Routine analysis of cirrhotic ascites for evidence of infection – not worth the effort?

Varghese, Thomas

doi:10.1007/s12664-011-0136-2

Cited by 9 publications

(8 citation statements)

References 18 publications

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“…Coagulase negative staphylococcus and Acinetobacter spp. were the highest bacterial isolates in our findings that are in agreement with studies conducted in Iran, Korea and Brazil [1,[17][18][19]. The detection of Coagulase negative Staphylococci & Acinetobacter spp.…”

Section: Discussionsupporting

confidence: 92%

Bacterial Profile and their Antimicrobial Resistance Patterns from Body Fluids at Tikur Anbesa Specialized Hopital, Addis Ababa, Ethiopia

Teklehymanot¹,

Legese²,

Desta³

2017

Biol Med

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Background: Infections caused by multidrug resistant (MDR) bacteria remain a public health threat for patients and health care workers. There are scarcity of data on bacterial profiles and their drug susceptibility patterns from body fluids in Ethiopia. Hence, this study aimed at assessing bacterial profiles and their antimicrobial susceptibility patterns (AST) from body fluids at Tikur Anbessa Specialized Hospital (TASH), Addis Ababa, Ethiopia.

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Section: Discussionsupporting

confidence: 92%

Bacterial Profile and their Antimicrobial Resistance Patterns from Body Fluids at Tikur Anbesa Specialized Hopital, Addis Ababa, Ethiopia

Teklehymanot¹,

Legese²,

Desta³

2017

Biol Med

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“…Bacterial infections are frequently observed in patients with cirrhosis, among which spontaneous bacterial peritonitis (SBP) is probably the most serious complication in advanced cirrhosis of the liver [1]. Patients with SBP may present with fever, abdominal pain, deterioration of renal function, hypotension, or development of encephalopathy [2].…”

Section: Introductionmentioning

confidence: 99%

Macrophage Inflammatory Protein-1 Beta (MIP-1<i>β</i>) and Platelet Indices as Predictors of Spontaneous Bacterial Peritonitis<br> —MIP, MPV and PDW in SBP

Khorshed¹,

Ibraheem²,

Awad³

2015

OJGas

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Background/Aims: The objective of this study is to measure macrophage inflammatory protein one beta (MIP-1β), mean platelet volume (MPV) and platelet distribution width (PDW) to evaluate their usefulness in the diagnosis of spontaneous bacterial peritonitis (SBP) in cirrhotic patients. Materials and Methods: This study comprised 41 cirrhotic patients with ascites. MPV, PDW and MIP-1β were measured in serum and ascitic fluid. Results: A significant increase MPV, PDW, C-reactive Protein (CRP) and white blood cell was observed in SBP group compared to non SBP (P ≤ 0.001, P = 0 < 0.004, P = 0.001, P = 0.001 respectively). In addition, MIP-1β was significantly increased in ascitic fluid in patients with SBP versus non SBP (P ≤ 0.001). At cutoff value of 8.3 fl MPV had 85.7% sensitivity and 75% specificity (AUC = 0.876) for diagnosis of SBP. At cutoff value of 15.4 PDW had 90.4% sensitivity and 55% specificity (AUC = 0.762). At cutoff value of 121.9 pg/ml MIP-1β in ascitic fluid had 76.1% sensitivity and 100% specificity (AUC = 0.881) for detecting SBP. Conclusion: MIP-1β and platelet indices are useful marker in the diagnosis of SBP in cirrhotic patients. Combined measurement of MIP-1β in serum and ascitic fluid had 100% sensitivity and specificity for diagnosis of SBP.

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“…Keywords: ascitic fluid infection, FISH, spontaneous bacterial peritonitis Introduction Bacterial infections are frequently observed in patients with cirrhosis, among which spontaneous bacterial peritonitis (SBP) is probably the most serious complication in advanced cirrhosis of the liver [1]. Patients with SBP usually show symptoms such as fever, abdominal pain (not a symptom), deterioration of renal function, hypotension, or development of encephalopathy [2].…”

Section: Resultsmentioning

confidence: 99%

Fluorescence in-situ hybridization as a novel technique for rapid and sensitive detection of ascitic fluid infection

Hendy¹,

Allam²,

Mottaleb³

et al. 2012

Egyptian Liver Journal

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Routine analysis of cirrhotic ascites for evidence of infection – not worth the effort?

Cited by 9 publications

References 18 publications

Bacterial Profile and their Antimicrobial Resistance Patterns from Body Fluids at Tikur Anbesa Specialized Hopital, Addis Ababa, Ethiopia

Bacterial Profile and their Antimicrobial Resistance Patterns from Body Fluids at Tikur Anbesa Specialized Hopital, Addis Ababa, Ethiopia

Macrophage Inflammatory Protein-1 Beta (MIP-1<i>β</i>) and Platelet Indices as Predictors of Spontaneous Bacterial Peritonitis<br> —MIP, MPV and PDW in SBP

Fluorescence in-situ hybridization as a novel technique for rapid and sensitive detection of ascitic fluid infection

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Routine analysis of cirrhotic ascites for evidence of infection – not worth the effort?

Cited by 9 publications

References 18 publications

Bacterial Profile and their Antimicrobial Resistance Patterns from Body Fluids at Tikur Anbesa Specialized Hopital, Addis Ababa, Ethiopia

Bacterial Profile and their Antimicrobial Resistance Patterns from Body Fluids at Tikur Anbesa Specialized Hopital, Addis Ababa, Ethiopia

Macrophage Inflammatory Protein-1 Beta (MIP-1&lt;i&gt;β&lt;/i&gt;) and Platelet Indices as Predictors of Spontaneous Bacterial Peritonitis&lt;br&gt; —MIP, MPV and PDW in SBP

Fluorescence in-situ hybridization as a novel technique for rapid and sensitive detection of ascitic fluid infection

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Macrophage Inflammatory Protein-1 Beta (MIP-1<i>β</i>) and Platelet Indices as Predictors of Spontaneous Bacterial Peritonitis<br> —MIP, MPV and PDW in SBP