S(+) cetamina em baixas doses: atualização

Abstract

Most studies with low S(+) ketamine doses have shown preventive effects, decreasing central nervous system sensitization, opioid-induced tolerance and hyperalgesia, anesthetic and analgesic consumption, and the incidence of postoperative adverse effects.

Eficácia analgésica do uso da dextrocetamina intra-articular em pacientes submetidos a artroplastia total do joelho

“…It is known that the commonly used doses (5 mg.kg -1 -intramuscularly or 1-2 mg.kg -1 intravenously) are not ideal, as dysleptic phenomena often occur in patients. The benefits of S(+)-ketamine exist when it is used in small doses (0.1 to 0.25 mg.kg-1 ) via parenteral route, due to its greater affinity for the NMDA receptors, which provides adequate analgesia and consumption reduction of analgesics postoperatively 12,41 . In our study, the lowest dose of S(+)-ketamine (Group A: 0.25 mg.kg -1 ) showed the best trend toward reducing pain scores and also demonstrated the possibility of ketamine better effects at lower doses via intraarticular route.…”

“…Due to its significant adverse effects, ketamine has not gained wide clinical acceptance. Dextro salt of ketamine, isomer S(+) ketamine, was recently released, which has similar properties to the racemic form, greater analgesic potency, and fewer side effects, arousing a renewed interest in this drug 12 .…”