Ruthenium hydrazone complexes with 1:1 and 1:2 metal–ligand stoichiometry: a comparison of biomolecular interactions and in vitro cytotoxicities

Eswaran, Jayanthi; Sankar, Neethu K.; Bhuvanesh, Nattamai; Velusamy, Kaveri M.

doi:10.1007/s11243-018-00303-1

Cited by 11 publications

(2 citation statements)

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“…The rang of move and hypochromism are generally found to correlate with the intercalative binding strength. [ 53 ] The absorption spectra of ligand H 2 L B , B1, B 3 and A 1 , A 3 in the absence and in presence of herring sperm DNA are shown in (Table 6) and Figure 15–17. Upon incremental additions of DNA to test compounds, the following changes were observed.…”

Section: Resultsmentioning

confidence: 99%

Quantum chemical studies and effect of gamma irradiation on the spectral, thermal, X‐ray diffraction and DNA interaction with Pd (II), Cu(I), and Cd (II) of hydrazone derivatives

Aly

Elganzory

Mahross

et al. 2021

Applied Organom Chemis

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A new series of Pd (II), Cd (II), and Cu(I) complexes with ((Z)‐2‐(phenylamino)‐N′‐(thiophen‐2‐ylmethylene)acetohydrazide)(H2LB) has been prepared. FT‐IR, 1H‐NMR, electronic spectra, Powder X‐ray, thermal behavior, theoretical methods and DNA interaction of ligand and of Pd (II) and Cu(I) complexes before and after γ‐irradiation are studied. The 1H NMR spectrum of the ligand after γ‐irradiation shows the signals appear at the same position or slightly shift, but the intensity of the bands after γ‐irradiation is higher than before irradiated. X‐ray diffraction (XRD) studies exhibited the samples in nanorange, the crystallite size is 1.94, 4.81 nm for both unirradiated (B1 and B3) and 2.93, 4.72 nm for irradiated (A1 and A3). The thermal stability of the complexes after γ‐irradiation increase than before γ‐irradiation. The possible structures of the metal complexes have been computed using the molecular mechanic calculations UFF using quantum chemical software by Gaussian 09 W program. The calculations are performed with DFT/B3LYP/LANL2DZ to obtain the optimized molecular geometry. Some important quantum chemical descriptors of the metal complexes were calculated such as HOMO, LUMO, and energy gap. Metal complexes before and after irradiation in the absence and presence of increasing amounts of CT‐DNA exhibit that the absorption intensities decrease with increasing the concentration of DNA.

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Section: Resultsmentioning

confidence: 99%

Quantum chemical studies and effect of gamma irradiation on the spectral, thermal, X‐ray diffraction and DNA interaction with Pd (II), Cu(I), and Cd (II) of hydrazone derivatives

Aly

Elganzory

Mahross

et al. 2021

Applied Organom Chemis

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show abstract

“…To gain further insights into the microenvironmental changes around the tryptophan or tyrosine residues of BSA, synchronous spectral studies were conducted. 43 2.7.2. Synchronous spectral studies.…”

Section: 7mentioning

confidence: 99%