S, N-doped carbon quantum dots enhanced Luminol-Mn(IV) chemiluminescence reaction for detection of uric acid in biological fluids

Hallaj, Tooba; Amjadi, Mohammad; Mirbirang, Fatemeh

doi:10.1016/j.microc.2020.104841

Cited by 25 publications

(7 citation statements)

References 44 publications

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“…The surface chemical composition and element status of N-CQDs were investigated further utilizing X-ray photoelectron spectroscopy (XPS). The XPS spectrum of N-CQD in Figure 2a shows three peaks at 532.3 eV, 286 eV and 400.4 eV, corresponding to O1s, C1s and N1s, respectively [26,44,45], indicating that N-CQDs are mostly constituted of carbon, nitrogen, and oxygen. The high resolution XPS spectrum of C1s in Figure 2b shows five peaks at 284.6 eV, 285.5 eV, 286.4 eV, 287.1 eV and 288.3 eV that may be traced to C=C, C-C, C-N, C-O and C=O bonding on the surface of N-CQDs [26,46].…”

Section: The Morphology and Surface Composition Of N-cqdsmentioning

confidence: 99%

Synthesis and Properties of Nitrogen-Doped Carbon Quantum Dots Using Lactic Acid as Carbon Source

Chang

Zhu

et al. 2022

Materials

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Nitrogen-doped carbon quantum dots (N-CQDs) were synthesized in a one-step hydrothermal technique utilizing L-lactic acid as that of the source of carbon and ethylenediamine as that of the source of nitrogen, and were characterized using dynamic light scattering, X-ray photoelectron spectroscopy ultraviolet-visible spectrum, Fourier-transformed infrared spectrum, high-resolution transmission electron microscopy, and fluorescence spectrum. The generated N-CQDs have a spherical structure and overall diameters ranging from 1–4 nm, and their surface comprises specific functional groups such as amino, carboxyl, and hydroxyl, resulting in greater water solubility and fluorescence. The quantum yield of N-CQDs (being 46%) is significantly higher than that of the CQDs synthesized from other biomass in literatures. Its fluorescence intensity is dependent on the excitation wavelength, and N-CQDs release blue light at 365 nm under ultraviolet light. The pH values may impact the protonation of N-CQDs surface functional groups and lead to significant fluorescence quenching of N-CQDs. Therefore, the fluorescence intensity of N-CQDs is the highest at pH 7.0, but it decreases with pH as pH values being either more than or less than pH 7.0. The N-CQDs exhibit high sensitivity to Fe3+ ions, for Fe3+ ions would decrease the fluorescence intensity of N-CQDs by 99.6%, and the influence of Fe3+ ions on N-CQDs fluorescence quenching is slightly affected by other metal ions. Moreover, the fluorescence quenching efficiency of Fe3+ ions displays an obvious linear relationship to Fe3+ concentrations in a wide range of concentrations (up to 200 µM) and with a detection limit of 1.89 µM. Therefore, the generated N-CQDs may be utilized as a robust fluorescence sensor for detecting pH and Fe3+ ions.

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Section: The Morphology and Surface Composition Of N-cqdsmentioning

confidence: 99%

Synthesis and Properties of Nitrogen-Doped Carbon Quantum Dots Using Lactic Acid as Carbon Source

Chang

Zhu

et al. 2022

Materials

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“…Although AA and Cys are often used to scavenge free radicals, 44−46 the concentration of AA and Cys in normal human serum is usually much lower than that of UA. 20,47,48 This study demonstrates that our method is possible for UA detection in human serum samples.…”

Section: Reaction and Mechanism Of Luminol With Feooh Nanorodsmentioning

confidence: 59%

Enhanced Luminol Chemiluminescence with Oxidase-like Properties of FeOOH Nanorods for the Sensitive Detection of Uric Acid

Xia

Sang

et al. 2023

Anal. Chem.

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FeOOH nanorods, as one-dimensional nanomaterials, have been widely used in many fields due to their stable properties, low cost, and easy synthesis, but their application in the field of chemiluminescence (CL) is rarely reported. In this work, FeOOH nanorods were synthesized by a simple and environmentally friendly one-pot hydrothermal method and used for the first time as a catalyst for generating strong CL with luminol without additional oxidant. Remarkably, luminol-FeOOH exhibits about 250 times stronger CL than the luminol-H 2 O 2 system. Its CL intensity was significantly quenched by uric acid. We established a simple, rapid, sensitive, and selective CL method for the detection of uric acid with a linear range of 20−1000 nM and a detection limit of 6.3 nM (S/N = 3). In addition, we successfully applied this method to the detection of uric acid in human serum, and the standard recoveries were 95.6−106.4%.

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“…In general, photoluminescent CDs can be prepared by using N, S, or other heteroatom-containing organic compounds as reactants (Jiang et al, 2014;Chang et al, 2016;Deng et al, 2018;Hou et al, 2018;Meng et al, 2018;Prekodravac et al, 2019;Wu and Tong, 2019;Yao et al, 2019;Zheng et al, 2019;Hallaj et al, 2020;Ji et al, 2021). Natural amino acids containing N, O, or S heteroatoms, as building blocks of proteins, can show some favorable merits, such as being biocompatible, plentiful, and low cost, which makes them ideal precursors for synthesizing CDs.…”

Section: Introductionmentioning

confidence: 99%

A Multi-Catalytic Sensing for Hydrogen Peroxide, Glucose, and Organophosphorus Pesticides Based on Carbon Dots

Sun

Shen

2021

Front. Chem.

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In this work, a facile one-pot hydrothermal route was employed to synthesize a series of fluorescent carbon dots (CDs) by using 20 natural amino acids, respectively, as the starting materials. It was found that the CDs synthesized using phenylalanine could possess the intrinsic peroxidase-like activity that could effectively catalyze a traditional peroxidase substrate like 3, 3’, 5, 5’- tetramethylbenzidine (TMB) in the presence of H2O2 to produce a blue solution; thereby, a catalytic sensing system for H2O2 has been developed. On the basis of this catalytic reaction, together with the fact that glucose oxidase (GOx) can catalyze the hydrolysis of glucose to generate H2O2, a sensitive catalytic sensing system for glucose could be further established. Furthermore, based on this catalytic reaction, taken together with the two enzymatic catalytic systems of acetylcholinesterase (AChE) and choline oxidase (CHO), a highly sensitive multi-catalytic sensing system could be successfully developed for organophosphorus (OPs) pesticides such as dimethoate, DDVP, and parathion-methyl. Limit of detections (LODs) of H2O2 and glucose were estimated to be 6.5 and 0.84 μM, respectively. The limit of detection of the sub-nM level could be obtained for tested dimethoate, DDVP, and parathion-methyl OPs pesticides. The established sensing systems can exhibit good practical application performance in serum and several fruit samples.

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S, N-doped carbon quantum dots enhanced Luminol-Mn(IV) chemiluminescence reaction for detection of uric acid in biological fluids

Cited by 25 publications

References 44 publications

Synthesis and Properties of Nitrogen-Doped Carbon Quantum Dots Using Lactic Acid as Carbon Source

Synthesis and Properties of Nitrogen-Doped Carbon Quantum Dots Using Lactic Acid as Carbon Source

Enhanced Luminol Chemiluminescence with Oxidase-like Properties of FeOOH Nanorods for the Sensitive Detection of Uric Acid

A Multi-Catalytic Sensing for Hydrogen Peroxide, Glucose, and Organophosphorus Pesticides Based on Carbon Dots

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