Abstract:SUMMARYEnvenoming syndrome from Africanized bee stings is a toxic syndrome caused by the inoculation of large amounts of venom from multiple bee stings, generally more than five hundred. The incidence of severe toxicity from Africanized bee stings is rare but deadly. This report reveals that because of the small volume of distribution, having fewer stings does not exempt a patient from experiencing an unfavorable outcome, particularly in children, elderly people or underweight people.
“…Bee venom is a complex mixture of amines and peptides, most notably mellitin, the main and most toxic compound and phospholipase A2, the most immunogenic peptide [2,7]. In addition to causing the pain associated with bee stings, mellitin functions as a lytic peptide that destroys cells and leads to intravascular hemolysis [7,10]. Manifestations of envenoming syndrome include rhabdomyolysis, AKI, myocardial necrosis and infarction, disseminated intravascular coagulation, seizures, stroke, thrombocytopenia, and centrilobular necrosis of the liver [2,6,10,11].…”
Section: Discussionmentioning
confidence: 99%
“…In addition to causing the pain associated with bee stings, mellitin functions as a lytic peptide that destroys cells and leads to intravascular hemolysis [7,10]. Manifestations of envenoming syndrome include rhabdomyolysis, AKI, myocardial necrosis and infarction, disseminated intravascular coagulation, seizures, stroke, thrombocytopenia, and centrilobular necrosis of the liver [2,6,10,11]. Mortality from massive envenomation is often due to cardiac arrest or renal failure [11,12].…”
Envenoming syndrome is an uncommon condition associated with significant morbidity and mortality following multiple Hymenoptera stings. We review the case of a 90-year-old male who presented after receiving greater than 100 bee stings and was found to have rhabdomyolysis with concomitant acute kidney injury. Physicians should consider envenoming syndrome in all patients presenting with greater than 50 bee stings, despite hemodynamically stability upon initial presentation.
“…Bee venom is a complex mixture of amines and peptides, most notably mellitin, the main and most toxic compound and phospholipase A2, the most immunogenic peptide [2,7]. In addition to causing the pain associated with bee stings, mellitin functions as a lytic peptide that destroys cells and leads to intravascular hemolysis [7,10]. Manifestations of envenoming syndrome include rhabdomyolysis, AKI, myocardial necrosis and infarction, disseminated intravascular coagulation, seizures, stroke, thrombocytopenia, and centrilobular necrosis of the liver [2,6,10,11].…”
Section: Discussionmentioning
confidence: 99%
“…In addition to causing the pain associated with bee stings, mellitin functions as a lytic peptide that destroys cells and leads to intravascular hemolysis [7,10]. Manifestations of envenoming syndrome include rhabdomyolysis, AKI, myocardial necrosis and infarction, disseminated intravascular coagulation, seizures, stroke, thrombocytopenia, and centrilobular necrosis of the liver [2,6,10,11]. Mortality from massive envenomation is often due to cardiac arrest or renal failure [11,12].…”
Envenoming syndrome is an uncommon condition associated with significant morbidity and mortality following multiple Hymenoptera stings. We review the case of a 90-year-old male who presented after receiving greater than 100 bee stings and was found to have rhabdomyolysis with concomitant acute kidney injury. Physicians should consider envenoming syndrome in all patients presenting with greater than 50 bee stings, despite hemodynamically stability upon initial presentation.
“…Delayed hypersensitivity is rarely observed. The notion of prior stings has not been reported for the patient, but the number of stings exceeds the threshold of one sting per kilogram that can lead to systemic effect in children [3].…”
Section: Discussionmentioning
confidence: 99%
“…Massive bee stings can be deadly from 20 bites/kg of weight [3] but cases of patients that have survived several hundred stings have been reported [2] [8] [9].…”
Introduction: We are reporting a deadly case of massive bee stings observed in a 7-year-old child in Ouagadougou. Observation: The first symptoms, which appeared two hours after the stings of about 200 bees, motivated a consultation in a nearby dispensary in which the child received intravenous betamethasone before being referred to the University Hospital Center Yalgado Ouédraogo (CHUYO). Seven hours after the accident, a rapid deterioration in the general condition was noted with hemorrhage, respiratory distress, coma, and shock. A grade 3 anaphylaxis was diagnosed. The patient didn't survive despite of the cardiopulmonary resuscitation using adrenaline in intensive care. Conclusion: The massive bee stings have caused a severe biphasic anaphylactic reaction which could not be reversed by the adrenaline administered in the second phase. The development of a protocol would contribute to a better management of the cases.
“…Bee envenomation is a problem in India, China, Latin America, Middle East, North and South Africa [16]. About 200 stings from Apis mellifera could cause envenoming syndrome in children and elderly [17] as multiple stings, not increased venom potency or delivery cause serious reactions [18]. Bee venoms differ in weight, concentrations of phospholipase and melittin [19].…”
Toxicosis is a poisoning caused by venomous animals such as snake, scorpion, honeybee, spider and wasp. Their poisons contain amino acids, peptides, proteins, enzymes and metallic ions that are responsible for neurotoxicity, hemotoxicity and myotoxicity. Because of in vivo therapeutic challenges posed by toxicosis, there is need for ideal therapeutic agents against envenomation caused by venomous animals. Findings have shown that toxicosis could be treated symptomatically. Snake and scorpion antivenins could be used for treatment of poisoning caused by snake, scorpion, honeybee, spider and wasp. The amount of antivenin is dependent on the quantity of venom injected into the affected individuals. Moreso, sympotomatic treatments are also done according to the systems affected. Hospitalization is necessary for assessment of therapeutic success.
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