Objective: To compare the efficacy of injection sclerotherapy and rubber band ligation in patients with 2nd degreehaemorrhoids.Study design & Setting: Prospective Observational study was conducted in PNS Shifa Karachi from 1st July 2018 to31st March 2019.Methodology: A total of 240 patients of both genders, known cases of 2nd degree haemorrhoids were included in thestudy. Patients with a known history of liver cirrhosis, previous history of haemorrhoidectomy, severe anaemia uncontrolledhypertension and patient requiring additional intervention post-procedure were excluded. Patients were randomized toeither the injection sclerotherapy Group A or rubber band ligation Group B by lottery method. Final assessment was doneat 6-months post-procedure regarding the effect of treatment on rectal bleeding.Results: The age range in this study was from 18 to 65 years with a m e a n of 36.641±7.00 years in Group Awhile 35.700± 5.65 years in Group B. Mean BMI was 26.525±1.54 Kg/m2 in Group A and 26.316±1.48 Kg/m2 inGroup B and duration of disease was 7.466±2. 15 months in Group A and 7.883±1.78 months in Group B. Efficacywas seen in 87.5% patients in Group A as compared to 98.3% in Group B (p=0.001).Conclusion: Rubber band ligation is more efficacious in the management of 2nd-degree haemorrhoids in terms of perrectal bleeding from 3rd-week to 6 months post-application.