S-(DICHLOROVINYL)-L-CYSTEINE: AN AGENT CAUSING FATAL APLASTIC ANEMIA IN CALVES<sup>1</sup>

McKinney, L. L.; Weakley, F. B.; Eldridge, A. C.; Campbell, Robert E.; Cowan, J. C.; Picken, J. C.; Biester, H. E.

doi:10.1021/ja01571a093

Cited by 71 publications

(13 citation statements)

References 2 publications

(4 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several 6-(substituted)-purities have been found to possess activity in many different biological systems; for example, they promote cell division in tobacco callus tissue,1 inhibit hydra tentacle regeneration,2 increase the rate of lettuce seed germination,3•4 stimulate moss bud formation,6 augment the growth inhibition of 2,4-diamino-6,7diphenylpteridine upon Lactobacillus arabinosus, 6 and recently have been observed to act synergistically with gibberellin in promoting seed germination.7 While the group substituted in the 6-position may be modified considerably with retention of biological activity, other changes in the purine nucleus have resulted in compounds which are inactive in most of these test systems. 8 In the present investigation, a number of the more effective 6-(substituted)-purine analogs were modified by introducing an amino group in the 2position.…”

mentioning

confidence: 99%

Synthesis and Biological Activity of Some 2-Amino-6-(substituted)-purines

Leonard¹,

Skinner²,

Lansford³

et al. 1959

J. Am. Chem. Soc.

View full text Add to dashboard Cite

Five new 2-amino-6-(substituted)-aminopurines were prepared by a thermal condensation of 2-amino-6-methylthiopurine and the appropriate amine, and all were found to augment the growth inhibition of 2,4-diamino-6,7-diphenylpteridine upon Lactobacillus arabinosus. Some of the diaminopurine derivatives stimulated the rate of lettuce seed germination; however, they were somewhat less active than the corresponding 6-(substituted)-aminopurines.

show abstract

mentioning

confidence: 99%

Synthesis and Biological Activity of Some 2-Amino-6-(substituted)-purines

Leonard¹,

Skinner²,

Lansford³

et al. 1959

J. Am. Chem. Soc.

View full text Add to dashboard Cite

show abstract

“…Mice were mated overnight; the 19th day from start of pregnancy (obser-vation of vaginal plug=day 0) coincided with the first day after birth (approximately 6-12 hr post partum). (I4C-DCVC) and unlabelled DCVC were synthesized according to McKinney et al (1957) and purified on HPLC (Lichrosorb C,,, 3.8 x 300 mm; methanol-water 3:7 by vol. ; 1 ml/min.…”

Section: Methodsmentioning

confidence: 99%

Age‐ and Sex‐Dependent Dichlorovinyl Cysteine (DCVC) Accumulation and Toxicity in the Mouse Kidney: Relation to Development of Organic Anion Transport and β‐Lyase Activity

Darnerud

Gustafson

Törnwall

et al. 1991

Pharmacology & Toxicology

View full text Add to dashboard Cite

The age- and sex-dependent changes in mouse kidney accumulation and toxicity of S-1,2-dichlorovinyl cysteine (DCVC) was investigated. The results were compared to developmental changes in the basal activities of organic anion transport in vitro (PAH uptake) and of cysteine conjugate beta-lyase (substrate: benzothiazolyl cysteine). Following 14C-DCVC (5 mg/kg body wt. orally), the renal 14C-accumulation increased with age, whereas the degree of tubular DCVC lesions was about the same at all time points. Regarding the sex differentiation in adult mice, both the kidney 14C-accumulation levels and the kidney lesion (5 mg/kg DCVC) were most accentuated in the female mouse. However, at a higher dose (25 mg/kg), the male kidney was most affected. Changes in the anion transport and beta-lyase activities did not directly mirror the age-dependent increase in kidney radioactivity. Sex differences in anion transport and beta-lyase activities were also seen, the former activity being highest in the male mouse and the latter in the female. The conflicting results of 14C-accumulation and histopathology in developing mice, may be explained by the ongoing development of the kidney; increase in the number of functionally active nephrons may result in an increased 14C-accumulation (in d.p.m./mg wet wt.) but still the same degree of lesion, when estimated per nephron. In the adult mice, the higher susceptibility of the female may be correlated to the higher beta-lyase activity in the same sex. Regarding the inversed results at a higher dose, rate limitations of transport and bioactivation systems may play a role.

show abstract

“…of concentrate from 10.8 kg. of fraction I; yield of nitrogen, 64.9%; nitrogen content, 11.5%; total solids, 50.5%; and ash, 12.4%. Ratio of total nitrogen to amino nitrogen wras 3.59 to 1. Fractions N-l and N-2.…”

Section: Preparation Of Fractionsmentioning

confidence: 98%