Rupture point analysis of intestinal anastomotic healing in rats under the action of pure Copaíba (Copaifera Iangsdorfii) oil

Abstract

PURPOSE: Analyze the mechanical strength of digestive tract scar after intestinal anastomosis surgery in animals treated with pure Copaíba oil. METHODS: 60 Wistar rats, male, about 250 days old and weighting around 350g were used. The rats were randomly divided into two groups: Group O, with 30 animals that received Copaíba oil and Group C, with 30 animals that received saline. Each group was subdivided into three subgroups, containing 10 rats each. They were designated O7, O14, O28, C7, C14 and C28, according to the post-operative assessment date at 7, 14 and 28 days, respectively. On these dates euthanasia was performed with the removal of the bowel segment containing the anastomosis and assigning the samples to tensile test for assessing Maximum Stress, Maximum Tensile Strength and Maximum Rupture Strength. RESULTS: On the three variables of the study, the results indicate that, for the three assessment periods (7, 14 and 28 days) there was no significant difference between the oil and control groups. CONCLUSION: For the mechanical tests proposed by this study, Copaíba oil didn´t show any effectiveness in increasing the anatomosis strength.

Wound healing properties of Copaifera paupera in diabetic mice

“…Another report related that oleoresin from C . langsdorffii had no effect on wound healing in intestinal mucosa [ 19 ]. This diversity of effects can be attributed to different species from which oleoresin was obtained, leading to a different chemical composition that would inevitably lead to a different pharmacological outcome.…”

Chemistry and Biological Activities of Terpenoids from Copaiba (Copaifera spp.) Oleoresins

“…Also, according to Comelli, Jr et al . [ 29 ] the crude C. langsdoffii oleoresin has no effect on wound healing in intestinal mucosa of rats oil-treated orally. On the other hand, Paiva et al [ 27 ] investigated the activity of wound healing in rats treated with copaiba oleoresin from C. langsdorffii , and obtained results that allowed them to affirm the benefits of this copaiba oleoresin, justifying its traditional use.…”

Genotoxicity assessment of Copaiba oil and its fractions in Swiss mice

“…Studies on the medicinal plants in northern Brazil have been well documented in the medical literature, especially as regards Copaiba oil-resin ( Tappin et al , 2004 ; Comelli Júnior et al , 2010 ), and its manifold therapeutic properties – antiinflammatory, antitumoral, antimelanoma, antiulcerogenic, antilipoperoxidation and antioxidant ( Ohsaki et al , 1994 ; Paiva et al , 2002 ; Gomes et al , 2007 ; Silva et al , 2009 ; dos Santos et al , 2010 ). Furthermore, new lines of research have been developed, with the aim of analyzing the chemical components involved.…”

“…Furthermore, new lines of research have been developed, with the aim of analyzing the chemical components involved. There is, for example, evidence of healing and antiinflammatory properties in certain fractions of the diterpenes, sesquiterpenes, and kaurenoic and polyaltic acids, present in the pure oil ( Tappin et al , 2004 ; Comelli Júnior et al , 2010 ).…”