Rs10887800 renalase gene polymorphism influences the level of circulating renalase in patients undergoing hemodialysis but not in healthy controls

Steć, Anna

doi:10.1186/s12882-017-0543-4

Cited by 10 publications

(11 citation statements)

References 26 publications

(29 reference statements)

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“…However, similar associations were not observed in CAD+ subgroup. Therefore, we can assume that the impact of rs10887800 variant on plasma RNLS level, previously reported by us in patients undergoing HD, was due to high prevalence of hypertensive participants in the study cohort [9].…”

Section: Disscusionmentioning

confidence: 64%

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Effect of renalase (RNLS) gene polymorphisms (rs1088700 and rs2576178) on plasma RNLS level in hemodialyzed patients affected by arterial hypertension and coronary artery disease

Steć

2017

Polish Journal of Public Health

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Introduction.We have previously reported that rs10887800 and rs2576178 renalase (RNLS) single nucleotide polymorphisms (SNPs) are associated with the susceptibility to arterial hypertension (HY) and coronary artery disease (CAD) in hemodialyzed patients (HD). However, the underlying mechanism of this link remains undefined.Aim. In the present study we examine the influence of above-mentioned RNLS gene variants on plasma renalase level in subgroups of HD patients affected by HY and CAD.Material and methods. In total, 309 hemodialyzed patients participated in the study (157 males and 152 females, mean age 64.1±14.10 years). Rs10887800 and rs2576178 RNLS gene polymorphisms were genotyped using PCR-RFLP method. Plasma RNLS level was assessed by ELISA (USCN Life Science Inc., Wuhan, China). The data were analyzed using SPSS Statistics 23.Results. Regarding rs10887800 polymorphism, hypertensive AA homozygotes had significantly lower plasma RNLS level (28.93±9.94 µg/mL) compared to AG (34.06±12.79 µg/mL) and GG carriers (36.54±12.01 µg/mL), p=0.002. Among CAD patients no differences in plasma RNLS concentrations between rs10887800AA, AG and GG carriers were observed (31.52±10.95 µg/mL, 34.75±13.37 µg/mL, 34.44±13.10 µg/mL, respectively), p=0.615. For the rs2576178 variant, both HY and CAD participants did not differ in terms of plasma RNLS levels with regard to the particular genotypes, p>0.050.Conclusion. Obtained results extend our previous findings and indicate for the first time that rs10887800 RNLS gene variant modifies the level of plasma RNLS in hemodialyzed patients with HY but not in those with CAD. The study provides, thus, a new insight into the potential mechanisms through which RNLS gene variants modulate the risk of cardiovascular diseases among patients with end-stage kidney disease.

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Section: Disscusionmentioning

confidence: 64%

“…The presence of residual renal function (RRF) was defined as the urine amount above 100 ml/day. The results of plasma RNLS level, genotype distribution and allele frequencies of rs10887800 and rs2576178 RNLS SNPs were taken from our previous studies [7,9]. All participants signed an Informed Consent Form.…”

Section: Introductionmentioning

confidence: 99%

Effect of renalase (RNLS) gene polymorphisms (rs1088700 and rs2576178) on plasma RNLS level in hemodialyzed patients affected by arterial hypertension and coronary artery disease

Steć

2017

Polish Journal of Public Health

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“…Elevated serum renalase was observed in homozygous genotype compared to wild type and heterozygous mutant for rs10887800 and rs2576178 polymorphisms. In contrast, an earlier report highlighted the association of elevated renalase levels in the GG genotype of rs10887800 compared to AA genotype and nonexistence of the relationship between rs2576178 polymorphism and plasma renalase levels in patients undergoing hemodialysis [29]. Also, an earlier report showed an association of high SBP and DBP with GG genotype of rs10887800 polymorphism and for GG genotype of rs2576178 only with SBP.…”

Section: Discussionmentioning

confidence: 86%

Renalase levels and genetic variants are associated with preeclampsia: a hospital based study in Chinese cohort

Li¹,

Huang²,

2020

Preprint

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Background Pre-eclampsia (PE) is a major contributor of maternal and fetal morbidity and mortality. There are many host related biomolecules that regulate the pathophysiology PE. Critical analysis of these parameters is of crucial importance as some of these may be used as prognostic/diagnostic marker of this serious ailment and can be targeted for developing therapeutic measures against the disease. The aim of the current study is to examine the role of renalse in the context PE in a Chinese cohort. Methods A hospital based case control study was designed to investigate role of renalase in PE. 384 Chinese women consisting of subjects with normotensive pregnancy (n = 105), women with PE (n = 121) and healthy pregnancy (n = 158) were included in the study. Serum renalse level was measured in recruited subjects by ELISA. Renalase gene polymorphisms (rs10887800, rs2576178 and rs2296545) were genotyped by PCR-RFLP. Results A higher level of serum renalse in healthy pregnant women compared to controls, whereas, subjects with PE demonstrated a reduced level of this enzyme. Renalse level was negatively correlated with systolic as well as diastolic blood pressure, whereas, a positive association was observed with glomerular filtration rate. Prevalence of homozygous mutant (GG) and minor allele (G) of rs10887800 and rs2576178 polymorphisms were higher in PE patients compared to normotensive pregnant women and healthy controls. Furthermore, association of G-G-C haplotype with susceptibility to PE was observed. Conclusions Low level of renalse may be associated with high risk of PE during pregnancy. Renalase gene polymorphisms (rs10887800 and rs2576178) are correlated with with serum renalase and associated with predisposition to development of PE in Chinese cohort.

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“… 14 , 28 Different SNPs including rs10887800, rs2576178, rs2296545 and rs2114406 are present in the RNLS gene, and their association with hypertensive, vascular, diabetes, and stroke has been the focus of many studies. 29 – 31 Even though the RNLS rs10887800 polymorphism was investigated under various conditions and in different population groups, the specific mechanism through which polymorphism altered the risk of USAP and MetS remains unspecified. The renalase rs10887800 examined by SNP is placed close to the exon/intron boundary in a putative functional region.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, it is possible that it influenced gene regulation and expression, leading to changes in the amount of renalase levels. 31 , 32…”

Section: Discussionmentioning

confidence: 99%

<p>Association of Serum Renalase Levels and Renalase rs10887800 Polymorphism with Unstable Angina Pectoris Patients Having Metabolic Syndrome</p>

Izadpanah

Asadian

Jangjou

2020

DMSO

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Purpose An increased risk of cardiovascular mortality and morbidity has been linked with metabolic syndrome (MetS), described as the secondary risk reduction target. These patients are predisposed to high complication levels such as unstable angina-pectoris (USAP) by MetS. As with the role of renalase in the regulation of blood pressure (BP), the study was carried out to determine the levels of renalase circulation in patients with USAP and MetS (USAP+MetS), as well as the association of renalase gene ( RNLS ) rs10887800 polymorphism and USAP and MetS susceptibility. Patients and Methods A total of 134 patients with USAP+MetS and 134 control subjects were recruited in this case-control study. Results Renalase was found to have a significantly higher level in USAP+MetS patients (23.28 ± 4.09 µg/dL) than in healthy ones (20.81 ± 2.73 µg/dL) (P < 0.001). Also, it was shown that renalase sensitivity and specificity values for the early diagnosis of USAP and MetS seemed to be 53.7% and 76.9, respectively. Moreover, the value for renalase area under curve (AUC) was 0.654 (95% CI: 0.58–0.72). The frequency of rs10887800 AG and GG genotypes of RNLS gene was significantly higher in USAP+MetS patients than in control subjects, suggesting that this genotype might be a risk factor against USAP+MetS (OR = 2.114 [95% CI 1.113–4.016]; P = 0.022) and (OR = 2.057 [95% CI 1.011–4.186]; P = 0.047), respectively. Conclusion The present results showed that renalase serum levels increased in USAP and MetS patients. Moreover, the RNLS rs10887800 was reported to be associated with a higher risk of USAP+MetS.

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Rs10887800 renalase gene polymorphism influences the level of circulating renalase in patients undergoing hemodialysis but not in healthy controls

Cited by 10 publications

References 26 publications

Effect of renalase (RNLS) gene polymorphisms (rs1088700 and rs2576178) on plasma RNLS level in hemodialyzed patients affected by arterial hypertension and coronary artery disease

Effect of renalase (RNLS) gene polymorphisms (rs1088700 and rs2576178) on plasma RNLS level in hemodialyzed patients affected by arterial hypertension and coronary artery disease

Renalase levels and genetic variants are associated with preeclampsia: a hospital based study in Chinese cohort

<p>Association of Serum Renalase Levels and Renalase rs10887800 Polymorphism with Unstable Angina Pectoris Patients Having Metabolic Syndrome</p>

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