RUNX1 and cancer

Lin, Tsung-Chieh

doi:10.1016/j.bbcan.2022.188715

Cited by 47 publications

(34 citation statements)

References 78 publications

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“…RUNX1 has been identified as a critical transcription factor regulating multiple biological processes of cancer ( 49 ). However, the potential regulatory role of RUNX1 on CD44 has not been explored.…”

Section: Discussionmentioning

confidence: 99%

RUNX1/CD44 axis regulates the proliferation, migration, and immunotherapy of gliomas: A single-cell sequencing analysis

et al. 2023

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BackgroundGlioma is one of the most common, primary, and lethal adult brain tumors because of its extreme aggressiveness and poor prognosis. Several recent studies relevant to the immune function of CD44, a transmembrane glycoprotein as a significant hyaluronic acid receptor, have achieved great success, revealing the critical role of CD44 in immune infiltration in gliomas. The overexpression of CD44 has been verified to correlate with cancer aggressiveness and migration, while the clinical and immune features of CD44 expression have not yet been thoroughly characterized in gliomas.MethodsMolecular and clinical data of glioma collected from publicly available genomic databases were analyzed.ResultsCD44 was up-expressed in malignant gliomas, notably in the 1p/19q non-codeletion cases, isocitrate dehydrogenase (IDH) wild-type, and mesenchymal subtypes in GBM samples. CD44 expression level strongly correlates with stromal and immune cells, mainly infiltrating the glioma microenvironment by single-cell sequencing analysis. Meanwhile, CD44 can be a promising biomarker in predicting immunotherapy responses and mediating the expression of PD-L1. Finally, RUNX1/CD44 axis could promote the proliferation and migration of gliomas.ConclusionsTherefore, CD44 was responsible for glioma growth and progression. It could potentially lead to a novel target for glioma immunotherapy or a prognostic biomarker.

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Section: Discussionmentioning

confidence: 99%

RUNX1/CD44 axis regulates the proliferation, migration, and immunotherapy of gliomas: A single-cell sequencing analysis

et al. 2023

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“…Importantly, the interaction controls RUNX transcription factor activity and Notch signaling during blood cell development in vivo ( 43 ). RUNX members are key regulators of hematopoiesis; particularly, RUNX1 functions as a positive regulator for definitive hematopoietic stem cell emergence and megakaryocyte and lymphocyte differentiation ( 44 ). RUNX1-ETO, the mutant and infusion form of the RUNX1 protein, has been identified in cancer.…”

Section: Mlf1 Networkmentioning

confidence: 99%

Myeloid leukemia factor 1: A “double-edged sword” in health and disease

Yang²,

Wu³

et al. 2023

Front. Oncol.

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The occurrence and development of malignancies are closely related to abnormal cell cycle regulation. Myeloid leukemia factor 1 (MLF1) is a small nucleocytoplasmic shuttling protein associated with cell cycle exit, apoptosis, and certain immune functions. Therefore, it is pertinent to explore the role of MLF1 in health and diseases. Studies to date have suggested that MLF1 could act as a double-edged sword, regulating biochemical activities directly or indirectly. In hematopoietic cells, it serves as a protective factor for the development of lineages, and in malignancies, it serves as an oncogenesis factor. The diversity of its functions depends on the binding partners, including tumor inhibitors, scaffolding molecules, mitochondrial membrane proteins, and transcription factors. Emerging evidence indicates that MLF1 influences immune responses as well. This paper reviews the structure, biological function, and research progress on MLF1 in health and diseases to provide new insights for future research.

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“… [ 25 , 58 ] Tumorigenesis Runx1 has indirect and direct biological functions in modulating cancer metastasis, proliferation, angiogenesis, cancer stemness and chemoresistance to anticancer drugs. [ 59 , 60 ] Cartilage and bone Runx1 is vital for the early stages of chondrogenesis and osteogenesis, and the homeostasis of skeleton system. [ 61 , 62 , 70 ] Hair follicles Runx1 controls timely emergence of hair follicle stem cells and proper maturation during embryogenesis.…”

Section: The Overview Of Runx1mentioning

confidence: 99%