Rubella antibody among pregnant women in Hawaii

Sever, John L.; Fabiyi, A; McCallin, Paul F.; Chu, Philip; Weiss, William; Cilkeson, Mary Ruth

doi:10.1016/0002-9378(65)90735-0

Cited by 13 publications

(2 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Dudgeon et al [3] capital of Uganda. Further studies by Sever et al [13] showed that 60 % of 228 pregnant women in Hawaii had no antibody to rubella. Nagayama et al [9] found 35 % seronegative among 193 serum specimens from pregnant women 18-40 years of age in Fukuoka city and its suburbs in Southern Japan.…”

mentioning

confidence: 98%

Rubella Immunity as Related to Age and History of Overt Disease

et al. 1967

View full text Add to dashboard Cite

The development of tissue culture techniques for the cultivation of rubella virus and for the detection of neutralizing antibody in patients with rubella [lo, 181, followed by the demonstration that rubella could be transmitted only to subjects who did not have neutralizing antibody, individuals with pre-existing antibody being immune [l, 2, 5, 6, 11, 12, 161, made it possible to determine the frequency of susceptibility to rubella in different populations.Sever et al. [15] found that 18 % of 600 women 1 P 4 4 years old from different parts of the United States did not have neutralizing antibody against rubella virus, a higher incidence of susceptibility demonstrated in the negro (21 yo) than in the white women (14 %). A sample from Honolulu, Hawaii, revealed 44 % without antibody. The frequency of antibody was not significantly associated with histories of rubella. Dudgeon et al. [3] found 9 seronegative specimens among 50 cord bloods (18 %) from a London obstetric hospital and 6 seronegative among 25 cord bloods (24 %) from Kampala, the This study was supported by the Swedish Medical Research Council (Project No. 19x-762-01) and by the County Council of Sodermanlend. capital of Uganda. Further studies by Sever et al. [13] showed that 60 % of 228 pregnant women in Hawaii had no antibody to rubella. Nagayama et al. [9] found 35 % seronegative among 193 serum specimens from pregnant women 18-40 years of age in Fukuoka city and its suburbs in Southern Japan.Givan et al.[4] studied small groups of females of different age in Toronto, Canada, and found neutralizing rubella antibody in about 10 % of children up to 4 years increasing to about 80 Yo in those 35-40 years old. These tests were performed with a serum dilution of 1 : 6. It was also reported that the incidence of females with higher antibody levels (a titre of a t least 24) reached a peak of more than 50 % in the age group 15-19 years falling to 20 % in those 35-40 years old. Sever et al. [14] determined the frequency of antibody in serum specimens from 268 individuals in Montgomery County, Maryland, U.S.A., collected in 1957. The frequency of serological immunity increased from approximately 35 yo in children 1-10 years of age to 85 % in the group 16 years and older.

show abstract

mentioning

confidence: 98%

Rubella Immunity as Related to Age and History of Overt Disease

et al. 1967

View full text Add to dashboard Cite

show abstract

“…Seroepidemiologic studies demonstrated that in temperate climates, the rate of seropositivity increased with age, and among women of childbearing age, about 80 to 85% were immune (Hanshaw et aI., 1985). Lower seropositive rates, however, exist in certain tropical island populations such as Hawaii (Sever, 1965). Puerto Rico (Greenberg et aI., 1973), Trinidad, Jamaica, and Taiwan (Grayston et aI., 1972, Harcourt et aI., 1979.…”

Section: Epidemiologymentioning

confidence: 96%

Togaviridae: Rubella Virus

Best¹,

O’Shea²

1988

Laboratory Diagnosis of Infectious Diseases Principles and Practice

View full text Add to dashboard Cite

Disease: Rubella, congenital rubella. Etiologic Agent: Rubella virus, genus Rubivirus of Togaviridae. Clinical Manifestations: Asyptomatic infections are common; fever with rash; lymphadenitis; arthropathy and arthritis in adults. Congenital infection may result in fetal death and spontaneous abortion, live birth of severely malformed infant, an infant with minimal damage, or a healthy infant. Pathology: Primary site of virus replication is the nasopharyngeal mucosa, followed by spread of virus to local lymph nodes and a viremia 7 days after infection. The appearance of a rash may be caused by viral antigen-antibody complexes. During pregnancy, the virus infects the placenta and is then disseminated to all fetal tissues. Laboratory Diagnosis: IgG serology in paired serum specimens; IgM serology in a single serum. IgG serology is in large-scale use for immunity testing. Epidemiology: Worldwide distribution; endemic in temperate climates, with seasonal peaks during spring and early summer. In countries with successful childhood vaccination programs, major epidemics have been prevented.

show abstract

The Epidemiology of Rubella

Sever¹

1967

Archives of Ophthalmology

View full text Add to dashboard Cite

Rubella antibody among pregnant women in Hawaii

Cited by 13 publications

References 5 publications

Rubella Immunity as Related to Age and History of Overt Disease

Rubella Immunity as Related to Age and History of Overt Disease

Togaviridae: Rubella Virus

The Epidemiology of Rubella

Contact Info

Product

Resources

About