Primitive non-neural granular cell tumor: Literature review

Di, Jing; Qasem, Shadi

doi:10.1016/j.hpr.2022.300652

Cited by 4 publications

(5 citation statements)

References 33 publications

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“…In Table 2, some neoplasms with granular cell differentiation are summarized, along with the main antibodies for differential diagnosis. 17,18 In our case, the patient presented with an erythematous-tobrownish firm nodule and should be differentiated from dermatofibroma in priority. Clinically, it showed a relatively large size with rapid NNGCT is generally considered to be of low to intermediate malignant potential.…”

Section: Discussionmentioning

confidence: 78%

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Dermatofibroma‐like dermal non‐neural granular cell tumor

et al. 2022

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Non‐neural granular cell tumor (NNGCT) is a rare tumor with uncertain lineage. It presents as an asymptomatic polypoid or plaque‐like lesion, especially on trunk. Because the granular cells are usually strongly reactive with S‐100 stain, conventional granular cell tumors (GCTs) are regarded as those of neural or Schwann cell origin. Unlike GCTs, NNGCT is not reactive for S‐100 protein and is thought to derive elsewhere, presumably from mesenchymal stem cells. A 20‐year‐old woman presented with a solitary, dermatofibroma‐like, brownish nodule on her right arm. The lesion developed 3 months before presentation without subjective symptoms. Histopathologic examination revealed a grenz zone overlying a poorly circumscribed tumor extending through the reticular dermis. The tumor cells were large and polygonal, and they had numerous eosinophilic small granules in the cytoplasm. Immunohistochemical stains were positive for CD68, vimentin, factor XIIIa, CD10, and cyclin D1. Stains for S‐100 protein, neuron‐specific enolase, and CD34 were negative. Based on these findings, the lesion was diagnosed as dermal NNGCT.

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Section: Discussionmentioning

confidence: 78%

“…ALK‐protein positivity in immunostaining could provide additional diagnostic support for NNGCT. In Table 2, some neoplasms with granular cell differentiation are summarized, along with the main antibodies for differential diagnosis 17,18 …”

Section: Discussionmentioning

confidence: 99%

Dermatofibroma‐like dermal non‐neural granular cell tumor

et al. 2022

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“…As compared to classic GCT, NNGCT are immunohistochemically distinct lacking expression of markers of neural differentiation like SOX10 and S100. Recent studies have shown ALK gene fusion in these types of tumors by FISH or IHC [2,3]. We report 2 cases of S100 and SOX10 negative granular cell tumor, both in paediatric patients.…”

Section: Introductionmentioning

confidence: 70%

ALK Positive Non-Neural Granular Cell Tumour in Two Paediatric Patients- A Case Report

Ramchandran

2023

CTOIJ

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Non-neural granular cell tumour (PNNGCT) is a rare mesenchymal neoplasm of unknown lineage with prominent cytoplasmic granularity [1]. These tumors are more common in children and young adults, and commonly involve the back and extremities. A panel of immunostains is important to rule out other differential diagnoses. In contrast to conventional granular cell tumor (GCT), NNGCT lacks S100 expression, hence, NKI-C3 and anaplastic lymphoma kinase (ALK) stains can be particularly helpful in confirming the diagnosis. In addition, an underlying ALK gene rearrangement has been reported in a small subset of cases [2]. In general, most of these tumors appear to behave in a benign fashion, and conservative management is recommended. Our results demonstrate that NNGCT harbour ALK fusions, which suggests that NNGCT are molecularly diverse, and further substantiate NNGCT as distinct from GCT [3].

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“…While the tumor primarily affects the skin of the limbs and back, occurrences have also been reported on the face and scalp. Interestingly, the most common non-cutaneous location is the oral cavity [3][4][5][6]. Due to the wide range of possible differential diagnoses, the final diagnosis of non-neural granular cell tumors typically requires a thorough histological and immunohistochemical examination [6].…”

Section: Introductionmentioning

confidence: 99%

Unique Case of Rare Non-Neural Granular Cell Tumor of the Rectus Abdominis Muscle

Kiskinov,

Palavurov,

Mollova-Kyosebekirova

et al. 2024

Medicina

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Background and Objectives: Our report contributes a unique case of a non-neural GCT occurring in an unusual location, with its development during pregnancy adding to its rarity. Materials and Methods: Granular cell tumors (GCTs), also known as Abrikossoff’s tumors, are rare neoplasms of Schwann cell origin with predominantly benign behavior. We present a case of a 29-year-old female with a non-neural variant of a GCT discovered incidentally during a cesarean section, situated on the posterior surface of the rectus abdominis muscle. Results: Histologically, the tumor exhibited features consistent with a benign non-neural GCT, confirmed through an immunohistochemical analysis. Despite the atypical presentation and challenging surgical removal due to prior scarring, the patient experienced no postoperative complications and showed no signs of recurrence during follow-up. Conclusions: This case highlights the importance of considering GCTs in differential diagnoses, particularly in unusual anatomical locations, and underscores the favorable prognosis associated with timely surgical intervention.

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Primitive non-neural granular cell tumor: Literature review

Cited by 4 publications

References 33 publications

Dermatofibroma‐like dermal non‐neural granular cell tumor

Dermatofibroma‐like dermal non‐neural granular cell tumor

ALK Positive Non-Neural Granular Cell Tumour in Two Paediatric Patients- A Case Report

Unique Case of Rare Non-Neural Granular Cell Tumor of the Rectus Abdominis Muscle

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