2018
DOI: 10.1007/s00508-017-1299-3
|View full text |Cite|
|
Sign up to set email alerts
|

S(+)-ketamine

Abstract: SummaryS(+)-ketamine, the pure dextrorotatory enantiomer of ketamine has been available for clinical use in analgesia and anesthesia for more than 25 years. The main effects are mediated by non-competitive inhibition of the N-methyl-D-aspartate (NMDA) receptor but S(+)-ketamine also interacts with opioid receptors, monoamine receptors, adenosine receptors and other purinergic receptors. Effects on α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, metabotropic glutamate receptors (mGluR) an… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1

Citation Types

2
41
0
1

Year Published

2020
2020
2023
2023

Publication Types

Select...
5
1
1
1

Relationship

0
8

Authors

Journals

citations
Cited by 75 publications
(46 citation statements)
references
References 68 publications
(96 reference statements)
2
41
0
1
Order By: Relevance
“…The main effects of S-ketamine are mediated by non-competitive inhibition of the N-methyl-D-aspartate receptor; the compound also interacts with opioid receptors, monoamine receptors, and adenosine receptors. 22 It is associated with dissociation (ability to communicate with the patient is retained to a certain degree), quick onset, absence of breathing function depression, and circulatory stability in shock patients, making it popular among emergency and intensive care medicine practitioners. 22 In addition, it is relatively safe for infants and children, 13 making S-ketamine a suitable candidate for an adjuvant IV drug during cesarean delivery with spinal anesthesia.…”
Section: Discussionmentioning
confidence: 99%
See 2 more Smart Citations
“…The main effects of S-ketamine are mediated by non-competitive inhibition of the N-methyl-D-aspartate receptor; the compound also interacts with opioid receptors, monoamine receptors, and adenosine receptors. 22 It is associated with dissociation (ability to communicate with the patient is retained to a certain degree), quick onset, absence of breathing function depression, and circulatory stability in shock patients, making it popular among emergency and intensive care medicine practitioners. 22 In addition, it is relatively safe for infants and children, 13 making S-ketamine a suitable candidate for an adjuvant IV drug during cesarean delivery with spinal anesthesia.…”
Section: Discussionmentioning
confidence: 99%
“…22 It is associated with dissociation (ability to communicate with the patient is retained to a certain degree), quick onset, absence of breathing function depression, and circulatory stability in shock patients, making it popular among emergency and intensive care medicine practitioners. 22 In addition, it is relatively safe for infants and children, 13 making S-ketamine a suitable candidate for an adjuvant IV drug during cesarean delivery with spinal anesthesia. The present study ndings suggest that an ultra-low single IV bolus dose of S-ketamine may induce sleep, decrease visceral traction pain from surgical interventions, and eliminate tension in patients that undergo cesarean delivery without increasing the risk of adverse events.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Many patients have their eyes open, exhibit spontaneous movements, and retain functional reflexes. Tears and saliva may also flow but the patient does not remember the operation or the anesthesia [66]. The emergence from anesthesia itself may be associated with unpleasant dreams and hallucinations.…”
Section: Consciousness As a Quantum Information-theoretic Statementioning
confidence: 99%
“…S-KET is an isomer of KET with superior efficacy and controllability, and fewer side effects as compared to a racemic mixture of R-KET and S-KET (Kose et al, 2012;Paul et al, 2009;Trimmel et al, 2018). In recent years, S-KET has been widely used in Europe and the United States for the treatment for mental health disorders (Wilkinson et al, 2018;Bartlett et al, 2020;Grunebaum et al, 2018;Murrough et al, 2015), post-traumatic stress disorder, and related syndromes, while racemic ketamine is still widely used in China (Chang et al, 2019;Aleksandrova et al, 2017;Zanos and Gould, 2018;du Jardin et al, 2016).…”
mentioning
confidence: 99%