Rubella immunity among pregnant women aged 15–44 years, Namibia, 2010

Jonas, Anna; Cardemil, Cristina V.; Beukes, Anita; Anderson, Raydel; Rota, Paul A.; Bankamp, Bettina; Gary, Howard E.; Sawadogo, Souleymane; Patel, Sadhna; Zeko, Sikota; Muroua, Clementine; Gaeb, Esegiel; Wannemuehler, Kathleen; Gerber, Sue; Goodson, James L.

doi:10.1016/j.ijid.2016.05.009

Cited by 19 publications

(16 citation statements)

References 29 publications

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“…No statistically significant difference in rubella IgM and IgG positivity was found in relation to most socio-demographic characteristics of the pregnant women in this study. A similar finding was also reported in a recent study in Southern Ethiopia (Tamirat et al, 2017), and in other studies in Nigeria (Pennap and Egwa, 2016) and Namibia (Jonas et al, 2016). However, a statistically significant association between IgM positivity and area of residence was found in the present study; pregnant women from urban settings had two times the IgM positivity of those from rural settings.…”

Section: Discussionsupporting

confidence: 93%

“…The overall seroprevalence of rubella among pregnant women was found to be 89% (95% CI 86.3-91.3%). A similar finding has been reported from other African countries such as Senegal (90.1%) (Dromigny et al, 2003) and Namibia (85.0%) (Jonas et al, 2016). However, the overall seroprevalence in this study is higher than reports from other African countries like the Democratic Republic of Congo (58.97%) (Zanga et al, 2017), Sudan (65%) (Hamdan et al, 2011), and Nigeria (68%) (Bamgboye et al, 2004), and lower than reports from Burkina Faso (95%) (Tahita et al, 2013a,b) and Zimbabwe (92%) (Mamvura et al, 2015).…”

Section: Discussionsupporting

confidence: 90%

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Rubella virus infections and immune status among pregnant women before the introduction of rubella vaccine in Amhara Regional State, Ethiopia

Wondimeneh

Tiruneh

Ferede

et al. 2018

International Journal of Infectious Diseases

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A large number of pregnant women had acute/recent rubella virus infections at the time of data collection, indicating that the virus is endemic in the study area. More than a tenth of pregnant women were found to be susceptible to acquiring the infection in future pregnancies, with the possible risk of rubella-associated congenital anomalies. Hence screening of all women of child-bearing age before conception and during pregnancy might reduce the devastating effects of the virus on the developing fetus.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 90%

Rubella virus infections and immune status among pregnant women before the introduction of rubella vaccine in Amhara Regional State, Ethiopia

Wondimeneh

Tiruneh

Ferede

et al. 2018

International Journal of Infectious Diseases

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“…On the other hand, studies conducted in Burkinafaso, Senegal and Iran showed higher rubella seroprevalence (95.0, 90.1 and 96.2%, respectively) among pregnant women [22, 23]. Another study conducted among urban and rural pregnant women in Namibia showed an overall rubella seroprevalence of 85%, with urban women having higher risk of infection [24]. These differences in seroprevalence rates can be attributed to the degree of contamination at national level, the testing method used and/or the size of the sample used.…”

Section: Discussionmentioning

confidence: 99%

Rubella Seroprevalence and real-time PCR detection of RUBV among Congolese pregnant women

et al. 2017

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BackgroundRubella is an acute infectious disease caused by Rubella virus (RUBV). RUBV remains an important pathogen worldwide, causing approximately 100 000 cases of congenital rubella syndrome (CRS) every year; and the most severe consequence of rubella is teratogenicity. The aim of this study was to estimate the prevalence of RUBV IgG antibodies and determine RUBV genotypes in Congolese pregnant women in Kongo central province, Democratic Republic of Congo (DRC).MethodsThis was a prospective cross-sectional study that consisted of a laboratory analysis of blood samples from 78 pregnant women to check for the presence of RUBV IgG antibodies, and also determine RUBV genotypes in seropositive samples (using primers targeting RUBV nucleoprotein), with the use of serological and molecular methods, respectively. Participants were pregnant women attending antenatal care clinics (ANC) at two health zones of Kisantu town in DRC. They were followed-up from the first to third trimester. Those who were negative for RUBV antibodies at the initial assay (first trimester) were tested in the second and, eventually, the third trimester.ResultsAn overall rubella seroprevalence of 58.97% was observed, whereas RUBV nucleoprotein was detected in 60% of randomly selected 30 blood samples among the 46 RUBV seropositive pregnant women. Five (27.77%) of positive samples were positive for both RUBV genotypes (RV8633/9112 and RV8945/9577), whereas 11 (61.11%) of them were positive for RV8633/9112 and two (11.11%) were positive for RV8945/9577 only. Regarding rubella clinical signs and complications, two subjects (2.56%) presented with fever, whereas five pregnant women (6.41%) had experienced abortion. None (0%) of the participants has been vaccinated against RUBV.ConclusionsFindings from this study suggest that RUBV is prevalent in Congolese pregnant women. Further research is required to elucidate the molecular epidemiology of RUBV in order to design a rational rubella surveillance and control program in DRC.

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“…The main aims of vaccination programs are to prevent rubella infection during pregnancy and to protect CRS. The seroprevalence of rubella virus infection among pregnant women in several countries has been reported [ 16 – 21 ]. However, the rubella seroprevalence in Chinese pregnant women population has been scantily studied, only one report among Chinese women of reproductive age during preconception period were available to estimate the immune protection level and CRS risk in our country [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

Rubella seroprevalence among pregnant women in Beijing, China

Meng

Luo

et al. 2018

BMC Infect Dis

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BackgroundRubella infection in pregnant women can result in serious effects, such as miscarriages, stillbirths, and congenital rubella syndrome (CRS). However, very little is known about the rubella seroprevalence among pregnant women in China.MethodsThis is a cross-sectional and hospital-based study. From June 2016 through March 2017, a total of 324 serum samples from healthy pregnant women were collected in the Shunyi Women and Children’s Hospital of Beijing Children’s Hospital. Rubella-specific IgG antibody was determined by ELISA (Euroimmun, Lübeck, Germany) kits. International assigned cut-off values of ≥10 IU/ml were used to assess the percentage of pregnant women with protective IgG concentrations.ResultsThe total rate of protected individuals was 83.3% (95% CI: 78.9%–87.0%). The protective rates of pregnant women in 17–26 years group, 27–36 years group and 37–46 years group were 84.0% (95% CI: 75.3%–90.1%), 81.9% (95% CI: 74.9%–87.4%) and 84.9% (95% CI: 75.8%–90.9%) respectively. No significant difference in protective rates among the three age groups was found (P = 0.83). There were also no statistically significant correlations between protective rates and gravidity (P = 0.84), parity (P = 0.84), birth place (P = 0.16), residence area (P = 0.58), education (P = 0.40) or occupation (P = 0.65).ConclusionsDespite the generally low vaccination coverage for rubella, most of Chinese pregnant women had potent rubella immunity. However, at least 16.7% of pregnant women were susceptible to rubella, which suggested rubella immunization in Chinese women at or before child-bearing age.

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Rubella immunity among pregnant women aged 15–44 years, Namibia, 2010

Cited by 19 publications

References 29 publications

Rubella virus infections and immune status among pregnant women before the introduction of rubella vaccine in Amhara Regional State, Ethiopia

Rubella virus infections and immune status among pregnant women before the introduction of rubella vaccine in Amhara Regional State, Ethiopia

Rubella Seroprevalence and real-time PCR detection of RUBV among Congolese pregnant women

Rubella seroprevalence among pregnant women in Beijing, China

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