Roundup-induced biochemical and histopathological changes in the liver and kidney of rats: the ameliorative effects of Linum usitatissimum oil

Abstract

The present study was undertaken to evaluate the protective effects of Linum usitatissimum oil (LuO) against sub-chronic Roundup (RDP)-induced toxicity and oxidative stress in rats. Rats were divided into four groups: control group (no treatment), RDP group (Roundup at 269.9 mg/kg b.w.), LuO group (0.5 g/kg b.w. of LuO) and RDP+LuO group (RDP and LuO simultaneously). LuO decreased the ferric reducing antioxidant power (FRAP) (IC50=10.36 μg/ml) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) (IC50=22.85 mg/ml) in the tested tissues. The 30-day exposure of rats to RDP caused an increase in serum hepatic and renal markers: AST, ALT, ALP, LDH, γGT, bilirubin, urea, and creatinine. In addition, SOD, CAT and GST activities decreased by 43%, 61%, and 61%, respectively, while GPx activity, MDA and PCOs levels increased by 80%, 46%, 25%, respectively. LuO treatment alleviated hepatotoxicity in RDP-treated rats, showing improved levels of oxidative stress biomarkers and plasma biochemical parameters. The histological examination of the liver and kidney confirmed the changes in Roundup-treated rats and demonstrated the protective role of LuO.

A glyphosate-based herbicide disrupted hematopoiesis and induced organ toxicities, ameliorated by vitamin B12 in a mouse model

“…The hypertriglyceridemia and high HDL may be attributed to increase in the lipid rate of peroxidation and free radical release. These findings corroborate similar studies by Djaber et al, 2020 , El-Shenawy, 2009 . Again, the findings from the current study showed that cyanocobalamin treatment before or after GBH exposure was effective in stabilizing the cholesterol levels in the blood.…”

“…Glyphosate-based herbicides (GBHs) are among the economically important agrochemicals widely used. Glyphosate, chemically referred to as N-phosphonomethyl glycine is the active ingredient in GBHs, which include formulations such as Roundup ( Djaber et al, 2020 , Panzacchi et al, 2018 ).…”

Inventory of Medicinal Plants Used Traditionally to Manage Kidney Diseases in North-Eastern Morocco: Ethnobotanical Fieldwork and Pharmacological Evidence

“…Ameliorative effects on roundup-induced biochemical and histopathological changes in the liver and kidney of rats 0.5 g/kg of body weight [109] Morus alba L.…”

Effects of medicine food Fructus Gardeniae on liver and kidney functions after oral administration to rats for 12 weeks

“…According to our results obtained after treatment of rats for 3 months, oral administration of decocted FG, geniposide, and genipin detrimentally effected the body weight of rats and caused the liver and kidneys to swell over time. AST, ALT, and ALP are typical indicators of liver function, while CRE and BUN are indicative of kidney function (Djaber et al., 2020; Kamel et al., 2020). When renal function is impaired, serum CRE will increase obviously (Wang et al., 2010), and BUN will be discharged through glomerular filtration (Suzuki et al., 2019).…”