RPS27a promotes proliferation, regulates cell cycle progression and inhibits apoptosis of leukemia cells

Wang, Houcai; Yu, Jing; Zhang, Lixia; Xiong, Yuanyuan; Chen, Shuying; Xing, Haiyan; Tian, Zheng; Tang, Kejing; Wei, Hui; Rao, Qing; Wang, Min; Wang, Jianxiang

doi:10.1016/j.bbrc.2014.03.086

Cited by 55 publications

(40 citation statements)

References 25 publications

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“…Ubiquitin acts as a chaperone for its fusion partners and hence its presence is critical for proper ribosome biogenesis and thereof mRNA translation [37]. This is in line with the observation where exogenous expression of RPS27A has already been shown to induce cell proliferation whereas inhibition reduced the cell viability, induced cell cycle arrest at S and G2/M phases and increased cell apoptosis in the culture [38]. Whereas, inhibition of UBA52 didn't showed similar effects on cellular health as expression of only ~7% mRNAs was observed to be altered suggesting transcript-specific translation by the UBA52 [39].…”

Section: Functional Analysis Of Microvesicular Proteinssupporting

confidence: 75%

Exploring Packaged Microvesicle Proteome Composition of Chinese Hamster Ovary Secretome

2016

J Bioprocess Biotech

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Section: Functional Analysis Of Microvesicular Proteinssupporting

confidence: 75%

Exploring Packaged Microvesicle Proteome Composition of Chinese Hamster Ovary Secretome

2016

J Bioprocess Biotech

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“…As reported, the Uba80 encodes ubiquitin fused to ribosomal protein S27a, which promotes proliferation, inhibits cell apoptosis, and responses to ribosomal stress [49,50,51]. PPAR-α and PPAR-γ agonist, a stress-induced transcription factor in response to reducing oxidative stress and others, benefit brain ischemia and injury recovery by protecting against neuron apoptosis [52,53].…”

Section: Discussionmentioning

confidence: 99%

Identification of Differentially Expressed Micrornas Associate with Glucose Metabolism in Different Organs of Blunt Snout Bream (Megalobrama amblycephala)

Miao

Lin

Pan

et al. 2017

IJMS

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Blunt snout bream (Megalobrama amblycephala) is a widely favored herbivorous fish species and is a frequentlyused fish model for studying the metabolism physiology. This study aimed to provide a comprehensive illustration of the mechanisms of a high-starch diet (HSD) induced lipid metabolic disorder by identifying microRNAs (miRNAs) controlled pathways in glucose and lipid metabolism in fish using high-throughput sequencing technologies. Small RNA libraries derived from intestines, livers, and brains of HSD and normal-starch diet (NSD) treated M. amblycephala were sequenced and 79, 124 and 77 differentially expressed miRNAs (DEMs) in intestines, livers, and brains of HSD treated fish were identified, respectively. Bioinformatics analyses showed that these DEMs targeted hundreds of predicted genes were enriched into metabolic pathways and biosynthetic processes, including peroxisome proliferator-activated receptor (PPAR), glycolysis/gluconeogenesis, and insulin signaling pathway. These analyses confirmed that miRNAs play crucial roles in glucose and lipid metabolism related to high wheat starch treatment. These results provide information on further investigation of a DEM-related mechanism dysregulated by a high carbohydrate diet.

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“…However, the genes specifically controlling the size of DP and matrix remain elusive. In the present study, the up-regulated genes in the super fine wool group included 5 genes associated with the cell cycle and apoptosis: GSDMA3 [56], HSPA2 [57], RPS27A [58], PDCD6IP [59], DAP [60], CCNA2 [61] and FOS [62]; the down-regulated genes included 7 genes associated with promoting follicle cell proliferation and differentiation: KRT1 [63, 64], KRT7 [65, 66], HSD11B1 [67, 68], S100A8 [41, 69, 70], NT5C3 L [71] and DNAJC12 [72]. These genes may through promoting HF cell apoptosis, inhibiting follicle cell proliferation and differentiation, thereby reduce the WFD.…”

Section: Discussionmentioning

confidence: 99%

Exploring Differentially Expressed Genes and Natural Antisense Transcripts in Sheep (Ovis aries) Skin with Different Wool Fiber Diameters by Digital Gene Expression Profiling

et al. 2015

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Wool fiber diameter (WFD) is the most important economic trait of wool. However, the genes specifically controlling WFD remain elusive. In this study, the expression profiles of skin from two groups of Gansu Alpine merino sheep with different WFD (a super-fine wool group [FD = 18.0 ± 0.5 μm, n= 3] and a fine wool group [FD=23.0±0.5μm, n=3]) were analyzed using next-generation sequencing–based digital gene expression profiling. A total of 40 significant differentially expressed genes (DEGs) were detected, including 9 up-regulated genes and 31 down-regulated genes. Further expression profile analysis of natural antisense transcripts (NATs) showed that more than 30% of the genes presented in sheep skin expression profiles had NATs. A total of 7 NATs with significant differential expression were detected, and all were down-regulated. Among of 40 DEGs, 3 DEGs (AQP8, Bos d2, and SPRR) had significant NATs which were all significantly down-regulated in the super-fine wool group. In total of DEGs and NATs were summarized as 3 main GO categories and 38 subcategories. Among the molecular functions, cellular components and biological processes categories, binding, cell part and metabolic process were the most dominant subcategories, respectively. However, no significant enrichment of GO terms was found (corrected P-value >0.05). The pathways that were significantly enriched with significant DEGs and NATs were mainly the lipoic acid metabolism, bile secretion, salivary secretion and ribosome and phenylalanine metabolism pathways (P < 0.05). The results indicated that expression of NATs and gene transcripts were correlated, suggesting a role in gene regulation. The discovery of these DEGs and NATs could facilitate enhanced selection for super-fine wool sheep through gene-assisted selection or targeted gene manipulation in the future.

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RPS27a promotes proliferation, regulates cell cycle progression and inhibits apoptosis of leukemia cells

Cited by 55 publications

References 25 publications

Exploring Packaged Microvesicle Proteome Composition of Chinese Hamster Ovary Secretome

Exploring Packaged Microvesicle Proteome Composition of Chinese Hamster Ovary Secretome

Identification of Differentially Expressed Micrornas Associate with Glucose Metabolism in Different Organs of Blunt Snout Bream (Megalobrama amblycephala)

Exploring Differentially Expressed Genes and Natural Antisense Transcripts in Sheep (Ovis aries) Skin with Different Wool Fiber Diameters by Digital Gene Expression Profiling

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