S-adenosylmethionine stimulates fatty acid metabolism-linked gene expression in porcine muscle satellite cells

Tao, Yue; Qian, Fang; Yin, Jingdong; Li, Defa; Li, Wei

doi:10.1007/s11033-009-9893-8

Cited by 10 publications

(5 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, many genes and microRNAs were found to be involved in growth-related or lipid metabolism-related processes in other studies. For example, Zhang et al proved that myogenic regulatory factors (MRFs) were critical for successful myogenesis [ 8 ], and Yue et al demonstrated that adipocyte determination and differentiation factor-1 (ADD1) expression was related to adipocyte differentiation in pigs [ 9 ]. Besides, Feng et al found that microRNA-214 can influence skeletal muscle development by regulating embryonic myogenesis [ 10 ], and Li et al revealed that microRNA-103 had an impact on porcine preadipocyte differentiation through the putative target gene RAI14 [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Transcriptome Analysis Reveals Long Intergenic Noncoding RNAs Contributed to Growth and Meat Quality Differences between Yorkshire and Wannanhua Pig

Zou,

Li,

Deng

et al. 2017

Genes

View full text Add to dashboard Cite

There are major differences between Yorkshire (lean-type) and Wannanhua pig (fat-type) in terms of growth performance and meat quality. Long intergenic noncoding RNAs (lincRNAs) are a class of regulators that are involved in numerous biological processes and widely identified in many species. However, the role of lincRNAs in pig is largely unknown, and the mechanisms by which they affect growth and meat quality are elusive. In this study, we used published data to identify 759 lincRNAs in porcine longissimus dorsi muscle. These putative lincRNAs shared many features with mammalian lincRNAs, such as shorter length and fewer exons. Gene ontology and pathway analysis indicated that many potential target genes (PTGs) of lincRNAs were involved in muscle growth-related and meat quality-related biological processes. Moreover, we constructed a co-expression network between differentially expressed lincRNAs (DELs) and their PTGs, and found a potential mechanism that most DELs can use to upregulate their PTGs, which may finally contribute to the growth and meat quality differences between the two breeds through an unknown manner. This work details some lincRNAs and their PTGs related to muscle growth or meat quality, and facilitates future research on the roles of lincRNAs in these two types of pig, as well as molecular-assisted breeding for pig.

show abstract

Section: Introductionmentioning

confidence: 99%

Transcriptome Analysis Reveals Long Intergenic Noncoding RNAs Contributed to Growth and Meat Quality Differences between Yorkshire and Wannanhua Pig

Zou,

Li,

Deng

et al. 2017

Genes

View full text Add to dashboard Cite

show abstract

“…There are several coding genes associated with meat quality, for example adipocyte determination and differentiation dependent factor 1 (ADD1), which stimulates PPARgama expression and promotes adipogenic differentiation [48], whose expressional level is associated with IMF content (P < 0.05) [49]. The stearoyl-CoA desaturase (SCD) gene participates in fatty acids desaturation and oleic fatty acid synthesis, and SCD overexpression in muscle is correlated with a higher IMF content [50].…”

Section: Discussionmentioning

confidence: 99%

LncRNA IMFlnc1 Promotes Porcine Intramuscular Adipocyte Adipogenesis by Sponging Mir-199a-5p to Up-regulate CAV-1

Wang

Chen

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Local Chinese local pig breeds have thinner muscle fiber and higher intramuscular-fat (IMF) content. But its regulation mechanism has not been discussed in-depth. Studies indicated that long non coding RNAs (lncRNAs) play important role in muscle and fat development.Results: The lncRNAs expressional differences in the longissimus dorsi (LD) muscle were identified between Huainan pigs (local Chinese pigs, fat-type, HN) and Large White pigs (lean-type, LW) at 38, 58, and 78 days post conception (dpc). In total, 2131 novel lncRNAs were identified in 18 samples, and 291, 305, and 683 differentially expressed lncRNAs (DELs) were found between these two breeds at three stages, respectively. GO and KEGG analysis of the DEL co expressed mRNAs showed that muscle development and energy metabolism were more active at 58 dpc in HN, but at 78 dpc in LW pigs. Muscle cell differentiation and myofibril assembly might associated with earlier myogenesis and primary-muscle-fiber assembly in HN, and cell proliferation, insulin, and the MAPK pathway might contribute to longer proliferation in LW pigs. The PI3K/Akt and cAMP pathways were associated with higher IMF deposition in HN. IMFlnc1 was selected for functional verification, and results indicated that it regulated the expressional level of caveolin-1 (CAV-1) by acting as competing endogenous RNA (ceRNA) to sponge miR-199a-5p.Conclusions: Our data contributed to understanding lncRNAs in porcine-muscle development and IMF deposition, and provided valuable information for improving pig-meat quality.

show abstract

“…There are several coding genes associated with meat quality, such as adipocyte determination and differentiation dependent factor 1 (ADD1), which stimulates PPARgama expression and plays an important role in adipogenic differentiation [63], whose expressional level is positively correlated with IMF content (P < 0.05) [64], The stearoyl-CoA desaturase (SCD) gene plays a key role in the desaturation of fatty acids and synthesis of oleic fatty acid, and SCD overexpression in muscle is correlated with a higher IMF content [65]. SCD showed a signi cantly different expressional level in LD muscle between LT and LR pigs [66].…”

Section: Discussionmentioning

confidence: 99%

LncRNA IMFlnc1 promotes porcine intramuscular adipocyte differentiation by sponging miR-199a-5p to up-regulate CAV-1

Wang

Chen

et al. 2020

Preprint

View full text Add to dashboard Cite

Background Local Chinese local pig breeds have better meat quality, such as thinner muscle fiber and higher intramuscular-fat (IMF) content. However, its molecular regulation mechanism has not been discussed in-depth. Studies indicated that long non coding RNAs (lncRNAs) participate in the regulation of muscle and fat development. The expressional differences of lncRNAs in the longissimus dorsi (LD) muscle were identified between Huainan pigs (local Chinese pigs, fat-type, HN) and Large White pigs (lean-type, LW) at 38, 58, and 78 days post conception (dpc).Results In total, 2131 novel lncRNAs were identified in 18 samples, and 291, 305, and 683 differentially expressed lncRNAs (DELs) were found between these two breeds at three stages, respectively. GO and KEGG analysis of the DEL co expressed mRNAs showed that muscle development and energy metabolism were more active at 58 dpc in HN, but at 78 dpc in LW pigs. Muscle cell differentiation and myofibril assembly might contribute to earlier myogenesis and primary-muscle-fiber assembly in HN, and cell proliferation, insulin, and the mitogen-activated protein kinase (MAPK) pathway might contribute to longer proliferation in LW pigs. The PI3K/Akt and cAMP pathways were associated with higher IMF deposition in HN. IMFlnc1 was selected for functional verification, and results indicated that it regulated the expressional level of caveolin-1 (CAV-1) as a competing endogenous RNA (ceRNA) for miR-199a-5p.Conclusion Our data contributed to understanding lncRNAs in porcine-muscle development and IMF deposition, and provided valuable information for improving pig-meat quality.

show abstract

S-adenosylmethionine stimulates fatty acid metabolism-linked gene expression in porcine muscle satellite cells

Cited by 10 publications

References 27 publications

Transcriptome Analysis Reveals Long Intergenic Noncoding RNAs Contributed to Growth and Meat Quality Differences between Yorkshire and Wannanhua Pig

Transcriptome Analysis Reveals Long Intergenic Noncoding RNAs Contributed to Growth and Meat Quality Differences between Yorkshire and Wannanhua Pig

LncRNA IMFlnc1 Promotes Porcine Intramuscular Adipocyte Adipogenesis by Sponging Mir-199a-5p to Up-regulate CAV-1

LncRNA IMFlnc1 promotes porcine intramuscular adipocyte differentiation by sponging miR-199a-5p to up-regulate CAV-1

Contact Info

Product

Resources

About