S-transform time-frequency analysis of P300 reveals deficits in individuals diagnosed with alcoholism

Jones, Kevin; Porjesz, Bernice; Chorlian, David B.; Rangaswamy, Madhavi; Kamarajan, Chella; Padmanabhapillai, Ajayan; Stimus, Arthur T.; Begleiter, Henri

doi:10.1016/j.clinph.2006.02.028

Cited by 99 publications

(187 citation statements)

References 80 publications

Supporting

Mentioning

167

Contrasting

Unclassified

Order By: Relevance

“…Using go-nogo tasks several studies from our laboratory have shown P300, delta and theta power differences in alcoholics and high risk individuals (Kamarajan et al, 2004;Kamarajan et al, 2005a;Kamarajan et al, 2005b). In these studies the 'go' trials closely resemble the 'target' trial used in the present study.…”

Section: Discussionsupporting

confidence: 56%

“…The authors have reported robust P3 amplitude reductions in the parietal region of the alcoholic sample for the 'go" trials (Kamarajan et al, 2005b). In the Go condition, strong delta band total ERO deficits for alcoholics were observed over frontal, parietal and occipital locations; however, no theta band differences were noted in alcoholics when compared to the controls (Kamarajan et al, 2004). In the high-risk adult population the results for the same task revealed parietal delta and theta band total power reductions for the Go condition (Kamarajan et al, 2005a).…”

Section: Discussionmentioning

confidence: 98%

“…Previously published and ongoing studies from our group have examined theta and delta oscillations in adult populations (both alcohol dependent and high risk) for the standard visual oddball and go-nogo tasks (Jones et al, in preparation;Kamarajan et al, 2004;Kamarajan et al, 2005a;Kamarajan et al, 2005b). The results from those studies strongly support the present study that extends similar findings into HR adolescent population.…”

Section: Discussionmentioning

confidence: 99%

“…The responses to the Go condition in this task closely resemble the oddball target condition, although the stimuli used in the task are different. The topography of reduced theta power as reported for alcoholics involves a topographically frontal component (Jones et al, in preparation;(Kamarajan et al, 2004). It has been suggested by , that a diffuse and distributed theta system exists in the brain.…”

Section: Event-related Theta Band Changesmentioning

confidence: 93%

“…Karakas et al (2002a,b) consider P300 component to be composed of superimposed delta and theta oscillation. Kamarajan et al (2004)reported a study of oscillations in adult alcoholics in a Go-Nogo P3 paradigm. The responses to the Go condition (that closely resembles the oddball target condition) had reduced delta band power in the parietal occipital and frontal regions.…”

Section: Event-related Delta Band Changesmentioning

confidence: 99%

See 4 more Smart Citations

Delta and theta oscillations as risk markers in adolescent offspring of alcoholics

Rangaswamy

Jones

Porjesz

et al. 2007

International Journal of Psychophysiology

Self Cite

117

136

View full text Add to dashboard Cite

Background-Visual P300 is consistently lower in alcohol dependent individuals, their offspring and subjects at risk. Delta and theta event related oscillations (ERO) are the major contributors to the P300 signal. The total and evoked power in delta and theta bands in the 300 to 700 millisecond post-stimulus window (corresponding to the zone of P3 maxima) was compared between adolescent offspring of alcoholics (high-risk) and age-matched normal controls (low-risk), to assess the utility of the risk markers.Methods-EEG was recorded during the performance of visual oddball task. The S-Transform algorithm decomposed the EEG signals into different frequency bands and the group differences in total and evoked power in the oscillatory responses during the P300 time window (300 to 700 ms) were analyzed using a multivariate design. Similar analysis was performed on P300 peak amplitudes for the target.Results-The high-risk group showed significantly lower parietal post-stimulus evoked and total power in the delta band for targets. A decrease in total power was seen centrally and parietally in theta band. The P300 peak amplitude in the parietal electrodes was also significantly lower in the high-risk group.Conclusions-The decreased total theta power and total and evoked delta power for visual targets in high risk individuals may serve as an endophenotypic marker in the development of alcoholism and other disinhibitory disorders. The differences seen between the offspring of alcoholics and controls may have a cholinergic basis. The ERO measures appear to be more robust than the P300 amplitude in differentiating the groups.

show abstract

Section: Discussionsupporting

confidence: 56%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Event-related Theta Band Changesmentioning

confidence: 93%

Section: Event-related Delta Band Changesmentioning

confidence: 99%

See 3 more Smart Citations

Delta and theta oscillations as risk markers in adolescent offspring of alcoholics

Rangaswamy

Jones

Porjesz

et al. 2007

International Journal of Psychophysiology

Self Cite

117

136

View full text Add to dashboard Cite

show abstract

Genome‐wide association study of theta band event‐related oscillations identifies serotonin receptor gene HTR7 influencing risk of alcohol dependence

Zlojutro

Manz

Rangaswamy

et al. 2010

American J of Med Genetics Pt B

Self Cite

View full text Add to dashboard Cite

Event-related brain oscillations (EROs) represent highly heritable neuroelectrical correlates of human perception and cognitive performance that exhibit marked deficits in patients with various psychiatric disorders. We report the results of the first genome-wide association study (GWAS) of an ERO endophenotype – frontal theta ERO evoked by visual oddball targets during P300 response in 1,064 unrelated individuals drawn from a study of alcohol dependence. Forty-two SNPs of the Illumina HumanHap 1M microarray were selected from the theta ERO GWAS for replication in family-based samples (N = 1,095), with four markers revealing nominally significant association. The most significant marker from the two-stage study is rs4907240 located within ARID protein 5A gene (ARID5A) on chromosome 2q11 (unadjusted, Fisher’s combined P = 3.68 × 10−6). However, the most intriguing association to emerge is with rs7916403 in serotonin receptor gene HTR7 on chromosome 10q23 (combined P = 1.53 × 10−4), implicating the serotonergic system in the neurophysiological underpinnings of theta EROs. Moreover, promising SNPs were tested for association with diagnoses of alcohol dependence (DSM-IV), revealing a significant relationship with the HTR7 polymorphism among GWAS case-controls (P = 0.008). Significant recessive genetic effects were also detected for alcohol dependence in both case-control and family-based samples (P = 0.031 and 0.042, respectively), with the HTR7 risk allele corresponding to theta ERO reductions among homozygotes. These results suggest a role of the serotonergic system in the biological basis of alcohol dependence and underscore the utility of analyzing brain oscillations as a powerful approach to understanding complex genetic psychiatric disorders.

show abstract

Theta event‐related synchronization is a biomarker for a morbid effect of alcoholism on the brain that may partially resolve with extended abstinence

Gilmore

Fein

2012

Brain and Behavior

View full text Add to dashboard Cite

Analyzing the induced (non-stimulus-phase-locked) EEG activity elicited by targets in a three-condition visual oddball task, Fein and colleagues have shown increased theta band event-related synchronization (ERS) in two different samples of long-term abstinent alcoholics (LTAA) compared with age- and gender-comparable controls. The theta ERS effect in alcoholics was also shown to be independent of, and opposite in direction to, the reduced amplitude evoked (stimulus-phase-locked) activity typically found in alcoholics and those at genetic risk of developing alcoholism. This study extends these findings by applying time-frequency analysis to target stimulus event-related EEG to compare evoked and induced theta activity in 43 LTAA and 72 nonalcoholic controls with a group of 31 alcoholics who just recently initiated abstinence from alcohol (between 6- and 15-week abstinent; referred to as short-term abstinent alcoholics, STAA). Results demonstrated that (1) evoked theta power was reduced to the same degree in STAA and LTAA compared with nonalcoholic control participants, while (2) induced theta activity, measured by theta ERS, was increased in both STAA and LTAA relative to controls, but was also increased in STAA relative to LTAA. The STAA and LTAA groups did not differ on measures of alcohol use severity or family history of alcohol problems. These results, coupled with previous findings that show a relationship between stronger theta ERS and increased memory load and attention allocation, suggest that increased theta ERS may be a biomarker for a detrimental effect of chronic alcohol abuse on the brain – a detriment that may recover, at least partially, with extended abstinence.

show abstract

S-transform time-frequency analysis of P300 reveals deficits in individuals diagnosed with alcoholism

Cited by 99 publications

References 80 publications

Delta and theta oscillations as risk markers in adolescent offspring of alcoholics

Delta and theta oscillations as risk markers in adolescent offspring of alcoholics

Genome‐wide association study of theta band event‐related oscillations identifies serotonin receptor gene HTR7 influencing risk of alcohol dependence

Theta event‐related synchronization is a biomarker for a morbid effect of alcoholism on the brain that may partially resolve with extended abstinence

Contact Info

Product

Resources

About