Royal Jelly Modulates Oxidative Stress and Apoptosis in Liver and Kidneys of Rats Treated with Cisplatin

Karadeniz, Ali; Şimşek, Nejdet; Karakuş, Emre; Yıldırım, Serap; Kara, Adem; Can, İsmail Özgür; Kisa, Fikrullah; Emre, Habib; Türkeli, Mehmet

doi:10.1155/2011/981793

Cited by 135 publications

(112 citation statements)

References 57 publications

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“…These data suggest that although the functions of RJ on the antioxidant activities in the serum, liver and kidney were different, overall, the antioxidant activities increased following RJ supplementation in 4T1-bearing mice. These results are in agreement with the literature on the antioxidant properties of RJ (40,41). It is possible that administration of RJ enhances antioxidant activity, since RJ contains a mixture of peptides, flavonoids and cinnamic acid derivatives (42).…”

Section: Discussionsupporting

confidence: 92%

The effect of royal jelly on the growth of breast cancer in mice

et al. 2017

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Abstract. Due to various pharmacological properties, including antioxidative, anti-inflammatory and antibiotic properties, royal jelly (RJ) has been widely consumed in daily diets in numerous countries. In the present study, the effect of RJ on 4T1-bearing mice was investigated. The study was performed by feeding 4T1-bearing mice with RJ using either the prophylactic-therapeutic (PTRJ) or therapeutic (TRJ) method. The experimental results for the PTRJ group demonstrated that the weight of tumor was significantly reduced (RJ 0.5 and 1.5 g/kg); and in the serum, the levels of interleukin (IL)-2 (RJ 0.5 and 1.5 g/kg), interferon (IFN)-α, superoxide dismutase (SOD) and total antioxidant capacity (T-AOC) were significantly elevated, but the concentrations of IL-4 (RJ 0.5 and 1.5 g/kg) and IL-10 (RJ 1.0 g/kg) were significantly decreased. In addition, the activities of T-AOC and glutathione reductase (GR) were significantly improved in the liver, whereas in the kidney, the activities of T-AOC and GR were significantly increased only under the dose of 0.5 g/kg. For the TRJ group, the antitumor effect of RJ was not significant; the change in IL-2, IFN-α, SOD and T-AOC levels in the serum, and the change in T-AOC and GR in liver were similar to those observed in the PTRJ groups. RJ treatment was demonstrated to reduce the development of breast tumor in mice, and simultaneously improve the antioxidant capacity of the serum, liver and kidney, particularly using the prophylactic-therapeutic method. These results corroborated the efficacy of RJ supplementation in diets. The results of the present study suggest that the antioxidant and immunomodulatory activities of RJ serve an important role on antitumor growth.

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Section: Discussionsupporting

confidence: 92%

The effect of royal jelly on the growth of breast cancer in mice

et al. 2017

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“…(24). Practically the same effects were found after the treatment of the Pancreatic Cancer Cell tumour cells PaCa-44 with 10-HDA, where the induction of the apoptosis was found (25).…”

Section: Gsh Determination and Measurement Of Lipid Peroxidationsupporting

confidence: 53%

The influence of royal jelly and human interferon-alpha (HuIFN-αN3) on proliferation, glutathione level and lipid peroxidation in human colorectal adenocarcinoma cells in vitro / Vpliv matičnega mlečka in humanega interferona-alfa (HuIFN-αN3) na proliferacijo, nivo glutationa in na preoksidacijo lipidov v humanih kolorektalnih adenokarcinomskih celicah in vitro

Filipič

Gradišnik

Rihar

et al. 2015

Archives of Industrial Hygiene and Toxicology

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Among royal jelly's (RJ) various biological activities, its possible antitumour activity deserves particular attention. The purpose of this study was to investigate the influence of RJ, its bioactive component 10-hydroxy-2-decenoic acid (10-HDA), and human interferon-alpha (HuIFN-αN3) on the proliferation of human colorectal adenocarcinoma cells (CaCo-2), and ascertain their effect on intracellular glutathione (GSH) level and lipid peroxidation. We studied the antiproliferative (AP) activity of RJ [(0.1 g/10 mL phosphate buffer saline (PBS)], HuIFN-αN3 (1000 I.U. mL , and their different combinations, in the ratio 1:1, 1:2, and 2:1 on CaCo-2 cells. The GSH level was measured by glutathione assay. The lipid peroxidation was measured by malondialdehyde (MDA) assay. Single RJ had a low AP activity: 2.0 (0.5 mg mL -1 ). HuIFN-αN3 had an AP activity of 2.5 (208.33 I.U. mL -1 ), while 10-HDA had an AP activity of 1.5 (37.5 μmol mL). The highest AP activity of 3.8 was obtained when RJ and HuIFN-αN3 were applied at the ratio 2:1. In that combination the level of GSH was 24.9±2.4 nmol g -3 of proteins (vs. 70.2±3.2 nmol g -3 in the control) and the level of MDA was 72.3±3.1 nmol g -3 (vs. 23.6±9.1 nmol g -3 in the control). It is generally assumed that 10-HDA, an important constituent of RJ, together with HuIFN-αN3, is responsible for the inhibition of CaCo-2 cells proliferation in vitro. In our study, however, RJ and HuIFN-αN3 applied at 2:1 decreased the level of GSH the most and significantly increased lipid peroxidation via MDA in CaCo-2 cells. Future studies should show whether these GSH-and MDA-related activities of RJ, HuIFN-αN3, 10-HDA, and their combinations may decrease the tumorigenicity index and tumorigenic potential of various tumour cells in vitro. KEY WORDS: antiproliferative activity; antitumour activity; CaCo-2 cells; 10-hydroxy-2-decenoic acid; malondialdehydeRoyal jelly (RJ) is a milky material secreted by the hypopharyngeal and mandibular glands of young worker bees between the sixth and twelfth day of their life. It is food exclusively for the queen honey bee (Apis mellifera) larva, which leads to the development of a sexually mature queen bee (1, 2). Chemically, RJ comprises water (50-60 %), different proteins (18.0 %), carbohydrates (15.0 %), lipids (3-6 %), mineral salts (1.5 %), and vitamins, together with a large number of bioactive substances, such as 10-hydroxy-2-decenoic (10-HDA) acid (3). RJ exhibits various immunomodulatory and antiproliferative properties, as well as possible antitumour activity. It also contains different antibacterial proteins like 350-kDa protein stimulating the proliferation of human monocytes (4-6). In addition, the RJ Protein 30 fraction exhibits a clear cytotoxic effect on HeLa cells by decreasing the initial cell population by 50 % at the end of treatment (7).Impact of royal jelly and HuIFN-αN3 on proliferation, glutathione, and lipid peroxidation in human colorectal adenocarcinoma cells in vitro Arh Hig Rada Toksikol 2015;66:269-274

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“…Cisplatin is a potent chemotherapeutic drug that is widely used to treat patients with multiple solid tumours, including ovarian, testicular and head and neck cancers [1,2]. In spite of its considerable clinical benefit, cisplatin therapy is accompanied with undesirable side effects, which has been an increasing concern to clinical doctors.…”

Section: Introductionmentioning

confidence: 99%

Baicalein and its underlying mechanism as a protector against liver injury induced by cisplatin in mice

Niu

Wan

Bian

et al. 2016

Biotechnology & Biotechnological Equipment

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Cisplatin is widely used for the treatment of a variety of cancers but with a high incidence of hepatotoxicity. Baicalein is originally isolated from the root of Scutellaria baicalensis Georgi with broad bioactivities. The present study aims to investigate the protective effect of baicalein against cisplatin-induced acute liver injury and the underlying mechanism of this protective effect. Administration of cisplatin (40 mg/kg) for 24 h increased the serum alanine and aspartate aminotransferases and alkaline phosphatase levels, while baicalein could reverse all those changes induced by cisplatin. Liver histological analysis further evidenced the protection of baicalein against cisplatin-induced liver injury. Baicalein counteracted the increased liver malondialdehyde (amount induced by cisplatin, while baicalein could further increase the cisplatin-induced elevation of the amount of reduced glutathione in the liver. Further results showed that baicalein reversed the cisplatin-induced decrease in the activities of superoxide dismutase, catalase, glutathione peroxidase, glutathione-S transferase and glutathione reductase. On the other hand, baicalein alleviated the increase in the serum levels of tumour necrosis factor alpha and interleukin 6 induced by cisplatin. Taken together, our results demonstrate that baicalein can inhibit cisplatininduced hepatic oxidative stress and inflammation, which contributes greatly to the amelioration of cisplatin-induced liver injury.

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Royal Jelly Modulates Oxidative Stress and Apoptosis in Liver and Kidneys of Rats Treated with Cisplatin

Cited by 135 publications

References 57 publications

The effect of royal jelly on the growth of breast cancer in mice

The effect of royal jelly on the growth of breast cancer in mice

Baicalein and its underlying mechanism as a protector against liver injury induced by cisplatin in mice

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