Routine mechanical ventricular assist following the Norwood procedure—improved neurologic outcome and excellent hospital survival

Ungerleider, Ross M.; Shen, Irving; Yeh, Thomas; Schultz, Jess M.; Butler, Robert W.; Silberbach, Michael; Giacomuzzi, Carmen; Heller, Eileen; Studenberg, Leanne; Mejak, Brian; You, Jamie; Farrel, Debbie; McClure, Scott R.; Austin, Erle H.

doi:10.1016/s0003-4975(03)01365-1

Cited by 125 publications

(68 citation statements)

References 22 publications

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“…Others have suggested increased incidence of arrhythmias and increased feeding intolerance among children with genetic syndromes [11,16,18]. In a recent survey of patient selection for neonatal ECMO, only 3 % of the respondents considered Down syndrome to be an absolute contraindication to ECMO, with 68 % of the respondents stating that they would usually or always offer ECMO to neonates with Down syndrome who otherwise meet ECMO criteria [22].…”

Section: Discussionmentioning

confidence: 99%

Extracorporeal Membrane Oxygenation in Children with Heart Disease and Down Syndrome: A Multicenter Analysis

et al. 2014

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The data on the outcomes of children with heart disease and Down syndrome receiving extracorporeal membrane oxygenation (ECMO) for cardiac or respiratory failure are limited. This study aimed to evaluate morbidity and mortality associated with ECMO in children with Down syndrome and heart disease. Children younger than 18 years undergoing heart surgery and ECMO reported in the Extracorporeal Life Support Organization (ELSO) registry (1998-2011) were included in the study. The registry was queried for the following five heart defects: common atrioventricular (AV) canal, tetralogy of Fallot, truncus arteriosus, transposition of great vessels, and interrupted aortic arch. Data collection included patient characteristics, ECMO characteristics, and outcomes. The outcomes evaluated included mortality, ECMO duration, and length of hospital stay for patients with Down syndrome and those with no Down syndrome. The study enrolled 2,815 patients qualified for inclusion. Of these patients, 121 had Down syndrome, whereas 2,694 had no genetic syndrome and were included in the control group. The median age of the patients was 45 days (interquartile range [IQR] 9-192 days), and the median weight was 3.8 kg (IQR 3.0-6.1 kg). The most common cardiac defects in Down syndrome group were common AV canal (63 %) and tetralogy of Fallot (40 %). The Down syndrome group included older patients with greater body weight than the control group. The mortality rate was lower in the Down syndrome group than in the control group (44 vs. 56 %; p = 0.01). The duration of ECMO and length of hospital stay were similar in the two groups. The findings showed that ECMO can be used for children with heart disease and Down syndrome with good results. The outcomes were comparable between the children with Down syndrome and the children without Down syndrome.

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Section: Discussionmentioning

confidence: 99%

Extracorporeal Membrane Oxygenation in Children with Heart Disease and Down Syndrome: A Multicenter Analysis

et al. 2014

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“…In some centres this approach is becoming much more routine, with very encouraging outcomes. 34 Therefore, although carrying a significant risk, ECLS can, if initiated promptly, improve the outcome in infants with impaired cardiopulmonary function after stage 1 palliation. 35 …”

Section: Extracorporeal Life Supportmentioning

confidence: 99%

The intensive care of infants with hypoplastic left heart syndrome

Theilen

Shekerdemian²

2005

Archives of Disease in Childhood - Fetal and Neonatal Edition

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“…These factors encouraged some groups to use the ECMO routinely after complex neonatal surgeries such as the first stage of Norwood 23 .…”

Section: Discussionmentioning

confidence: 99%

Emprego do suporte cardiopulmonar com bomba centrífuga e oxigenador de membrana em cirurgia cardiovascular pediátrica

Atik¹,

Castro²,

Succi³

et al. 2008

Arq. Bras. Cardiol.

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Routine mechanical ventricular assist following the Norwood procedure—improved neurologic outcome and excellent hospital survival

Cited by 125 publications

References 22 publications

Extracorporeal Membrane Oxygenation in Children with Heart Disease and Down Syndrome: A Multicenter Analysis

Extracorporeal Membrane Oxygenation in Children with Heart Disease and Down Syndrome: A Multicenter Analysis

The intensive care of infants with hypoplastic left heart syndrome

Emprego do suporte cardiopulmonar com bomba centrífuga e oxigenador de membrana em cirurgia cardiovascular pediátrica

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