Round-cell tumours of bone

Lumb, George; Mackenzie, D. H.

doi:10.1002/bjs.18004318008

Cited by 13 publications

(2 citation statements)

References 19 publications

(3 reference statements)

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“…(2) From the radiologist's standpoint, Ewing's sarcoma would be a reasonable diagnosis, but a 17 533 five years' survival is unusual. From the pathologist's standpoint, Ewing's sarcoma is characteristically composed of fairly uniform round cells, not pleomorphic as in this case, and reticulin production is not a feature (Dahlin et al 1961, McCormack et al 1952, Lumb & Mackenzie 1956.…”

Section: Hande Xj95mentioning

confidence: 72%

Tumour of Bone, Testis and Breast: Reticulum Cell Sarcoma

Sh¹

1969

Proceedings of the Royal Society of Medicine

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Section: Hande Xj95mentioning

confidence: 72%

Tumour of Bone, Testis and Breast: Reticulum Cell Sarcoma

Sh¹

1969

Proceedings of the Royal Society of Medicine

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“…Gouyou (1946), in the course of his study of reticulin in seminomas, found that the reticulin patter was of value in distinguishing necrotic tumours which contained reticulin from gummata. Valls, Musculo and Schajowicz (1952) claimed that the amount of reticulin in reticulum cell sarcomas of bone was greater than that observed in Ewing's tumour and this has been the writer's experience (Lumb and Mackenzie, 1956). …”

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Reticulin Patterns in the Diagnosis of Carcinomas and Sarcomas

Mackenzie¹

1958

Br J Cancer

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Extraskeletal neoplasm resembling Ewing's sarcoma

Angervall

Enzinger

1975

Cancer

431

213

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This article reviews the pathologic features and the behavior of 39 small, round, or oval cell sarcomas occurring in the soft tissues and considered histologically indistinguishable from Ewing's sarcoma of bone. The tumors affected chiefly young adults (median age 20 years) and most commonly involved the soft tissues of the lower extremity and the paravertebral region. Microscopically, they consisted of solidly packed small, round, or ovoid cells of great uniformity, arranged in sheets or lobules separated by strands of fibrous connective tissue. The nucleus of the tumor cells contained finely divided chromatin, a distinct nuclear membrane, and frequently a minute nucleolus. The scanty ill-defined cytoplasm contained varying amounts of glycogen. Sometimes the histologic picture was dominated by a "peritheliomatous" pattern, or by large areas of necrosis or hemorrhage. Followup data ranging from 1 month to 14 years were available in 35 of the 39 cases (93%). Of these, 13 were alive and 22 had died. In the majority of the fatal cases, the clinical course was rapid; metastatic lesions developed within a few months after the primary tumor was excised. The lungs and the skeleton were the two most common sites of metastasis. Cure may be achieved by wide local excision of the tumor at an early stage of the disease, combined with radiation therapy and chemotherapy.

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Round-cell tumours of bone

Cited by 13 publications

References 19 publications

Tumour of Bone, Testis and Breast: Reticulum Cell Sarcoma

Tumour of Bone, Testis and Breast: Reticulum Cell Sarcoma

Reticulin Patterns in the Diagnosis of Carcinomas and Sarcomas

Extraskeletal neoplasm resembling Ewing's sarcoma

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