Rubella seroprevalence in pregnant women at the military teaching hospital, Rabat, Morocco

Belefquih, Bouchra; Kasouati, Jalal; Doblali, Taoufik; Touil, Nadia; Tagajdid, Mohamed Rida; Kabbaj, Hakima; Annaz, Hicham El; Mrani, Saâd

doi:10.1016/j.ijgo.2012.08.026

Cited by 5 publications

(6 citation statements)

References 4 publications

(6 reference statements)

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“…Also, the 14% seronegativity in the present study is consistent with the pooled average of 11% seronegativity that has been reported in a meta-analysis of 19 African studies among pregnant women 18. Nonetheless, the seropositivity rate of IgG antibody to RV in the studied pregnant women was lower than those found in previous studies in Rabat and Central Morocco, which were 90% and 88.6%, respectively 13 14. Furthermore, the rubella seroprevalence found in other studies was high, with a 95% seroprevalence among pregnant women in Finland and the Netherlands19 and a measured seroprevalence of 90% among pregnant women in Ontario 20.…”

Section: Discussionsupporting

confidence: 90%

“…The sample size was determined using data from previous studies in Morocco, while considering a 95% CI and a precision level of 5%. Studies on the seroprevalence of antirubella IgG in Morocco have reported that the overall prevalence among pregnant women in the military teaching hospitals of Rabat and Meknes was, respectively, 90.2% and 88.6% in 2012 and 2017 13 14. Therefore, a minimum number of 207 pregnant women were selected for enrolment in this study.…”

Section: Methodsmentioning

confidence: 99%

“…In Morocco, studies on the seroepidemiology of these congenital infections in the general Moroccan population are scarce. In fact, information on the seroprevalence of rubella among pregnant women and the burden of CRS remains rare and particularly limited 13 14. This study aimed to assess the current seroprevalence of antirubella antibodies in order to re-evaluate the level of protective immunity and risks among pregnant women in the region of Rabat.…”

Section: Introductionmentioning

confidence: 99%

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Rubella seroprevalence among pregnant women in the region of Rabat, Morocco: a cross-sectional study

et al. 2023

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ObjectivesThe aim of the present research is to update data on the seroprevalence of rubella and to identify the associated risk factors among pregnant women in the Rabat region of Morocco in order to take immediate action to monitor the virus.DesignA cross-sectional study.SettingThe study was conducted at Ibn Sina University Hospital and at referral healthcare centres in the region of Rabat.ParticipantsA total of 502 pregnant women (mean age 29.7±6.3 years, range 17–44 years) attending the maternity department during 8 months were selected for serological testing.Outcome measuresA structured questionnaire was used to obtain sociodemographic, reproductive and clinical characteristics after obtaining written informed consent. Venous blood samples were collected to determine rubella-specific IgG antibodies using an automated chemiluminescent microparticle immunoassay (ARCHITECT i1000SR and i2000SR, Abbott Diagnostics).ResultsAntirubella IgG antibodies (≥10 IU/mL) were found in 408 (85.9%) pregnant women examined. The rate of susceptibility to rubella virus infection among pregnant women was found to be 14.1%. These protective rates were found to differ significantly between uneducated pregnant women (80.9%) and those with university-level education (95.5%) (p=0.02). Pregnant women in the 17–24, 25–34 and 35–44 years age groups accounted for 92.5%, 85.2% and 82.8%, respectively (p=0.015). Also, IgG seropositivity status was found to differ significantly between multiparous (83.3%) and primiparous (92.5%) pregnant women (p=0.01). None of the other characteristics was significantly associated with rubella infections.ConclusionVaccination programmes need to be updated to ensure that campaigns reach their specified goals. Thus, implementing an effective, large-scale screening programme for congenital rubella infection in different regions of Morocco is highly recommended. On the other hand, seronegative pregnant women should be given special preventive care and health education about rubella transmission and congenital rubella syndrome sequelae.

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Section: Discussionsupporting

confidence: 90%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Rubella seroprevalence among pregnant women in the region of Rabat, Morocco: a cross-sectional study

et al. 2023

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“…The results are similar to those of previous studies in the African region, which have reported rubella seropositive estimates of 72-99% in women of reproductive age, 7,[16][17][18][19][20][21][22][23][24] and 53-95% in pregnant women. 18,[25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41] These serosurvey results and evidence from epidemiological investigations and CRS surveillance indicate that rubella virus is circulating on the African continent, causing rubella infections and CRS. 8,42 For pregnant women, rubella susceptibility is concerning because of the risk of CRS in the fetus.…”

Section: Discussionmentioning

confidence: 99%

Rubella immunity among pregnant women aged 15–44 years, Namibia, 2010

Jonas

Cardemil

Beukes³

et al. 2016

International Journal of Infectious Diseases

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“…We identified over 220 studies that provided cross‐sectional data and nearly 180 studies that reported on immunity for women of child‐bearing age, primarily for rubella. Table summarizes the over 400 cross‐sectional and women of child‐bearing age measles and rubella serological studies…”

Section: Resultsmentioning

confidence: 99%

Systematic Review of Measles and Rubella Serology Studies

Thompson

Odahowski²

2015

Risk Analysis

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Serological tests provide information about individual immunity from historical infection or immunization. Cross-sectional serological studies provide data about the age- and sex-specific immunity levels for individuals in the studied population, and these data can provide a point of comparison for the results of transmission models. In the context of developing an integrated model for measles and rubella transmission, we reviewed the existing measles and rubella literature to identify the results of national serological studies that provided cross-sectional estimates of population immunity at the time of data collection. We systematically searched PubMed, the Science Citation Index, and references we identified from relevant articles published in English. We extracted serological data for comparison to transmission model outputs. For rubella, serological studies of women of child-bearing age provide information about the potential risks of infants born with congenital rubella syndrome. Serological studies also document the loss of maternal antibodies, which occurs at different rates for the different viruses and according to the nature of the induced immunity (i.e., infection or vaccine). The serological evidence remains limited for some areas, with studies from developed countries representing a disproportionate part of the evidence. The collection and review of serological evidence can help program managers identify immunity gaps in the population, which may help them better understand the characteristics of individuals within their populations who may participate in transmission and manage risks.

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Rubella seroprevalence in pregnant women at the military teaching hospital, Rabat, Morocco

Cited by 5 publications

References 4 publications

Rubella seroprevalence among pregnant women in the region of Rabat, Morocco: a cross-sectional study

Rubella seroprevalence among pregnant women in the region of Rabat, Morocco: a cross-sectional study

Rubella immunity among pregnant women aged 15–44 years, Namibia, 2010

Systematic Review of Measles and Rubella Serology Studies

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