“…A broad range of medicinal properties are reported for quinazolinones, such as anticancer [23][24][25][26][27], antibacterial [28][29][30], antifungal [31][32][33][34][35], antimalarial [36], antiviral [37,38] as well as anti-microbial cholinesterase inhibitors [39,40], making quinazolinone a privileged class of N-containing heterocyclic scaffolds ( Figure 1). Due to diverse biological applications in pharmaceutical industry numerous synthetic methodologies were developed for the synthesis of quinazolinones [41][42][43][44][45][46][47][48][49][50][51][52][53][54][55][56][57][58]. These methods furnish the quinazolinones through reactions of readily available anthranilamide (2-aminobenzamide) with aldehydes, alcohols, esters, carboxylic acids, methyl arenes and amines under harsh reaction conditions in the presence of transition metals, etc.…”