S-100-Negative malignant pulmonary granular cell tumor: A case report

Kim, Bo‐Guen; Song, Ju Yeun; Zo, Sungmin; Im, Yunjoo; Choi, Sangjoon; Han, Joungho; Jeong, Byeong‐Ho; Kim, Hojoong

doi:10.1016/j.rmcr.2020.101002

Cited by 4 publications

(4 citation statements)

References 19 publications

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“…Despite being relatively rare compared to other neoplastic processes, granular cell tumors (GCTs) exhibit various localizations, including atypical forms. For example, two cases of pulmonary NNGCTs have been reported in the literature [3,10]. A single case of a NGCT occurring in the uterine body of a fifty-five-year-old premenopausal patient has been documented in the literature [6].…”

Section: Discussionmentioning

confidence: 99%

“…While the tumor primarily affects the skin of the limbs and back, occurrences have also been reported on the face and scalp. Interestingly, the most common non-cutaneous location is the oral cavity [3][4][5][6]. Due to the wide range of possible differential diagnoses, the final diagnosis of non-neural granular cell tumors typically requires a thorough histological and immunohistochemical examination [6].…”

Section: Introductionmentioning

confidence: 99%

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Unique Case of Rare Non-Neural Granular Cell Tumor of the Rectus Abdominis Muscle

Kiskinov,

Palavurov,

Mollova-Kyosebekirova

et al. 2024

Medicina

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Background and Objectives: Our report contributes a unique case of a non-neural GCT occurring in an unusual location, with its development during pregnancy adding to its rarity. Materials and Methods: Granular cell tumors (GCTs), also known as Abrikossoff’s tumors, are rare neoplasms of Schwann cell origin with predominantly benign behavior. We present a case of a 29-year-old female with a non-neural variant of a GCT discovered incidentally during a cesarean section, situated on the posterior surface of the rectus abdominis muscle. Results: Histologically, the tumor exhibited features consistent with a benign non-neural GCT, confirmed through an immunohistochemical analysis. Despite the atypical presentation and challenging surgical removal due to prior scarring, the patient experienced no postoperative complications and showed no signs of recurrence during follow-up. Conclusions: This case highlights the importance of considering GCTs in differential diagnoses, particularly in unusual anatomical locations, and underscores the favorable prognosis associated with timely surgical intervention.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Unique Case of Rare Non-Neural Granular Cell Tumor of the Rectus Abdominis Muscle

Kiskinov,

Palavurov,

Mollova-Kyosebekirova

et al. 2024

Medicina

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“…10 Meanwhile, metastatic lesions often occur in lung organs other than regional lymph nodes. 22 Granular cell tumors can also spread to organs such as the liver, bones, and breasts. 12 90% of lung granular cell tumors cases are endobronchial masses.…”

Section: Discussionmentioning

confidence: 99%

“…Biopsy via bronchoscopy is one of the main options for diagnosis in cases involving the lungs. 22 Findings of tumors in the lungs are often detected incidentally. A chest X-ray or computed tomography (CT) scan is usually the initial suspicion of a mass.…”

Section: Discussionmentioning

confidence: 99%

Is Docetaxel the Main Therapy for Lung Metastasis in Granular Cell Tumors?

Pramono

Setijadi

Sutanto

et al. 2023

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Introduction: A granular cell tumor is a rare neoplasm originating from mesenchymal tissue. Malignant granular cell tumors have a poor prognosis. The lung is one of the target organs for metastatic malignant granular cell tumors. The number of rare cases makes managing metastatic malignant granular cell tumors unknown. Case: A 19-year-old male complained of shortness of breath for two months. A liver nodule biopsy revealed poorly differentiated carcinoma metastases. Histopathology of the left manus and frontal masses found granular cell tumors—negative immunohistochemistry on S-100 and myogenin. Ki-67 obtained a value of 5%. An X-ray and contrast multislice computerized tomography (MSCT) scan showed multiple metastatic nodules. Right bronchial biopsy forceps revealed a metastatic granular cell tumor. The patient was given docetaxel for six cycles. During the post-administration of docetaxel, the patient experienced clinical and radiological improvement. Conclusion: Until 2016, only three case reports of S-100 negative granular cell tumors existed. A negative S-100 test does not rule out the diagnosis of granular cell tumors. Malignant lesions are more common in males, as in this case. The number of rare cases means that management cannot be determined. Reports of similar cases show patients surviving up to 11 years with docetaxel administration. The patient in this study has survived for one year and is complaint-free.

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Primitive non-neural granular cell tumor: Literature review

Qasem

2022

Human Pathology Reports

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S-100-Negative malignant pulmonary granular cell tumor: A case report

Cited by 4 publications

References 19 publications

Unique Case of Rare Non-Neural Granular Cell Tumor of the Rectus Abdominis Muscle

Unique Case of Rare Non-Neural Granular Cell Tumor of the Rectus Abdominis Muscle

Is Docetaxel the Main Therapy for Lung Metastasis in Granular Cell Tumors?

Primitive non-neural granular cell tumor: Literature review

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