Ruxolitinib-conjugated gold nanoparticles for topical administration: An alternative for treating alopecia?

Boca, Sanda; Berce, Cristian; Jurj, Ancuța; Petrushev, Bobe; Pop, Laura; Gafencu, Grigore; Selicean, Sonia; Moisoiu, Vlad; Temian, Daiana Cosmina; Micu, Wilhelm-Thomas; Aştilean, Simion; Braicu, Cornelia; Tomuleasa, Ciprian; Berindan‐Neagoe, Ioana

doi:10.1016/j.mehy.2017.09.023

Cited by 15 publications

(8 citation statements)

References 15 publications

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“…Boca et al [116] developed Topical Ruxolitinib loaded gold nanoparticles for the treatment of different skin disorders. The technique of electron microscopy was used to examine the inner side of developed novel Ruxolitinib conjugated gold nanoparticles and the techniques of cell counting, western blotting etc.…”

Section: Metallic Nanoparticlesmentioning

confidence: 99%

Recent Advances in Topical Nanotechnological Strategies for Treatment of Alopecia

Mehak

Singh

Nanda

et al. 2021

JPRI

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Alopecia can be characterized as a hair-related disorder leading to decreased hair growth, especially on the scalp. It has affected approximately 2% of the world population. The hair loss may emerge due to genetic or environmental factors like stress, infectious agents, tensile forces or medications. The pathogenetic pathway of induction of alopecia comprises of different factors, but exploitation of hair follicle immune privilege system (HFIP) is the most prominent one. Alopecia can be classified into two types: scarring alopecia or non-scarring alopecia. Although, many conventional dosage forms have been formulated against alopecia, but they have been associated with different adverse effects such as weight gain, palpitations, itching etc. In order to overcome the adverse effects associated with conventional dosage forms, the topical nano-formulations have been used for the treatment of dermatological disorders. Nano-formulations are known to increase the contact time of drug with the target site, thereby, achieving sustained and controlled release of the drug leading to enhanced therapeutic compliance. This review provides an in-depth study of developed nanocarriers like liposomes, nano-emulsions, ethosomes, solid lipid nanoparticles (SLNs), nanostructured lipid carriers (NLCs) along with their composition, method of preparation, results obtained after formulation, suitable use and along with their potential use in treatment of different forms of alopecia.

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Section: Metallic Nanoparticlesmentioning

confidence: 99%

Recent Advances in Topical Nanotechnological Strategies for Treatment of Alopecia

Mehak

Singh

Nanda

et al. 2021

JPRI

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“…This long-dreamed strategy to avoid the systemic side effects of drugs of interest is now technically possible and several options have now been developed (Figure 3), as evidenced by the newly designed nano-encapsulated JAKinibs baricitinib in 2019 [92]. In 2017, ruxolitinib-conjugated gold nanoparticles were designated for topical administration, 15 with a reduced systemic absorption into the blood flow [93]. Nanoparticles have a ligand that allow targeting of specific cells or tissue, ranging from a given organ [94] to immune cells subtypes such as macrophages [95], B cells [96] and T cells [97].…”

Section: Modulators Of the Jak-stat Pathways And Applicability In Sepsismentioning

confidence: 99%

JAK–STAT Targeting Offers Novel Therapeutic Opportunities in Sepsis

Clère-Jehl

Mariotte

Meziani

et al. 2020

Trends in Molecular Medicine

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“…Many drugs and small molecules, especially the hydrophobic ones, can be encapsulated in order to enter the gel for further medical applications. For instance, many nanosystems (metallic [125], lipid [126], polymeric [127], peptides [128]) are used for targeted delivery [129]. Nanoparticles are fashioned to ensure drug pharmacokinetics and pharmacodynamics [130].…”

Section: Hydrogel Functionalization With Therapeutic Agentsmentioning

confidence: 99%

Hydrogels Based Drug Delivery Synthesis, Characterization and Administration

et al. 2019

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Hydrogels represent 3D polymeric networks specially designed for various medical applications. Due to their porous structure, they are able to swollen and to entrap large amounts of therapeutic agents and other molecules. In addition, their biocompatibility and biodegradability properties, together with a controlled release profile, make hydrogels a potential drug delivery system. In vivo studies have demonstrated their effectiveness as curing platforms for various diseases and affections. In addition, the results of the clinical trials are very encouraging and promising for the use of hydrogels as future target therapy strategies.

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Ruxolitinib-conjugated gold nanoparticles for topical administration: An alternative for treating alopecia?

Cited by 15 publications

References 15 publications

Recent Advances in Topical Nanotechnological Strategies for Treatment of Alopecia

Recent Advances in Topical Nanotechnological Strategies for Treatment of Alopecia

JAK–STAT Targeting Offers Novel Therapeutic Opportunities in Sepsis

Hydrogels Based Drug Delivery Synthesis, Characterization and Administration

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