RSM based engineering of the critical gelation temperature in magneto-thermally responsive nanocarriers

Khodaei, Azin; Bagheri, Reza; Hosseini, Hamid Reza Madaah; Bagherzadeh, Elham

doi:10.1016/j.eurpolymj.2019.08.024

Cited by 9 publications

(8 citation statements)

References 30 publications

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“…With the temperature elevation going on, even the PEO groups dehydrated, and the hydrophobicity increased [ 52 ]. Although earlier studies on sol-gel transition in pluronic showed that this transition is non-kinetic and happens all in the LCST, the concentration of the released drug here is not step-like but bell-like [ 33 , 53 ]. This finding is explained by the high affinity of hydrophobic aromatic rings in curcumin to the pluronic gel, which prevents the release of curcumin from the carrier [ 54 ].…”

Section: Resultsmentioning

confidence: 98%

“…1 d). The coating of OA-F127/F68 on the surface was discussed before [ 33 ]. The main specific peak of pluronic is C–O–C stretching vibrations peak at 1100 cm −1 .…”

Section: Resultsmentioning

confidence: 99%

“…According to the previously extracted model by our group, the parameters in the synthesis protocol of magnetic nanocarriers were selected to adjust the LCST around 45 °C [ 33 ]. Coating of nanoparticles was applied using 14.5 ml oleic acid (Sigma) per gram of particles, polymer/particle ratio of 12.5, and F127/F68 (Sigma) ratio of 1.5.…”

Section: Methodsmentioning

confidence: 99%

“…Thus, combining “mild hyperthermia” [ 32 ] with controlled release of novel drugs to provide a synergistic effect in the eradication of the tumor cells should be seriously considered. In our previous work [ 33 ] we have reported the blend formulation of Pluronic F127, and F68 on the oleic acid coated SPION to model lower critical solution temperature (LCST), however the release study and optimization of the electromagnetic field according to its bio-functionality were remained unexplored [ 33 ]. Here, we used the aforementioned nanocarrier for curcumin delivery triggered by mild hyperthermia.…”

Section: Introductionmentioning

confidence: 99%

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Controlled temperature-mediated curcumin release from magneto-thermal nanocarriers to kill bone tumors

Khodaei

Jahanmard

Hosseini

et al. 2022

Bioactive Materials

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Systemic chemotherapy has lost its position to treat cancer over the past years mainly due to drug resistance, side effects, and limited survival ratio. Among a plethora of local drug delivery systems to solve this issue, the combinatorial strategy of chemo-hyperthermia has recently received attention. Herein we developed a magneto-thermal nanocarrier consisted of superparamagnetic iron oxide nanoparticles (SPIONs) coated by a blend formulation of a three-block copolymer Pluronic F127 and F68 on the oleic acid (OA) in which Curcumin as a natural and chemical anti-cancer agent was loaded. The subsequent nanocarrier SPION@OA-F127/F68-Cur was designed with a controlled gelation temperature of the shell, which could consequently control the release of curcumin. The release was systematically studied as a function of temperature and pH, via response surface methodology (RSM). The bone tumor killing efficacy of the released curcumin from the carrier in combination with the hyperthermia was studied on MG-63 osteosarcoma cells through Alamar blue assay, live-dead staining and apoptosis caspase 3/7 activation kit. It was found that the shrinkage of the F127/F68 layer stimulated by elevated temperature in an alternative magnetic field caused the curcumin release. Although the maximum release concentration and cell death took place at 45 °C, treatment at 41 °C was chosen as the optimum condition due to considerable cell apoptosis and lower side effects of mild hyperthermia. The cell metabolic activity results confirmed the synergistic effects of curcumin and hyperthermia in killing MG-63 osteosarcoma cells.

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Section: Resultsmentioning

confidence: 98%

“…1 d). The coating of OA-F127/F68 on the surface was discussed before [ 33 ]. The main specific peak of pluronic is C–O–C stretching vibrations peak at 1100 cm −1 .…”

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Controlled temperature-mediated curcumin release from magneto-thermal nanocarriers to kill bone tumors

Khodaei

Jahanmard

Hosseini

et al. 2022

Bioactive Materials

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“…The inflection point of temperature at this time was called the critical gel temperature. [ 49 ] The results showed that these three types of bio‐inks reached the gel point at 22–25 ℃. According to the measured value, it can be set as the temperature reference range for the printer cartridge, so as to ensure the printing forming of the bio‐ink.…”

Section: Resultsmentioning

confidence: 99%

3D Printing for Biological Scaffolds using Poly(Ionic Liquid)/Gelatin/Sodium Alginate Ink

Zhang

Wang

et al. 2021

Macro Materials & Eng

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The poly(ionic liquid)s (PILs) have attracted a wide range of applications in thermo‐responsive materials, carbon materials, catalysis, porous polymers, separation and absorption materials, and biological field due to their favorable tunability and biological functions. However, the applications of PILs in bio‐scaffold are rarely studied. In the present work, the ionic liquid (IL) monomer (1‐vinyl‐3‐butylimidazolium chloride, [VBIM]Cl) is cross‐linked with other three compounds, respectively, to synthesize three kinds of PILs (PIL1, PIL2, and PIL3). Furthermore, individually cross‐linked PILs are added into gelatin (Gel)/sodium alginate (SA) solution aiming to prepare biological inks (bio‐inks) for 3D printing. The water absorption, degradation rate, and porosity of the bio‐scaffolds are measured to evaluate the physicochemical characteristics, while the PC12 cell line is used to evaluate the biocompatibility of the bio‐scaffolds through cell proliferation. These results demonstrate that the biological activity of the bio‐scaffold can be varied at the tendency of PIL1 < PIL3 < PIL2, providing a potential prospect for the application of PILs in tissue‐engineered bio‐scaffolds.

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Improved water flux in optimized electrospun polysulfone/nanoclay membranes

2022

Self Cite

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Water crisis is undoubtedly one of the main global challenges and water membranes can be used to tackle this issue. In this study, electrospun polysulfone (PSU)/nanoclay membranes were fabricated. The fabrication process was optimized to achieve desirable fibers using response surface methodology, considering nanoclay concentration, electrospinning feeding rate, and voltage as the influencing factors on the membrane properties. SEM images was used to determine the average fiber diameter and imperfection factor of the fibrous composites and their hydrophilicity was assessed based on their water contact angle (CA) values. A suitable model was proposed for each property to predict its variation with the influencing parameters. The results showed that the voltage and feed rate are directly related to the average fiber diameter and CA of the membranes. Moreover, introducing hydrophilic nanoclay to the membranes improved their wettability. The optimum properties were achieved in the membrane containing 5.63 wt% nanoclay, which was electrospun at a feed rate and voltage of 0.7 mL/h, and 16 kV, respectively. Comparing the mechanical properties and water flux performance of pure PSU membranes with the optimal sample confirmed that the presence of nanoclay improved the mechanical strength and toughness of the membranes and enhanced the attainable water flux.

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RSM based engineering of the critical gelation temperature in magneto-thermally responsive nanocarriers

Cited by 9 publications

References 30 publications

Controlled temperature-mediated curcumin release from magneto-thermal nanocarriers to kill bone tumors

Controlled temperature-mediated curcumin release from magneto-thermal nanocarriers to kill bone tumors

3D Printing for Biological Scaffolds using Poly(Ionic Liquid)/Gelatin/Sodium Alginate Ink

Improved water flux in optimized electrospun polysulfone/nanoclay membranes

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