rTMS treatment for abrogating intracerebral hemorrhage‐induced brain parenchymal metabolite clearance dysfunction in male mice by regulating intracranial lymphatic drainage

Liu, Yuheng; Liu, Xuanhui; Sun, Pengju; Li, Jing; Nie, Meng; Gong, Jinlong; He, Anbang; Zhao, Mingyu; Yang, Chen; Wang, Zengguang

doi:10.1002/brb3.3062

Cited by 5 publications

(2 citation statements)

References 88 publications

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“…Ischemic and hemorrhagic strokes have also been investigated in terms of their effect on the glymphatic system [25,[34][35][36][37][38][39][40][41][42][43][44][45][46]. See Supplemental Table 2 for an overview of the 14 included articles spanning 10 animal and 4 human studies.…”

Section: Strokementioning

confidence: 99%

The glymphatic system for neurosurgeons: a scoping review

Al Masri,

Corell,

Michaëlsson

et al. 2024

Neurosurg Rev

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The discovery of the glymphatic system has revolutionized our understanding of cerebrospinal fluid (CSF) circulation and interstitial waste clearance in the brain. This scoping review aims to synthesize the current literature on the glymphatic system’s role in neurosurgical conditions and its potential as a therapeutic target. We conducted a comprehensive search in PubMed and Scopus databases for studies published between January 1, 2012, and October 31, 2023. Studies were selected based on their relevance to neurosurgical conditions and glymphatic function, with both animal and human studies included. Data extraction focused on the methods for quantifying glymphatic function and the main results. A total of 67 articles were included, covering conditions such as idiopathic normal pressure hydrocephalus (iNPH), idiopathic intracranial hypertension (IIH), subarachnoid hemorrhage (SAH), stroke, intracranial tumors, and traumatic brain injury (TBI). Significant glymphatic dysregulation was noted in iNPH and IIH, with evidence of impaired CSF dynamics and delayed clearance. SAH studies indicated glymphatic dysfunction with the potential therapeutic effects of nimodipine and tissue plasminogen activator. In stroke, alterations in glymphatic activity correlated with the extent of edema and neurological recovery. TBI studies highlighted the role of the glymphatic system in post-injury cognitive outcomes. Results indicate that the regulation of aquaporin-4 (AQP4) channels is a critical target for therapeutic intervention. The glymphatic system plays a critical role in the pathophysiology of various neurosurgical conditions, influencing brain edema and CSF dynamics. Targeting the regulation of AQP4 channels presents as a significant therapeutic strategy. Although promising, the translation of these findings into clinical practice requires further human studies. Future research should focus on establishing non-invasive biomarkers for glymphatic function and exploring the long-term effects of glymphatic dysfunction.

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Section: Strokementioning

confidence: 99%

The glymphatic system for neurosurgeons: a scoping review

Al Masri,

Corell,

Michaëlsson

et al. 2024

Neurosurg Rev

View full text Add to dashboard Cite

show abstract

“…In addition to using drugs or biologics, clearing obstructed glymphatic channels has also been achieved in animal models using mechanical methods such as focused ultrasound treatment in combination with microbubbles (FUS-MB) ( 122 ), and non-invasive neuronal stimulation techniques, such as transcranial magnetic stimulation (TMS) or multisensory stimulation ( 228 , 229 ). A recent study using the 5xFAD AD mouse model showed that treatment with FUS-MB led to enhanced solute Aβ clearance from the brain, first into the CSF space and then into the deep cervical lymph nodes, which correlated with improved memory functions ( 122 ).…”

Section: Considerations In the Study And Clinical Use Of Brain-border...mentioning

confidence: 99%

Emergence of the brain-border immune niches and their contribution to the development of neurodegenerative diseases

Tan,

Cunliffe,

Hogan

et al. 2024

Front. Immunol.

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Historically, the central nervous system (CNS) was regarded as ‘immune-privileged’, possessing its own distinct immune cell population. This immune privilege was thought to be established by a tight blood-brain barrier (BBB) and blood-cerebrospinal-fluid barrier (BCSFB), which prevented the crossing of peripheral immune cells and their secreted factors into the CNS parenchyma. However, recent studies have revealed the presence of peripheral immune cells in proximity to various brain-border niches such as the choroid plexus, cranial bone marrow (CBM), meninges, and perivascular spaces. Furthermore, emerging evidence suggests that peripheral immune cells may be able to infiltrate the brain through these sites and play significant roles in driving neuronal cell death and pathology progression in neurodegenerative disease. Thus, in this review, we explore how the brain-border immune niches may contribute to the pathogenesis of neurodegenerative disorders such as Alzheimer’s disease (AD), Parkinson’s disease (PD), and multiple sclerosis (MS). We then discuss several emerging options for harnessing the neuroimmune potential of these niches to improve the prognosis and treatment of these debilitative disorders using novel insights from recent studies.

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rTMS treatment for abrogating intracerebral hemorrhage‐induced brain parenchymal metabolite clearance dysfunction in male mice by regulating intracranial lymphatic drainage

Liu

Sun

et al. 2023

Brain and Behavior

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Background The discovery of the glymphatic system and meningeal lymphatic vessels challenged the traditional view regarding the lack of a lymphatic system in the central nervous system. It is now known that the intracranial lymphatic system plays an important role in fluid transport, macromolecule uptake, and immune cell trafficking. Studies have also shown that the function of the intracranial lymphatic system is significantly associated with neurological diseases; for example, an impaired intracranial lymphatic system can lead to Tau deposition and an increased lymphocyte count in the brain tissue of mice with subarachnoid hemorrhage. Methods In this study, we assessed the changes in the intracranial lymphatic system after intracerebral hemorrhage and the regulatory effects of repeated transcranial magnetic stimulation on the glymphatic system and meningeal lymphatic vessels in an intracerebral hemorrhage (ICH) model of male mice. Experimental mice were divided into three groups: Sham, ICH, and ICH + repeated transcranial magnetic stimulation (rTMS). Three days after ICH, mice in the ICH+rTMS group were subjected to rTMS daily for 7 days. Thereafter, the function of the intracranial lymphatic system, clearance of RITC‐dextran and FITC‐dextran, and neurological functions were evaluated. Results Compared with the Sham group, the ICH group had an impaired glymphatic system. Importantly, rTMS treatment could improve intracranial lymphatic system function as well as behavioral functions and enhance the clearance of parenchymal RITC‐dextran and FITC‐dextran after ICH. Conclusion Our results indicate that rTMS can abrogate ICH‐induced brain parenchymal metabolite clearance dysfunction by regulating intracranial lymphatic drainage.

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rTMS treatment for abrogating intracerebral hemorrhage‐induced brain parenchymal metabolite clearance dysfunction in male mice by regulating intracranial lymphatic drainage

Cited by 5 publications

References 88 publications

The glymphatic system for neurosurgeons: a scoping review

The glymphatic system for neurosurgeons: a scoping review

Emergence of the brain-border immune niches and their contribution to the development of neurodegenerative diseases

rTMS treatment for abrogating intracerebral hemorrhage‐induced brain parenchymal metabolite clearance dysfunction in male mice by regulating intracranial lymphatic drainage

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