMF) and juvenile idiopathic arthritis (JIA) in accordance with the routine biochemical parameters. Furthermore, the effectiveness of these 2 biomarkers in distinguishing FMF from JIA has been evaluated.Method: Sixty-nine children with FMF, 68 children with JIA, and 35 healthy children were included in this study. S100A12 and TLR4 levels were measured by the sandwich enzyme-linked immunosorbent assay technique. Results:In the FMF patient group, serum S100A12 level was found to be significantly higher than in both the JIA and control groups (P = .000 and P = .000, respectively).Although S100A12 levels were higher in the attack period compared to the attackfree period, this increase was not statistically significant (P > .05). TLR4 levels were statistically significantly higher in the attack period compared to the attack-free period in children with FMF (P < .05). Although there was no relationship between S100A12 levels and disease activity, there is a clear correlation between S100A12 and the Auto-Inflammatory Disease Activity Index in attack-free FMF patients (r = 0.612 P = .000). Conclusion:Serum S100A12 levels were not found to be a potentially valuable biomarker for assessing disease activity in either FMF or JIA. However, TLR4 levels were found to be a valuable biomarker for assessing disease activity in children with FMF.Further research which includes serial monitoring of S100A12 and TLR4 levels in a large cohort will provide detailed information about accuracy of these 2 potential biomarkers in both patients group.

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