Russian Non-Interventional Study of the Efficacy and Tolerability of Rifaximin-α Therapy in Patients with Uncomplicated Diverticular Disease under the Conditions of Outpatient Practice

Шифрин, О. С.; Poluektova, Elena; Королёв, А. В.; Семенова, Т. И.; Шеин, М. В.; Лексикова, Г. Н.; Токарева, О. А.; Давыдова, О Е; Андреев, П. С.; Каторкин, С. Е.; Chernov, Anton A.; Журавлев, А. В.; Сек, О. С.; Копина, А. А.; Самохина, Н. Ю.; Горожанкина, Ю. В.; Самигуллин, М. Ф.; Грошилин, В. С.; Borisova, Evgeniia; Петрова, Тамара Аркадьевна; Пирогова, И. Ю.; Медников, С. В.; Смагина, Н. В.; Сарсенбаева, А. С.; Smirnova, Nadezhda V.; Кирсанова, Л. Г.; Малютина, Н. М.; Смирнова, М. А.; Шлейкова, Е. Н.; Ивашкин, В. Т.

doi:10.22416/1382-4376-2020-30-1-14-25

Cited by 2 publications

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References 17 publications

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“…Приверженность лечению участников исследования, успешно завершивших курс эрадикационного лечения, оказалась высокой. Количество принятых больными таблеток от необходимого числа, назначенных на весь период лечения, составило 99,8 ± 0,1% [8].…”

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Evaluation of the dynamics of symptoms of dyspepsia after eradication therapy in patients with Helicobacter pylori-associated gastritis

Жесткова

2023

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The treatment of functional dyspepsia remains a complex and incompletely resolved issue of gastroenterology. Subjective sensations of the patient, described as a feeling of fullness in the epigastrium after eating, early satiety, pain in the epigastrium, may be a manifestation of dyspepsia associated with Helicobacter pylori (H. pylori) infection. Aim was evaluation of the effectiveness of standard triple eradication therapy enhanced with bismuth tripotassium dicitrate for the relief of symptoms of dyspepsia in patients with H. pylori-associated chronic gastritis. Materials and Methods. The study involved 38 patients with H. pylori-associated chronic gastritis with symptoms of dyspepsia. The Questionnaire “7 × 7” was used to describe the dynamics of symptoms of dyspepsia. Results. At the initial examination, dyspeptic disorders in most patients corresponded the criteria for mild and moderate severity, respectively - 44.7% and 28.9% of patients. The severity of pain in the stomach area on average corresponded to a moderate pain syndrome, and the burning sensation was of low intensity. A feeling of fullness in the stomach after eating and/or early satiety was experienced by 76.3% of patients, pain disorders were observed in 92.1% of individuals. Two months after successful eradication treatment, complete relief of dyspepsia symptoms was noted in 57.9% of patients, and significant relief of symptoms of the combined form of dyspepsia in 23.7% of individuals. Conclusions: Successful standard triple eradication therapy enhanced with bismuth tripotassium dicitrate is effective for the treatment of dyspeptic symptoms in patients with H. pylori-associated chronic gastritis.

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Section: результаты и обсуждениеunclassified

Evaluation of the dynamics of symptoms of dyspepsia after eradication therapy in patients with Helicobacter pylori-associated gastritis

Жесткова

2023

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Pregnancy and Healthy Childbirth in a 37 Year-Old Patient with Diverticular Disease

Андреев

Каторкин

Давыдова

2020

Rossijskij žurnal gastroènterologii, gepatologii, koloproktolog

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Aim. To describe a clinical case of pregnancy and healthy labour in a young female patient with uncomplicated diverticular disease (DD).Key points. In recent years, DD is more frequently observed in younger patients. A 37-yo woman manifested the symptoms of periodic intense abdominal pain and constant abdominal discomfort. Colonic DD was diagnosed with irrigoscopy. A high-fibre diet, rifaximin-α at 400 mg twice a day for one week, once a month for six months, and topical anti-inflammatory therapy were prescribed. Clinical symptoms were eradicated upon the treatment. Unaware of pregnancy, the patient had another course of rifaximin-α at the second week of gestation, after which the therapy was stopped. Rifaximin-α, which has a poor intestinal absorption, did not affect the foetal development. A caesarean childbirth was healthy, the newborn was delivered on term with no complications (Apgar score 8).Conclusion. DD should be included in differential diagnosis for patients with non-specific symptoms (abdominal pain, bloating and discomfort), regardless of young age. No protocols are currently accepted for the DD management during gestation. In the clinical case reported, a patient having diverticular disease and a rifaximin-α therapy at an early term of gestation proceeded without complications for herself and the foetus.

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Russian Non-Interventional Study of the Efficacy and Tolerability of Rifaximin-α Therapy in Patients with Uncomplicated Diverticular Disease under the Conditions of Outpatient Practice

Cited by 2 publications

References 17 publications

Evaluation of the dynamics of symptoms of dyspepsia after eradication therapy in patients with Helicobacter pylori-associated gastritis

Evaluation of the dynamics of symptoms of dyspepsia after eradication therapy in patients with Helicobacter pylori-associated gastritis

Pregnancy and Healthy Childbirth in a 37 Year-Old Patient with Diverticular Disease

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