Running, swimming and diving modifies neuroprotecting globins in the mammalian brain

Williams, Terrie M.; Zavanelli, M I; Miller, Melissa A.; Goldbeck, Robert A.; Morledge, Michael; Casper, Dave; Pabst, D. Ann; McLellan, William A.; Cantin, Lucas P; Kliger, David S.

doi:10.1098/rspb.2007.1484

Cited by 53 publications

(40 citation statements)

References 32 publications

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“…Nevertheless, such spectral differencing strategy underpins current determination of heme proteins, such as neuroglobin (Williams et al, 2008 (Jue, 1994). The HbCO -CH 3 Val E11 signals of the a and b subunits appear at -1.72p.p.m.…”

Section: Determining the Myoglobin Concentration In Musclesmentioning

confidence: 99%

Myoglobin's old and new clothes: from molecular structure to function in living cells

Gros

Wittenberg

Jue

2010

Journal of Experimental Biology

100

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SUMMARY Myoglobin, a mobile carrier of oxygen, is without a doubt an important player central to the physiological function of heart and skeletal muscle. Recently, researchers have surmounted technical challenges to measure Mb diffusion in the living cell. Their observations have stimulated a discussion about the relative contribution made by Mb-facilitated diffusion to the total oxygen flux. The calculation of the relative contribution, however, depends upon assumptions, the cell model and cell architecture, cell bioenergetics, oxygen supply and demand. The analysis suggests that important differences can be observed whether steady-state or transient conditions are considered. This article reviews the current evidence underlying the evaluation of the biophysical parameters of myoglobin-facilitated oxygen diffusion in cells, specifically the intracellular concentration of myoglobin, the intracellular diffusion coefficient of myoglobin and the intracellular myoglobin oxygen saturation. The review considers the role of myoglobin in oxygen transport in vertebrate heart and skeletal muscle, in the diving seal during apnea as well as the role of the analogous leghemoglobin of plants. The possible role of myoglobin in intracellular fatty acid transport is addressed. Finally, the recent measurements of myoglobin diffusion inside muscle cells are discussed in terms of their implications for cytoarchitecture and microviscosity in these cells and the identification of intracellular impediments to the diffusion of proteins inside cells. The recent experimental data then help to refine our understanding of Mb function and establish a basis for future investigation.

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Section: Determining the Myoglobin Concentration In Musclesmentioning

confidence: 99%

Myoglobin's old and new clothes: from molecular structure to function in living cells

Gros

Wittenberg

Jue

2010

Journal of Experimental Biology

100

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“…They have evolved physiological (e.g. increased levels of globins for more efficient oxygen transfer [45]), morphological (e.g. feeding apparatus such as baleen) and behavioural traits (e.g.…”

Section: (D) Body Size Diet and Environmentmentioning

confidence: 99%

Examining predator–prey body size, trophic level and body mass across marine and terrestrial mammals

Tucker

Rogers

2014

Proc. R. Soc. B.

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Predator-prey relationships and trophic levels are indicators of community structure, and are important for monitoring ecosystem changes. Mammals colonized the marine environment on seven separate occasions, which resulted in differences in species' physiology, morphology and behaviour. It is likely that these changes have had a major effect upon predator-prey relationships and trophic position; however, the effect of environment is yet to be clarified. We compiled a dataset, based on the literature, to explore the relationship between body mass, trophic level and predator-prey ratio across terrestrial (n ¼ 51) and marine (n ¼ 56) mammals. We did not find the expected positive relationship between trophic level and body mass, but we did find that marine carnivores sit 1.3 trophic levels higher than terrestrial carnivores. Also, marine mammals are largely carnivorous and have significantly larger predator-prey ratios compared with their terrestrial counterparts. We propose that primary productivity, and its availability, is important for mammalian trophic structure and body size. Also, energy flow and community structure in the marine environment are influenced by differences in energy efficiency and increased food web stability. Enhancing our knowledge of feeding ecology in mammals has the potential to provide insights into the structure and functioning of marine and terrestrial communities.

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“…The role of globins in the brain seems to be pivotal to support nervous system functions during temporary periods of hypoxia, which may follow environmental or pathologic insults, therefore avoiding serious damages to the nervous system (21)(22)(23)(24)(25).…”

Section: Introductionmentioning

confidence: 99%

Neuroglobin, estrogens, and neuroprotection

2011

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SummaryGlobins have been found in glial cells and neurons of invertebrates and vertebrates. The first nerve globin has been recognized in the nerve cord of the polychaete annelid Aphrodite aculeata in 1872. In some invertebrates, the nerve globin reaches a millimolar concentration which is likely sufficient to sustain the aerobic metabolism and thus the excitability of the nervous system. In 2000, the first vertebrate nerve globin, named neuroglobin (Ngb), has been identified in neuronal tissues of mice and humans. In contrast to invertebrate nerve globins, the concentration of Ngb, the prototype of vertebrate nerve globins, is low (lM), reaching a maximum of 100 lM in retina cells. Therefore, Ngb appears unlikely to act primarily as an O 2 buffer and to facilitate O 2 diffusion to the mitochondria. Indeed, Ngb has been hypothesized to catalyze the formation/decomposition of reactive nitrogen and/or oxygen species and to be part of intracellular signaling pathways enhancing cell survival. Here, we report that neuronal Ngb levels are strongly induced by the steroid hormone 17b-estradiol. Furthermore, Ngb participates to mechanisms involved in 17b-estradiol-induced protective effects against H 2 O 2 -induced neurotoxicity.

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Running, swimming and diving modifies neuroprotecting globins in the mammalian brain

Cited by 53 publications

References 32 publications

Myoglobin's old and new clothes: from molecular structure to function in living cells

Myoglobin's old and new clothes: from molecular structure to function in living cells

Examining predator–prey body size, trophic level and body mass across marine and terrestrial mammals

Neuroglobin, estrogens, and neuroprotection

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