Rs10887800 renalase gene polymorphism is associated with an increased risk of coronary artery disease in hemodialyzed patients

Steć, Anna; Książek, Andrzej; Buraczyńska, Monika

doi:10.1007/s11255-016-1270-7

Cited by 18 publications

(26 citation statements)

References 21 publications

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“…Our recent studies of HD population have demonstrated the association between RNLS gene polymorphisms and the increased risk of cardiovascular diseases [8, 9], but the exact mechanism underlying this link has remained unknown. On the basis of current findings we presume that rs10887800 polymorphism of RNLS gene can modify the risk of different human diseases due to modulation of plasma RNLS level.…”

Section: Discussionmentioning

confidence: 99%

“…The renalase gene ( RNLS ) is positioned on chromosome 10 (10q23.31), has 13 exons and several polymorphic variants [7]. The recent studies on hemodialyzed population have revealed that single nucleotide polymorphisms (SNPs) of RNLS gene affect the risk of cardiovascular conditions such as arterial hypertension (HY) or coronary artery disease (CAD) [8, 9]. However, the exact mechanism underlying the functional interplay between those pathologies and RNLS genetic variants remains unknown.…”

Section: Introductionmentioning

confidence: 99%

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Rs10887800 renalase gene polymorphism influences the level of circulating renalase in patients undergoing hemodialysis but not in healthy controls

Steć

2017

BMC Nephrol

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BackgroundHuman renalase (RNLS), a recently identified flavoprotein with oxidoreductase activity, is secreted into blood by kidneys and metabolizes circulating catecholamines. Recent studies have revealed that common polymorphisms in RNLS gene might affect the risk of several cardiovascular conditions in hemodialyzed patients. However, the exact mechanism underlying this link remains unclear. The study aims to investigate the association between RNLS gene polymorphisms and plasma renalase level in ESKD patients undergoing hemodialysis (HD group) and healthy controls (HC).MethodsA total of 309 hemodialyzed patients and 90 controls were enrolled in the study. All the participants were genotyped for two RNLS SNPs (rs2576178 and rs10887800) using PCR-RFLP method. Plasma renalase concentrations were determined by enzyme-linked immunosorbent assay (USCN Life Science Inc., Wuhan, China). The IBM SPSS Statistics for Windows, version 20 (IBM Corp., Armonk, NY, USA) was used for statistical analyses.ResultsGenotype distribution and allele frequencies of studied SNPs did not differ between two analyzed groups, p > .050. RNLS concentration in HD group (33.54 μg/mL) was significantly higher than in HC (13.16 μg/mL), p < .001. HD patients with rs10887800AA genotype had lower renalase level (29.32 μg/mL) compared to those with AG (34.52 μg/mL), p < .010 and GG genotype (35.91 μg/mL), p < .010. No significant differences in plasma RNLS between rs10887800AG and GG carriers were observed, p > .050. Interestingly, in HC group rs10887800 polymorphism did not influence RNLS concentration. Rs2576178 SNP did not affect the level of plasma RNLS either in HD group or in HC.ConclusionRs10887800 polymorphic variant of RNLS gene influences the level of circulating RNLS in patients undergoing hemodialysis, and thus elucidates the potentially functional relevance of this polymorphism in HD population.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Rs10887800 renalase gene polymorphism influences the level of circulating renalase in patients undergoing hemodialysis but not in healthy controls

Steć

2017

BMC Nephrol

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“…Researchers suggested, that listed polymorphisms are of negligible importance, at least in that population [37]. A recent study by Stec et al [38] on 309 haemodialysed patients (107 with and 202 without CAD genotyped for two SNPs in the renalase gene [rs10887800 and rs2576178]) rs10887800GG genotype was associated with an increased risk of CAD whereas rs2576178 polymorphism did not influence the risk of CAD. The authors concluded that rs10887800 renalase gene polymorphism could be considered a new genetic risk factor for CAD in this population.…”

Section: Renalase and Cvdmentioning

confidence: 99%

Renalase — a new marker or just a bystander in cardiovascular disease: clinical and experimental data

Musiałowska

Małyszko

2016

Kardiol Pol

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“…Renalase gene RNLS resides on chromosome 10 (10q23.31). Stec et al [11] investigate the association between rs10887800 and rs2576178 renalase gene polymorphisms and risk of coronary artery disease (CAD) in HD patients. The authors [11] observed that rs10887800 renalase gene polymorphism significantly increased the risk of CAD in HD.…”

Section: Introductionmentioning

confidence: 99%

“…Stec et al [11] investigate the association between rs10887800 and rs2576178 renalase gene polymorphisms and risk of coronary artery disease (CAD) in HD patients. The authors [11] observed that rs10887800 renalase gene polymorphism significantly increased the risk of CAD in HD. Moreover, the rs10887800 polymorphism affected the CAD risk independently of age, gender and other CAD risk factors, including smoking, BMI, hyperlipidemia, arterial hypertension and diabetes mellitus.…”

Section: Introductionmentioning

confidence: 99%

Levels of renalase and advanced oxidation protein products with regard to catecholamines in haemodialysed patients

Dziedzic

Orłowska

Petkowicz

et al. 2017

Ann Agric Environ Med.

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M. Levels of renalase and advanced oxidation protein products with regard to catecholamines in haemodialysed patients. Ann Agri Environ Med. 2017; 24(3): 453-458. doi: 10.5604/12321966.1233567 Abstract Introduction. The main mediators of the sympathetic nervous system in the effectors part are catecholamines (CA). An increased sympathetic nerve activity observed in chronic kidney disease (CKD), is due to a raised level of CA in plasma. Renalase is a protein secreted by the kidneys, composed of 342 amino acids, which is able to metabolize the circulating CA and possibly play an important role in the regulation of sympathetic tone and blood pressure. Also, oxidative stress, defined as a disruption of the equilibrium between the generation of oxidants, is a crucial factor in the development of the inflammatory syndrome associated with CKD. The advanced oxidation protein products (AOPP) represent exquisite markers of phagocyte-derived oxidative stress. Objective. The aim of the study was to investigate the concentration of renalase and explore the associations between AOPP with regards to CA in haemodialysis (HD) patients. Materials and method. The study was conducted among 50 residents of the municipality and neighbouring villages in the province of Lublin, central-eastern Poland. Results. In the studied patients, it was found that an average concentration of renalase was 44.8 ± 6.5 µg/mL, whereas of AOPP plasma levels -57.5 ± 21.5 µmol/L. The results demonstrated the correlation between levels of renalase and AOPP in the HD patients. Indeed, elevated levels of renalase and AOPP in HD may be due to the presence of uremic toxins in blood. The concentration of urea affects the plasma concentrations of AOPP and renalase causing a direct relationship between renalase and AOPP. However, there is no clear relationship between renalase and circulating catecholamines in HD patients.

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Rs10887800 renalase gene polymorphism is associated with an increased risk of coronary artery disease in hemodialyzed patients

Cited by 18 publications

References 21 publications

Rs10887800 renalase gene polymorphism influences the level of circulating renalase in patients undergoing hemodialysis but not in healthy controls

Rs10887800 renalase gene polymorphism influences the level of circulating renalase in patients undergoing hemodialysis but not in healthy controls

Renalase — a new marker or just a bystander in cardiovascular disease: clinical and experimental data

Levels of renalase and advanced oxidation protein products with regard to catecholamines in haemodialysed patients

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