Rs12218 In SAA1 gene was associated with serum lipid levels

Xu, Xiaolin; Sun, Xiaotian; Pang, Liewen; Huang, Guoqiang; Shi, Meng; Wang, Yiqing

doi:10.1186/1476-511x-12-116

Cited by 6 publications

(5 citation statements)

References 17 publications

(24 reference statements)

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“…Regarding our study, we found that variation in SAA gene (rs12218) was significantly associated with the plasma level of total cholesterol, TG, HDLc and LDLc levels in the osteoporosis patients, these results comes on line with Zheng et al 14 & Xie et al 20 …”

Section: Discussionsupporting

confidence: 89%

Serum Amyloid A Gene polymorphism and its association with lipid profile in Saudi Females with osteoporosis

2015

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Background and Objective:Osteoporosis can be defined as a systemic skeletal disease characterized by low bone mass and micro architectural decline of bone tissue. Serum amyloid A (SAA) is a family of protein that increases up to 1,000-fold in blood during inflammation. In this study, we aimed to study the relationship between SAA1 gene polymorphism (rs12218) and lipid profile and osteoporosis.Methods:The study was performed on the female students of Taibah University in Al Medina, KSA during June 2014 to April 2015. According to BMD; osteoporosis group (138 students) and control group (128 students). All groups were subjected to; BMI, BMD, calcium, phosphorus, creatinine, lipid profile and SAA. Polymerase chain reaction and Real Time were done to determine the distribution of allele and genotype frequency of SAA (rs12218) C/T polymorphism.Results:This study shows that the TT genotype of rs12218 was more frequent in osteoporosis group than control group (P<0.001). Also, TT genotype and T allel was found to be associated with plasma total cholesterol, TG, LDLc, HDLc, Tscore, Zscore and SAA1 level in osteoporosis group (P=0.000, P=0.05, and P=0.000, P=0.000, P=0.01, P=0.02, P=0.000 respectively). The logistic regression analysis with and without lipid disorders in the osteoporosis group also show that the TT genotype of rs12218 still differed significantly between these two groups (P=0.001, OR=1.814, 95% CI: 0.719-4.577).Conclusion:The results of this study shows a significant association between TT genotype of rs12218 and both lipid level and osteoporosis in Saudi female population.

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Section: Discussionsupporting

confidence: 89%

Serum Amyloid A Gene polymorphism and its association with lipid profile in Saudi Females with osteoporosis

2015

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“…As described previously [ 18 , 20 ], SAA1 encodes one important inflammation factor-SAA.. Recently, Xie et al reported that rs12218 polymorphism in SAA1 gene was associated with IMT [ 17 ], HDL-C [ 18 , 19 ], Ankle-brachial index (ABI) [ 20 ], and plasma uric acid levels [ 18 ] which was related to cardiovascular disease in adults. And Zhang et al reported SAA1 gene polymorphism was associated with cerebral infarction [ 21 ].…”

Section: Resultsmentioning

confidence: 98%

“…And Zhang et al reported SAA1 gene polymorphism was associated with cerebral infarction [ 21 ]. Xu et al also reported SAA1 gene polymorphism was associated with lipid levels [ 19 ]. However, the relationship between SAA gene polymorphism and obesity in Children remains unclear.…”

Section: Resultsmentioning

confidence: 99%

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SAA1 gene variants and childhood obesity in China

et al. 2013

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BackgroundObesity increases the risk for insulin resistance and metabolic syndrome in both adults and children. SAA is a member of apolipoprotein and plays an important role in maintaining glucose and lipid homeostasis. The purpose of this study was to assess SAA1 allelic variants with obesity in young school-age children.MethodsA total of 520 consecutive children ages 5–15 years were recruited. Children were divided based on BMI z score into Obese (OB; BMI z score ≥1.65; n = 253) and non-obese (NOB; n = 267). Four SNPs of the human SAA1 gene (rs12218, rs4638289, rs7131332 and rs11603089) were genotyped by use of polymerase chain reaction – restriction fragment length polymorphism (PCR-RFLP) method.ResultsCompared to NOB, circulating SAA levels were increased in OB, as were LDL-C, TG and TC concentration. Obese children showed increased frequency of rs12218 and rs4638289 polymorphism compared to control children. There were no differences between OB and NOB for the other 2 polymorphisms. Only the rs4638289 polymorphism showed significant contributions to higher SAA plasma levels.ConclusionsSAA1 genetic polymorphism was associated with obesity in Chinese children.

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“…Of particular interest is the finding that synonymous codon changes resulting from SAA1 SNPs ( e.g. , rs12218), which does not lead to amino acid substitution, has been associated with several diseases including increased serum uric acid level and increased body weight (Xu et al, 2013). How this type of SNPs affects SAA1 function remains unclear, but it may be related to altered SAA1 expression level.…”

Section: Discussionmentioning

confidence: 99%

Serum amyloid A1 isoforms display different efficacy at Toll-like receptor 2 and formyl peptide receptor 2

et al. 2014

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Serum amyloid A (SAA) is a major acute-phase protein and a precursor of amyloid A, the deposit of which leads to amyloidosis. Different alleles exist in SAA1, a predominant form of the human SAA gene family. Emerging evidence has shown correlations between these alleles and diseases including familiar Mediterranean fever and amyloidosis. However, it remains unclear how the proteins encoded by these SAA1 alleles act differently. Here we report the characterization of proteins encoded by SAA1.1, SAA1.3 and SAA1.5, in comparison to that encoded by SAA2.2, for their preference of the SAA receptors including formyl peptide receptor 2 (FPR2) and Toll-like receptor 2 (TLR2). SAA1.1 was more efficacious than SAA1.3 and SAA1.5 but equally efficacious to SAA2.2 in calcium mobilization and chemotaxis assays, which measure the activation of the G protein-coupled FPR2. In agreement with this, SAA1.1 and SAA2.2 induced more robust phosphorylation of ERK than SAA1.3 and SAA1.5. Only small differences were observed between the SAA1 proteins tested and SAA2.2 in TLR2-dependent NF-κB luciferase reporter assay. In comparison, SAA1.3 was most effective in stimulating ERK and p38 MAPK phosphorylation. Using bone marrow-derived macrophages from C57BL/10ScN (Tlr4lps-del) mice, we examined the SAA isoforms for their induction of selected pro- and anti-inflammatory cytokines. SAA1.3 was most potent in the induction of TNFα and IL-1rn, whereas SAA1.5 induced robust IL-10 expression. These results show differences of the SAA1 isoforms in their selectivity for the SAA receptors, which may affect their roles in modulating inflammation and immunity.

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Rs12218 In SAA1 gene was associated with serum lipid levels

Cited by 6 publications

References 17 publications

Serum Amyloid A Gene polymorphism and its association with lipid profile in Saudi Females with osteoporosis

Serum Amyloid A Gene polymorphism and its association with lipid profile in Saudi Females with osteoporosis

SAA1 gene variants and childhood obesity in China

Serum amyloid A1 isoforms display different efficacy at Toll-like receptor 2 and formyl peptide receptor 2

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