Rue the Herb: Ruta graveolens-Associated Phytophototoxicity

Phytophotodermatitis due to homemade ointment for Pediculosis capitis

“…We draw attention to the particular and unreported pattern of presentation evidenced in our patient, resembling that observed in the classic perfume‐induced berloque dermatitis. Physicians should be aware that an initial inflammatory reaction may be subtle or unrecognized by the patient and, as it was the case of our patient, only hyperpigmentation is evident (5, 11).…”

Photoactive plants: Botany bad boys or horticultural heroes?

“…These recreational injuries may be “powered” by direct sunlight or internal ultraviolet lighting. The application of Rue ( Ruta graveolens ) as an insect repellent has also been noted to cause phytophotodermatitis (Eickhorst et al, ), as has the wearing of Hawaiian leis (as neck garlands) made of the fruits of Pelea anisata (Elpern & Mitchell, ). As noted, phytophotodermatitis is often attributed to the ultraviolet‐absorbing furocoumarins, which have both photochemical and photodynamic activities when exposed to light of the correct wavelength.…”

Rutaceae Juss.

“…Poisoning is reported to be due to the essential oils, especially methyl n-nonyl ketone, which may cause nausea, vomiting, salivation, gastroenteritis, and possibly collapse but rarely death. In severe cases, hospitalization may be required (Eickhorst et al 2007). This may last for several days, and in severe cases residual hyperpigmentation may develop at the site and persist for several months (Mitchell and Rook 1977).…”