Ruthenium‐Catalyzed Benzylic CH Functionalization

Abstract

The activation and functionalization of the benzylic CH bond by transition metal catalysts have gathered much attraction owing to their occurrence in agrochemicals, pharmaceuticals, and fine chemicals. Among the various active metal catalysts, ruthenium gained upper hand, as they are comparatively economic as well as show versatile catalytic activity. Ruthenium efficiently activates the benzylic C(sp 3 )H bond and effects alkylation, arylation, allylation, vinylation, cyanation, silylation, amination, amidation, and oxidation reactions.

Ruthenium(ii)-catalyzed oxidative dehydrogenation and hydroarylation of maleimides with phthalazinones – insights into additive-controlled product selectivity

“…3 Among transition metal catalysts, ruthenium gained considerable traction owing to its low price and versatility. 4 The assemblage of phthalazinones, maleimides, and succinimides with the intervention of chelation-assisted ruthenium catalysis will leverage access to a bounty of bioactive products. Individually, phthalazinone scaffolds provide antiproliferative, antibacterial, antifungal, anti-inflammatory, and anticancer activities.…”