Ruptured spleen associated with chicken-pox.

Tapp, E.

doi:10.1136/bmj.1.5644.617

Cited by 9 publications

(6 citation statements)

References 6 publications

(4 reference statements)

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“…In these cases, the diagnosis of VZV-related ASR was made because the typical rash was present in all cases, preceding the onset of abdominal pain, and additional viral serological tests were negative. In addition, Tapp4 confirmed the diagnosis by the presence of vesicles and pustules on the serosal surface of abdominal viscera and their presence on splenic histological sections. Harris and Boland5 confirmed the diagnosis by positive viral serology for VZV IgM and IgG, and splenic histological sections, demonstrating reactive follicular hyperplasia and infiltration of lymphocytes, as with our case (figures 2 and 3).…”

Section: Discussionmentioning

confidence: 63%

Varicella zoster virus infection is an unusual cause of splenic rupture

et al. 2015

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A 22-year-old man presented with a 1-day history of severe abdominal pain. He developed a generalised vesicular rash 12 h prior to admission. On examination, he was maximally tender with peritonism in the lower abdomen. Working diagnosis was perforated appendix and a decision to investigate with CT was made, which showed intra-abdominal haemorrhage likely arising from a ruptured spleen. After a period of observation, he subsequently underwent laparotomy and emergency splenectomy. Viral PCR from vesicular fluid was positive for varicella zoster virus. Viral serology was otherwise negative.

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Section: Discussionmentioning

confidence: 63%

Varicella zoster virus infection is an unusual cause of splenic rupture

et al. 2015

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“…Splenomegaly [ 7 ], and increased uptake in the spleen seen on Positron emission tomography- computed tomography (PET-CT) [ 8 ], has been described in primary VZV infection. Macroscopic splenic nodularity is also described in the setting of primary VZV infection [ 9 ]. However, there are only five reports of splenic rupture occurring in the setting of primary VZV infection [ 9 – 13 ].…”

Section: Discussionmentioning

confidence: 99%

“…Macroscopic splenic nodularity is also described in the setting of primary VZV infection [ 9 ]. However, there are only five reports of splenic rupture occurring in the setting of primary VZV infection [ 9 – 13 ]. All cases are reported in young, adult males, as with our case [ 9 – 13 ].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Spontaneous splenic rupture complicating primary varicella zoster infection: a case report

Uthayakumar

Harrington

2018

BMC Res Notes

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BackgroundPrimary varicella zoster virus (VZV) infection is a common illness, predominantly affecting children. Its course is typically benign, although severe complications have been described. Splenic rupture is an extremely rare and potentially fatal complication of primary VZV infection, with only a handful of cases reported in the literature.Case PresentationA 32-year-old Romanian man with no significant past medical history, presented with a 2 day history of sudden onset, worsening generalised abdominal pain and a 1 day history of vomiting. The following day he developed fevers and a generalised widespread erythematous rash consisting of clusters of macules, papules and vesicles at different stages of development. There was no history of sore throat, coryza, arthralgia, myalgia, cough, shortness of breath, weight loss, or night sweats. There was no recent illness and no history of trauma. CT abdomen showed splenic rupture with intra-abdominal haemorrhage. Admission bloods showed anaemia and thrombocytopenia, with haemoglobin 110 g/l and platelets 78 × 109/l. Viral PCR of vesicle fluid from the rash was positive for VZV DNA confirming the clinical diagnosis of primary varicella zoster infection. Viral serology also confirmed recent infection. He was haemodynamically resuscitated, and underwent laparotomy and splenectomy. He was commenced on IV acyclovir and completed a 5 day course. Prior to discharge he was commenced on recommended splenectomy secondary prevention treatment.ConclusionThere are several reported complications of varicella infection, more commonly in the immunocompromised population. Spontaneous splenic rupture is an unusual complication of primary VZV infection. Here we report the sixth known case in the literature. Splenic rupture should be considered in cases of primary varicella in young adults presenting with abdominal pain.

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“…The most common infections presented by this review were malaria (65 reports) and EBV (42 reports). An extended literature search identified only 3 other cases of varicella induced spontaneous splenic rupture [ [11] , [12] , [13] ] making this the 5th reported case in the literature. All reported cases have shared features in the patient demographics of a young male and expected dermatological findings for VZV preceding the onset of abdominal pain.…”

Section: Discussionmentioning

confidence: 99%