Rutin, a Flavonoid That Is a Main Component of<i>Saussurea involucrata</i>, Attenuates the Senescence Effect in D-Galactose Aging Mouse Model

Yang, Ying; Lin, Hsueh Yi; Su, Kang-Yi; Chen, Chien-Hsu; Yu, Yung Lung; Lin, Chai Ching; Yu, Sung-Liang; Yan, Hong; Su, Kuo Jung; Chen, Yi Lin Sophia

doi:10.1155/2012/980276

Cited by 37 publications

(23 citation statements)

References 43 publications

(37 reference statements)

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“…active caspases-3, one of the major apoptotic mediator, is implicated in the biochemical cascades of apoptosis in the brain, and leads to neurodegeneration (Yang et al 2012). FA ameliorated nerve injury in cerebral ischemia model of rats (Zhang et al 2015).…”

Section: Discussionmentioning

confidence: 99%

Ferulic acid ameliorates memory impairment in d-galactose-induced aging mouse model

Yang

Zhang

et al. 2016

International Journal of Food Sciences and Nutrition

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Ferulic acid (FA) acts as a powerful antioxidant against various age-related diseases. To investigate the effect and underlying mechanism of FA against d-galactose(d-gal)-induced memory deficit, mice were injected with d-gal to induce memory impairment and simultaneously treated with FA and donepezil. The behavioral results revealed that chronic FA treatment reversed d-gal-induced memory impairment. Further, FA treatment inhibited d-gal-induced AChE activity and oxidative stress via increase of superoxide dismutase activity and reduced glutathione content, as well as decrease of malondialdehyde and nitric oxide levels. We also observed that FA significantly inhibits inflammation in the brain through reduction of NF-κB and IL-1β by enzyme-linked immunosorbent assay. Additionally, FA treatment significantly reduces the caspase-3 level in the hippocampus of d-gal-treated mice. Hematoxylin and eosin and Nissl staining showed that FA prevents neurodegeneration induced by d-gal. These findings showed that FA inhibits d-gal-induced AChE activity, oxidative stress, neuroinflammation and neurodegeneration, and consequently ameliorates memory impairment.

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Section: Discussionmentioning

confidence: 99%

Ferulic acid ameliorates memory impairment in d-galactose-induced aging mouse model

Yang

Zhang

et al. 2016

International Journal of Food Sciences and Nutrition

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“…The model selected was daily administration of D-galactose, a reducing sugar which can be converted into aldose and hydro peroxide, resulting in anion superoxide and ROS production, such as hydrogen peroxide and superoxide radicals [8]. Systemic administration of D-galactose triggers ROS formation in mitochondria and enhances advanced glycation end (AGE) products through activation of their receptor RAGE.…”

Section: Introductionmentioning

confidence: 99%

Exendin-4 protects mice from D-galactose-induced hepatic and pancreatic dysfunction

Ahangarpour

Oroojan

Badavi

2017

Pathobiology of Aging & Age-related Diseases

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Investigations into pharmaceutical intervention of pancreatic and hepatic dysfunction associated with metabolic disturbances have received relatively little attention. The aim of this study was to investigate the protective effects of exendin-4 in mice receiving D-galactose, a reducing sugar that triggers ROS production and inflammatory mediators affecting the pancreas and liver. Exendin-4 is an United States Food and Drug Administration (FDA) approved glucagon-like peptide that increases insulin dependent glycogen synthesis and glucose uptake. Male NMRI mice (20–25 g), 3 months of age, were randomly divided into 6 groups of 12 mice each: control, exendin-4 (1 nmol/kg), exendin-4 (10 nmol/kg), D-galactose, D-galactose + exendin-4 (1 nmol/kg) and D-galactose + exendin-4 (10 nmol/kg). D-galactose (500 mg/kg) was given daily by oral gavage for 6 weeks. During the last 10 days, exendin-4 (1 and 10 nmol/kg) was injected intraperitoneally daily. Glucose, insulin, insulin resistance, lipid profiles, and hepatic enzyme levels significantly increased in the D-galactose group (p < 0.05), along with a significant decrease in superoxide dismutase activity and pancreatic islet insulin secretion (p < 0.05). Exendin-4 decreased D-galactose-induced increases in serum glucose and insulin, insulin resistance, lipid profiles, and hepatic enzymes, and improved pancreatic islet insulin secretion and antioxidant defense status. The results show that exendin-4 can prevent complications in mice with compromised pancreatic and hepatic function. Long term administration of D-galactose in mice may be a useful model to study insulin resistance, metabolic syndrome, and aging.

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“…S. Involucrate is currently close to extinction and, therefore, listed as a second-grade national protected wild plant in China [20, 21]. According to the theories of traditional Chinese medicine, S. Involucrata has the effects of warming the kidney, activating “yang,” expelling wind, eliminating dampness, inducing menstruation, and promoting blood circulation [22]. Hispidulin (40,5,7-trihydroxy-6-methoxyflavone) is a naturally occurring flavone in S. Involucrata [20].…”

Section: Introductionmentioning

confidence: 99%

Potential Therapeutic Role of Hispidulin in Gastric Cancer through Induction of Apoptosis via NAG-1 Signaling

Lee

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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Gastric cancer is one of the most common malignant cancers due to poor prognoses and high mortality rates worldwide. However, an effective chemotherapeutic drug without side effects remains lacking. Saussurea involucrata (SI) Kar. et Kir., also known as snow lotus, grows in mountainous rocky habitats at 2600 m elevation in the Tian Shan and A'er Tai regions of China. The ethyl acetate extract of SI had been shown to inhibit proliferation and induce apoptosis in various tumor cells. In this study, we demonstrated that Hispidulin, active ingredients in SI, inhibits the growth of AGS gastric cancer cells. After Hispidulin treatment, NAG-1 remained highly expressed, whereas COX-2 expression was downregulated. Flow cytometric analysis indicated that Hispidulin induces G1/S phase arrest and apoptosis in time- and concentration-dependent manners. G1/S arrest correlated with upregulated p21/WAF1 and p16 and downregulated cyclin D1 and cyclin E, independent of p53 pathway. In addition, Hispidulin can elevate Egr-1 expression and ERK1/2 activity, whereas ERK1/2 inhibitor markedly attenuated NAG-1 mediated apoptosis. Taken together, Hispidulin can efficiently activate ERK1/2 signaling followed by NAG-1 constitutive expression and trigger cell cycle arrest as well as apoptosis in cancer cell. It can be a potential compound for combination therapy of gastric cancer in the future.

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Rutin, a Flavonoid That Is a Main Component ofSaussurea involucrata, Attenuates the Senescence Effect in D-Galactose Aging Mouse Model

Cited by 37 publications

References 43 publications

Ferulic acid ameliorates memory impairment in d-galactose-induced aging mouse model

Ferulic acid ameliorates memory impairment in d-galactose-induced aging mouse model

Exendin-4 protects mice from D-galactose-induced hepatic and pancreatic dysfunction

Potential Therapeutic Role of Hispidulin in Gastric Cancer through Induction of Apoptosis via NAG-1 Signaling

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